Yi Yang - Böcker

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A concise introduction to the study of medication utilization and safety in large populations of people

"I found this book useful and clear, and appropriate for beginners in the world of research and, specifically, pharmacoepidemiology. Students could easily learn from this book if used in a classroom setting, where the professor could use the discussion points and questions at the end of each chapter to evaluate student learning. While it reads like a textbook, it is far from boring or dry. 3 Stars."--Doody's Review Service

Understanding Pharmacoepidemiology is a clear, engagingly written roadmap to mastering the important concepts and methods of pharmacoepidemiology. It explains what pharmacoepidemiology is, how pharmacoepidemiology studies are conducted, and how to interpret findings. You will learn the importance of pharmacoepidemiology, basic terminology used in research, and the data sources, study designs, and statistical analyses employed in pharmacoepidemiology research. Upon completing Understanding Pharmacoepidemiology you will have a better understanding of how to evaluate the associations between medication utilization and outcomes.

Each chapter includes these valuable learning aids:

A list of learning objectives Case studies or examplesDiscussion questionsTables and FiguresYou will also find a glossary of important words and terms.

The content you need to understand the concepts and methods of pharmacoepidemiology:Introduction to Pharmacoepidemiology: Principles of Epidemiology Applied to the Study of Medication Use, Study Designs in Pharmacoepidemiology: Using Secondary Data in Pharmacoepidemiology; Biostatistics and Pharmacoepidemiology: Other Methodological Issues; Evaluation of Pharmacoepidemiology Literature; Medication Utilization Patterns; Medication Safety and Pharmacovigilance; and FDA Perspectives on Post-market Drug Safety.

Side Reactions in Peptide Synthesis, based on the author's academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis.

This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development.

While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay.

Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction.

Provides a systematic examination on how to troubleshoot and minimize the most frequent side reactions in peptide synthesis Gives chemists the background information and the practical tools they need to successfully troubleshoot and improve results Includes optimization-oriented analysis of side reactions in peptide synthesis for improved industrial process development in peptidyl API (active pharmaceutical ingredient) production Answers the growing, global need for improved, replicable processes to avoid impurities and maintain the integrity of the end product. Presents a thorough discussion of critical factors in peptide synthesis which are often neglected or underestimated by chemists Covers solid phase and solution phase methodologies, and provides abundant references for further exploration

Modelling and Precision Control of Systems with Hysteresis covers the piezoelectric and other smart materials that are increasingly employed as actuators in precision engineering, from scanning probe microscopes (SPMs) in life science and nano-manufacturing, to precision active optics in astronomy, including space laser communication, space imaging cameras, and the micro-electro-mechanical systems (MEMS). As smart materials are known for having hysteretic dynamics, it is necessary to overcome issues with a broadband range of frequencies.

This book offers both the mathematical tools for modeling the systems and applications, including complete case studies and source code for the experiments to help both academics and researchers in the industry to achieve precision in the control of Smart Actuator systems.

Provides a comprehensive identification of typical complex hysteresis Presents control algorithm design for systems with hysteresis Contain numerous real life examples and two complete case studies Source code to examples are provided

IEC 61850-Based Smart Substations: Principles, Testing, Operation and Maintenance systematically presents principles, testing approaches, and the operation and maintenance technologies of such substations from the perspective of real-world application. The book consists of chapters that cover a review of IEC 61850 based smart substations, substation configuration technology, principles and testing technologies for the smart substation, process bus, substation level, time setting and synchronization, and cybersecurity. It gives detailed information on testing processes and approaches, operation and maintenance technologies, and insights gained through practical experience.

As IEC 61850 based smart substations have played a significant role in smart grids, realizing information sharing and device interoperation, this book provides a timely resource on the topics at hand.

Contributes to the overall understanding of standard IEC 61850, analyzing principles and features Introduces best practices derived from hundreds of smart substation engineering applications Summarizes current research and insights gained from practical experience in the testing, operation and maintenance of smart substation projects in China Gives systematic and detailed information on testing technology Introduces novel technologies for next-generation substations

This accessible and practical shortform book details the properties and advantages of high-performance pre-engineered steel-concrete composite beams (HPCBs) for improving the sustainability of construction techniques. It also explains the analysis methods for testing HPCB systems.The authors describe a new HPCB system that has been developed to reduce the input of raw materials and embodied CO2 commonly associated with heavily loaded and long-spanned industrial buildings (which predominately comprise reinforced concrete) and improve the sustainability of the construction process. They provide several resources throughout to facilitate adoption by professionals.Design equations derived from Eurocode 4 approach for ultimate limit state and serviceability limit state and worked examples are included throughout. The authors discuss the feasibility for both materials and the full-scale beams and CO2 reduction methods, including use of recycled concrete aggregate, ground granulated blast-furnace and silica fume to replace natural coarseaggregates and Ordinary Portland Cement. Guidance for testing HPCBs—including setup, test procedure and data collection and interpretation—is also given. The authors also elaborate on recommendations for finite element analysis for HPCBs. Design examples are appended to illustrate typical current practice using a 12 × 12 m grid floor with live load of 15 kPa. Various considerations for different parameters such as fire resistance are discussed. Finally, the authors present a case study of a recently completed industrial building in Singapore to quantify the benefits of using HPCBs over reinforced concrete and conventional composite construction.Structural engineering professionals, whose work relates to long-span and heavy-loading industrial or commercial buildings, will benefit from the detailed guidance and focus on practical applications provided throughout this book. Post-graduate students of advanced steel and composite structures will also benefit from these descriptions.

This accessible and practical shortform book details the properties and advantages of high-performance pre-engineered steel-concrete composite beams (HPCBs) for improving the sustainability of construction techniques. It also explains the analysis methods for testing HPCB systems.The authors describe a new HPCB system that has been developed to reduce the input of raw materials and embodied CO2 commonly associated with heavily loaded and long-spanned industrial buildings (which predominately comprise reinforced concrete) and improve the sustainability of the construction process. They provide several resources throughout to facilitate adoption by professionals.Design equations derived from Eurocode 4 approach for ultimate limit state and serviceability limit state and worked examples are included throughout. The authors discuss the feasibility for both materials and the full-scale beams and CO2 reduction methods, including use of recycled concrete aggregate, ground granulated blast-furnace and silica fume to replace natural coarseaggregates and Ordinary Portland Cement. Guidance for testing HPCBs—including setup, test procedure and data collection and interpretation—is also given. The authors also elaborate on recommendations for finite element analysis for HPCBs. Design examples are appended to illustrate typical current practice using a 12 × 12 m grid floor with live load of 15 kPa. Various considerations for different parameters such as fire resistance are discussed. Finally, the authors present a case study of a recently completed industrial building in Singapore to quantify the benefits of using HPCBs over reinforced concrete and conventional composite construction.Structural engineering professionals, whose work relates to long-span and heavy-loading industrial or commercial buildings, will benefit from the detailed guidance and focus on practical applications provided throughout this book. Post-graduate students of advanced steel and composite structures will also benefit from these descriptions.

Persistently high rates of youth unemployment have been a global concern for more than two decades. One in five young people is not currently in education, employment, or training; and women, minorities, and individuals in lower socioeconomic populations are among the most vulnerable to becoming unemployed.   This volume of The ANNALS examines the causes, patterns, and consequences of labor market uncertainties for young adults around the world. Focusing on regional inequalities and widespread trends, this volume both highlights the importance of youth integration into labor markets and outlines policy changes that are crucial for this integration to be successful.

Persistently high rates of youth unemployment have been a global concern for more than two decades. One in five young people is not currently in education, employment, or training; and women, minorities, and individuals in lower socioeconomic populations are among the most vulnerable to becoming unemployed.   This volume of The ANNALS examines the causes, patterns, and consequences of labor market uncertainties for young adults around the world. Focusing on regional inequalities and widespread trends, this volume both highlights the importance of youth integration into labor markets and outlines policy changes that are crucial for this integration to be successful.

Fluctuation Mechanism and Control on System Instantaneous Availability facilitates the development of modeling and identification skills for both theoretical research and applications. Supplying a systematic introduction to the basic results in fluctuation analysis of instantaneous availability, it covers the theory, methodology, and specific engineering implementation required to conduct equipment instantaneous availability research.Presenting practical methods and tools, the book describes how to control the matching transition of new equipment systems as a result of interactions among sub-systems. It will help readers further extend their research on steady-state availability analysis to the optimization and control over instantaneous availability that is more suitable for engineering practices.The book provides the in-depth research on system instantaneous availability models, solutions, methodology, and frameworks required to investigate system instantaneous availability fluctuations within a certain range. Its chapters are divided into "Basic" and "Applied" components.The Basic chapters introduce the relevant concepts about system availability, the general continuous availability model approximate solution algorithms and problems, the discrete-time systems instantaneous availability model under general probability distribution, and the system instantaneous availability model and stability proof constraint by limited time, respectively.The Applied chapters focus on system instantaneous availability fluctuation analysis and control methods, discrete-time instantaneous availability model comparison and analysis under exponential distribution, system instantaneous availability fluctuations analysis under truncated discrete Weibull distribution, and system instantaneous availability fluctuations optimal design under truncated discrete Weibull distribution.Presenting the material in an accessible manner, the book summarizes current research results and engineering practices. It includes many examples that illustrate the roles of the new modeling methods for instantaneous availability. It also supplies Matlab® code for all the calculations performed in the book.

Fluctuation Mechanism and Control on System Instantaneous Availability facilitates the development of modeling and identification skills for both theoretical research and applications. Supplying a systematic introduction to the basic results in fluctuation analysis of instantaneous availability, it covers the theory, methodology, and specific engineering implementation required to conduct equipment instantaneous availability research.Presenting practical methods and tools, the book describes how to control the matching transition of new equipment systems as a result of interactions among sub-systems. It will help readers further extend their research on steady-state availability analysis to the optimization and control over instantaneous availability that is more suitable for engineering practices.The book provides the in-depth research on system instantaneous availability models, solutions, methodology, and frameworks required to investigate system instantaneous availability fluctuations within a certain range. Its chapters are divided into "Basic" and "Applied" components.The Basic chapters introduce the relevant concepts about system availability, the general continuous availability model approximate solution algorithms and problems, the discrete-time systems instantaneous availability model under general probability distribution, and the system instantaneous availability model and stability proof constraint by limited time, respectively.The Applied chapters focus on system instantaneous availability fluctuation analysis and control methods, discrete-time instantaneous availability model comparison and analysis under exponential distribution, system instantaneous availability fluctuations analysis under truncated discrete Weibull distribution, and system instantaneous availability fluctuations optimal design under truncated discrete Weibull distribution.Presenting the material in an accessible manner, the book summarizes current research results and engineering practices. It includes many examples that illustrate the roles of the new modeling methods for instantaneous availability. It also supplies Matlab® code for all the calculations performed in the book.

Improvement of injection molding processes remains a topic of great interest in both industry and research institutions. This book introduces the analysis of the molding process from a systems technology point of view.It is divided into four parts: the first part provides general background to introduce the injection molding process, the second covers the control of the process, the third is on the monitoring technology, and the fourth is concerned with the optimization of the process. Most the results within are from real engineering implementations and experimental tests.With the purchase of this book, you also receive a free personal access code to download the eBook.

The last chapter presents several enlightening scenarios of fractional-order control designs, for example, the suppression of machining chatter, the nonlinear motion control of a multilink robot, the simultaneous tracking and stabilization control of a rotary inverted pendulum, and the idle speed control of an internal combustion engine (ICE).

This book summarizes the recent advancements for drug delivery systems (DDS) in terms of fundamental principles, rapidly emerging techniques and developing frontiers of molecular imprinting. Especially with the combination of enantioselective molecularly imprinted polymers and water compatible molecularly imprinted polymers, stimuli responsive imprinted DDS have been innovated and applied to dermal delivery, ophthalmic drugs and cancer treatment. This philosophy comprehensively revolutionizes the treatment strategy of human healthcare and provides the possibility to re-trigger in vivo an exhaust system after the complete release of the starting drug cargo, thus enabling precision medicine.To this end, the following unique features will be discussed and concluded:1) State-of-the-art definition of MIP as drug delivery systems.2) Advanced techniques and clinical applications of MIP as drug delivery systems in the past decade.3) Novel frontiers and brand-new technologies, for example, drug delivery devices for zero-order sustained release and stimuli responsive imprinted DDS.4) Revolutionary impact on dermal delivery, ophthalmic drugs and cancer treatment.5) Future challenges and perspectives

This book summarizes the recent advancements for drug delivery systems (DDS) in terms of fundamental principles, rapidly emerging techniques and developing frontiers of molecular imprinting. Especially with the combination of enantioselective molecularly imprinted polymers and water compatible molecularly imprinted polymers, stimuli responsive imprinted DDS have been innovated and applied to dermal delivery, ophthalmic drugs and cancer treatment. This philosophy comprehensively revolutionizes the treatment strategy of human healthcare and provides the possibility to re-trigger in vivo an exhaust system after the complete release of the starting drug cargo, thus enabling precision medicine.To this end, the following unique features will be discussed and concluded:1) State-of-the-art definition of MIP as drug delivery systems.2) Advanced techniques and clinical applications of MIP as drug delivery systems in the past decade.3) Novel frontiers and brand-new technologies, for example, drug delivery devices for zero-order sustained release and stimuli responsive imprinted DDS.4) Revolutionary impact on dermal delivery, ophthalmic drugs and cancer treatment.5) Future challenges and perspectives

This book focuses on the various functional properties and potential applications of one-dimensional ZnO nanostructures, from basic principles to our most recent discoveries. It comprises experimental analysis of various properties of ZnO nanostructures, preparation techniques, research methods, and some promising applications. The areas of focus include ZnO-based gas/biochemical sensing devices, field emitters, solar cells, light-emitting diodes, e-papers, and single-nanowire-based transistors.