Yan Cui – författare

Stimulation of the immune system’s ability to control and destroy tumors cont- ues to be the goal of cancer immune therapy; but the scope has rapidly expanded; approaches are constantly updated; new molecules are continually introduced; and immune mechanisms are becoming better understood. This book has no intention of covering every aspect of immune therapy but rather focuses on the novelty of cancer immune therapy in an attempt to give readers an opportunity to absorb the new aspects of immune therapy from a single source. In this regard, three areas were selected: cytokine immune therapy, cell-based immune therapy, and targeted immune therapy. In each of these three sections, only the novel aspects of immune therapy were described instead of attempting to cover any historical achievement. In the first section, Cytokine Immune Therapy, the IL12 family, IL18, IL21, IL24, IL28, and IL29 were emphasized in regard to the an- tumor function and application in treating tumors. Most of these selected cyt- ines were discovered in last 10 years. In the second section, Cell-based Immune Therapy, the focus was engineering potent immune regulatory or effector cells such as dendritic cells, T cells, and stem cells. Cell engineering design is primarily based on the increased understanding of the interaction of tumor antigen-presenting cells, antigen- specific effector cells, and the tumor microenvironment.

Stimulation of the immune system’s ability to control and destroy tumors cont- ues to be the goal of cancer immune therapy; but the scope has rapidly expanded; approaches are constantly updated; new molecules are continually introduced; and immune mechanisms are becoming better understood. This book has no intention of covering every aspect of immune therapy but rather focuses on the novelty of cancer immune therapy in an attempt to give readers an opportunity to absorb the new aspects of immune therapy from a single source. In this regard, three areas were selected: cytokine immune therapy, cell-based immune therapy, and targeted immune therapy. In each of these three sections, only the novel aspects of immune therapy were described instead of attempting to cover any historical achievement. In the first section, Cytokine Immune Therapy, the IL12 family, IL18, IL21, IL24, IL28, and IL29 were emphasized in regard to the an- tumor function and application in treating tumors. Most of these selected cyt- ines were discovered in last 10 years. In the second section, Cell-based Immune Therapy, the focus was engineering potent immune regulatory or effector cells such as dendritic cells, T cells, and stem cells. Cell engineering design is primarily based on the increased understanding of the interaction of tumor antigen-presenting cells, antigen- specific effector cells, and the tumor microenvironment.

Stimulation of the immune system’s ability to control and destroy tumors cont- ues to be the goal of cancer immune therapy; but the scope has rapidly expanded; approaches are constantly updated; new molecules are continually introduced; and immune mechanisms are becoming better understood. This book has no intention of covering every aspect of immune therapy but rather focuses on the novelty of cancer immune therapy in an attempt to give readers an opportunity to absorb the new aspects of immune therapy from a single source. In this regard, three areas were selected: cytokine immune therapy, cell-based immune therapy, and targeted immune therapy. In each of these three sections, only the novel aspects of immune therapy were described instead of attempting to cover any historical achievement. In the first section, Cytokine Immune Therapy, the IL12 family, IL18, IL21, IL24, IL28, and IL29 were emphasized in regard to the an- tumor function and application in treating tumors. Most of these selected cyt- ines were discovered in last 10 years. In the second section, Cell-based Immune Therapy, the focus was engineering potent immune regulatory or effector cells such as dendritic cells, T cells, and stem cells. Cell engineering design is primarily based on the increased understanding of the interaction of tumor antigen-presenting cells, antigen- specific effector cells, and the tumor microenvironment.

Design low-maintenance systems using pre-built cloud services! Bring down costs, automate time-consuming ops tasks, and scale on demand.In Serverless Architectures on AWS, Second Edition you will learn:     First steps with serverless computing     The principles of serverless design     Important patterns and architectures     How successfully companies have implemented serverless     Real-world architectures and their tradeoffs Serverless Architectures on AWS, Second Edition teaches you how to design serverless systems. You’ll discover the principles behind serverless architectures, and explore real-world case studies where companies used serverless architectures for their products. You won’t just master the technical essentials—the book contains extensive coverage of balancing tradeoffs and making essential technical decisions. This new edition has been fully updated with new chapters covering current best practice, example architectures, and full coverage of the latest changes to AWS. About the technology Maintaining server hardware and software can cost a lot of time and money. Unlike traditional data center infrastructure, serverless architectures offload core tasks like data storage and hardware management to pre-built cloud services. Better yet, you can combine your own custom AWS Lambda functions with other serverless services to create features that automatically start and scale on demand, reduce hosting cost, and simplify maintenance. About the book In Serverless Architectures with AWS, Second Edition you’ll learn how to design serverless systems using Lambda and other services on the AWS platform. You’ll explore event-driven computing and discover how others have used serverless designs successfully. This new edition offers real-world use cases and practical insights from several large-scale serverless systems. Chapters on innovative serverless design patterns and architectures will help you become a complete cloud professional. What's inside     First steps with serverless computing     The principles of serverless design     Important patterns and architectures     Real-world architectures and their tradeoffs About the reader For server-side and full-stack software developers. About the author Peter Sbarski is VP of Education and Research at A Cloud Guru. Yan Cui is an independent AWS consultant and educator. Ajay Nair is one of the founding members of the AWS Lambda team. Table of Contents PART 1 FIRST STEPS 1 Going serverless 2 First steps to serverless 3 Architectures and patterns PART 2 USE CASES 4 Yubl: Architecture highlights, lessons learned 5 A Cloud Guru: Architecture highlights, lessons learned 6 Yle: Architecture highlights, lessons learned PART 3 PRACTICUM 7 Building a scheduling service for ad hoc tasks 8 Architecting serverless parallel computing 9 Code Developer University PART 4 THE FUTURE 10 Blackbelt Lambda 11 Emerging practices

This book covers the broad aspects of disaster legislation, governance, and their implementation. The book also includes in-depth reviews and new data, based on case studies across the globe, involving multidisciplinary research. In addition, the book suggests specific policies and action measures to enhance the implementation of disaster legislation for the resilience of people and local governments.Disaster law is the core to disaster risk management. The legal framework not only provides the government an instrument to take actions before, during, and after a disaster, but it also helps in recovery process. The legislative measures provide certain levels of guidance to different stakeholders such as national governments, local governments, civil societies, and more importantly citizens. The legal provision gives people and communities certain obligations as well as responsibilities to act during or before disasters. Over the last several years, there has been new disaster laws formulated in many countries, and revisions have been made to adjust the existing disaster laws to be more effective. Although it is important to have governance provision of disaster law, its implementation is essential.