Xiaodong Liu – författare

This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presentsa number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.

This book gathers papers presented at the 9th International Conference on Computer Engineering and Networks (CENet2019), held in Changsha, China, on October 18–20, 2019. It examines innovations in the fields of computer engineering and networking and explores important, state-of-the-art developments in areas such as Information Security, Information Hiding and Cryptography, Cyber Security, and Intelligent Computing and Applications. The book also covers emerging topics in computer engineering and networking, along with their applications, discusses how to improve productivity by using the latest advanced technologies, and examines innovation in the fields of computer engineering and networking, particularly in intelligent computing and security.

This book addresses a controversial issue regarding SL-TL transfer in the translation process, namely the question as to the dominant route in English-Chinese and Chinese-English professional consecutive interpretations, respectively: the form-based processing route or meaning-based processing route. It presents a corpus-assisted product study, in which the interpreting processing patterns of culture-specific items (CSIs) are analyzed. The study reveals that the dominant route in English vs. Chinese consecutive interpreting varies under different circumstances. Four factors are proposed to account for such differences: linguistic variables (e.g., grammatical complexity of the unit), type of CSI, language direction, and extra-linguistic variables (e.g., multilateral or bilateral settings). In summary, the book systematically introduces a corpus-assisted approach to translation process research, which will benefit all readers who are interested in translation process research but cannot employ neuroscientific measures.