Yizheng Wang – författare
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2 produkter
2 produkter
1 434 kr
Kommande
This book equips readers with a rigorous and practical framework for solving complex engineering problems directly from governing equations using modern machine learning techniques. It bridges established principles from mechanics, numerical analysis, and scientific computing with emerging physics-based learning approaches, enabling reliable modeling, simulation, optimization, and inverse analysis beyond purely data-driven methods. A distinctive feature is its critical comparison of machine learning-based solvers with classical techniques such as the finite element method, isogeometric analysis, and meshfree methods, highlighting strengths, limitations, and domains of applicability. The scope ranges from foundational concepts to advanced engineering applications, supported by worked examples, reproducible code, and extensive references. The book is intended for graduate students, researchers, and practitioners in engineering, applied mathematics, and computational sciences who seek a principled entry point and a state-of-the-art reference for physics-based machine learning in modeling and simulation.
Del 976 - Advances in Experimental Medicine and Biology
Transient Receptor Potential Canonical Channels and Brain Diseases
Inbunden, Engelska, 2017
1 745 kr
Skickas inom 10-15 vardagar
This book discusses the latest findings on the physiological and pathological functions of transient receptor potential canonical/classical (TRPC) proteins in the brain. In addition to reviewing the functions of TRPCs in brain development and neuron transmission, it mainly covers the potential roles of TRPCs in brain disorders. TRPC proteins belong to the TRP channel superfamily, which has around 30 members. Just like TRP channels, TRPCs are non-selectively permeable to cations, with a selectivity of calcium over sodium that varies among different members. The TRPC subfamily consists of six members, grouped on the basis of the similarities in gene sequence and protein structure in mammalians. What sets TRPCs apart from other subfamilies in TRPs is that their activation, stimulated by a membrane receptor-phospholipid C (PLC) cascade, contributes to the slow and sustained elevation of intracellular free calcium. Calcium ions, one of the most important types of second messengers, mediate a variety of physiological functions in the brain, including progenitor cell proliferation, dendritic formation, synaptic transmission and neuronal survival. All TRPCs except TRPC7 have been found in various regions of the brain, including the cerebrum, cerebellum, forebrain and hippocampus. This book provides students and investigators with comprehensive information on the regulation, function and potential of TRPCs and brain diseases in order to attract more attention to this field.