Yogeshwar Bachhav – författare

Targeted Drug Delivery Novel approaches in targeted drug delivery for both small molecule and biopharmaceutical drugs Targeted Drug Delivery explores a new frontier in drug research that has become a focus for developing novel medications. The work discusses a wide range of approaches for targeting small molecules as well as peptide and macromolecular drugs, from prodrugs to drug conjugates to drug carriers and devices, helping readers to stay up to date on the latest developments in the field. The following key topics are addressed: Antibody conjugates, prodrugs, and suicide gene therapeuticsProtac technology for selectively degrading target proteinsDelivery of nucleic acid drugsNovel drug carriers, such as liposomes, vesicles, and nanoparticlesUnmet medical needs for which there is a large market potential, such as viral infections and cancerFor chemists, pharmacologists, and professionals in the wider pharmaceutical industry, Targeted Drug Delivery is a comprehensive guide on how to solve the greatest challenge in treating many diseases: delivering a pharmaceutically active substance to the target tissue in the body.

Ten proven strategies to overcome solubility challenges in drug development Poor water solubility prevents drug candidates from reaching their therapeutic targets, causing promising compounds to fail during development. Drug Development Approaches for Poorly Soluble Compounds presents ten distinct strategies for overcoming this challenge, from altering drug structure and creating prodrugs to formulation techniques using nanosuspensions, microemulsions, micelles, co-crystals, and co-solvents. Each approach includes case studies from current pharmaceutical industry projects. This reference covers strategies applicable to virtually every drug type, regardless of molecular size or chemical composition. Beyond formulation science, the book addresses solubility-related commercial and regulatory considerations essential for bringing drugs to market. Special attention is given to animal study requirements for poorly soluble compounds. Each chapter demonstrates approaches through examples from recent pharmaceutical development projects across small and large companies. Readers will also find: Detailed explanations of ten formulation strategies including nanosuspensions, microemulsions, micelles, co-crystals, and co-solvent approaches for enhancing drug solubilityPractical case studies drawn from recent pharmaceutical industry drug development projects demonstrating real-world applications of each solubility enhancement strategyGuidance on regulatory considerations specific to poorly soluble compounds, helping developers navigate approval pathways more efficiently throughout the development processCoverage of special requirements for conducting animal studies with compounds that exhibit poor solubility in biological fluidsCommercial considerations for solubility enhancement strategies that reduce required drug substance amounts, lowering costs and minimizing potential side effectsDesigned for medicinal chemists, pharmaceutical chemists, pharmacologists, and pharmaceutical industry professionals, this book ensures no drug candidate fails due to solubility challenges. The strategies presented here apply across compound types and development stages, providing practitioners with proven solutions for this common development obstacle.

Teaches future and current drug developers the latest innovations in drug formulation design and optimization This highly accessible, practice-oriented book examines current approaches in the development of drug formulations for preclinical and clinical studies, including the use of functional excipients to enhance solubility and stability. It covers oral, intravenous, topical, and parenteral administration routes. The book also discusses safety aspects of drugs and excipients, as well as regulatory issues relevant to formulation. Innovative Dosage Forms: Design and Development at Early Stage starts with a look at the impact of the polymorphic form of drugs on the preformulation and formulation development. It then offers readers reliable strategies for the formulation development of poorly soluble drugs. The book also studies the role of reactive impurities from the excipients on the formulation shelf life; preclinical formulation assessment of new chemical entities; and regulatory aspects for formulation design. Other chapters cover innovative formulations for special indications, including oncology injectables, delayed release and depot formulations; accessing pharmacokinetics of various dosage forms; physical characterization techniques to assess amorphous nature; novel formulations for protein oral dosage; and more. -Provides information that is essential for the drug development effort -Presents the latest advances in the field and describes in detail innovative formulations, such as nanosuspensions, micelles, and cocrystals -Describes current approaches in early pre-formulation to achieve the best in vivo results -Addresses regulatory and safety aspects, which are key considerations for pharmaceutical companies -Includes case studies from recent drug development programs to illustrate the practical challenges of preformulation design Innovative Dosage Forms: Design and Development at Early Stage provides valuable benefits to interdisciplinary drug discovery teams working in industry and academia and will appeal to medicinal chemists, pharmaceutical chemists, and pharmacologists.

Teaches future and current drug developers the latest innovations in drug formulation design and optimization This highly accessible, practice-oriented book examines current approaches in the development of drug formulations for preclinical and clinical studies, including the use of functional excipients to enhance solubility and stability. It covers oral, intravenous, topical, and parenteral administration routes. The book also discusses safety aspects of drugs and excipients, as well as regulatory issues relevant to formulation. Innovative Dosage Forms: Design and Development at Early Stage starts with a look at the impact of the polymorphic form of drugs on the preformulation and formulation development. It then offers readers reliable strategies for the formulation development of poorly soluble drugs. The book also studies the role of reactive impurities from the excipients on the formulation shelf life; preclinical formulation assessment of new chemical entities; and regulatory aspects for formulation design. Other chapters cover innovative formulations for special indications, including oncology injectables, delayed release and depot formulations; accessing pharmacokinetics of various dosage forms; physical characterization techniques to assess amorphous nature; novel formulations for protein oral dosage; and more. -Provides information that is essential for the drug development effort -Presents the latest advances in the field and describes in detail innovative formulations, such as nanosuspensions, micelles, and cocrystals -Describes current approaches in early pre-formulation to achieve the best in vivo results -Addresses regulatory and safety aspects, which are key considerations for pharmaceutical companies -Includes case studies from recent drug development programs to illustrate the practical challenges of preformulation design Innovative Dosage Forms: Design and Development at Early Stage provides valuable benefits to interdisciplinary drug discovery teams working in industry and academia and will appeal to medicinal chemists, pharmaceutical chemists, and pharmacologists.

Targeted Drug Delivery

Novel approaches in targeted drug delivery for both small molecule and biopharmaceutical drugs

Targeted Drug Delivery explores a new frontier in drug research that has become a focus for developing novel medications. The work discusses a wide range of approaches for targeting small molecules as well as peptide and macromolecular drugs, from prodrugs to drug conjugates to drug carriers and devices, helping readers to stay up to date on the latest developments in the field.

The following key topics are addressed:

Antibody conjugates, prodrugs, and suicide gene therapeutics Protac technology for selectively degrading target proteins Delivery of nucleic acid drugs Novel drug carriers, such as liposomes, vesicles, and nanoparticles Unmet medical needs for which there is a large market potential, such as viral infections and cancer

For chemists, pharmacologists, and professionals in the wider pharmaceutical industry, Targeted Drug Delivery is a comprehensive guide on how to solve the greatest challenge in treating many diseases: delivering a pharmaceutically active substance to the target tissue in the body.

Targeted Drug Delivery

Novel approaches in targeted drug delivery for both small molecule and biopharmaceutical drugs

Targeted Drug Delivery explores a new frontier in drug research that has become a focus for developing novel medications. The work discusses a wide range of approaches for targeting small molecules as well as peptide and macromolecular drugs, from prodrugs to drug conjugates to drug carriers and devices, helping readers to stay up to date on the latest developments in the field.

The following key topics are addressed:

Antibody conjugates, prodrugs, and suicide gene therapeutics Protac technology for selectively degrading target proteins Delivery of nucleic acid drugs Novel drug carriers, such as liposomes, vesicles, and nanoparticles Unmet medical needs for which there is a large market potential, such as viral infections and cancer

For chemists, pharmacologists, and professionals in the wider pharmaceutical industry, Targeted Drug Delivery is a comprehensive guide on how to solve the greatest challenge in treating many diseases: delivering a pharmaceutically active substance to the target tissue in the body.

Ten proven strategies to overcome solubility challenges in drug development Poor water solubility prevents drug candidates from reaching their therapeutic targets, causing promising compounds to fail during development. Drug Development Approaches for Poorly Soluble Compounds presents ten distinct strategies for overcoming this challenge, from altering drug structure and creating prodrugs to formulation techniques using nanosuspensions, microemulsions, micelles, co-crystals, and co-solvents. Each approach includes case studies from current pharmaceutical industry projects. This reference covers strategies applicable to virtually every drug type, regardless of molecular size or chemical composition. Beyond formulation science, the book addresses solubility-related commercial and regulatory considerations essential for bringing drugs to market. Special attention is given to animal study requirements for poorly soluble compounds. Each chapter demonstrates approaches through examples from recent pharmaceutical development projects across small and large companies. Readers will also find: Detailed explanations of ten formulation strategies including nanosuspensions, microemulsions, micelles, co-crystals, and co-solvent approaches for enhancing drug solubility Practical case studies drawn from recent pharmaceutical industry drug development projects demonstrating real-world applications of each solubility enhancement strategy Guidance on regulatory considerations specific to poorly soluble compounds, helping developers navigate approval pathways more efficiently throughout the development process Coverage of special requirements for conducting animal studies with compounds that exhibit poor solubility in biological fluids Commercial considerations for solubility enhancement strategies that reduce required drug substance amounts, lowering costs and minimizing potential side effects Designed for medicinal chemists, pharmaceutical chemists, pharmacologists, and pharmaceutical industry professionals, this book ensures no drug candidate fails due to solubility challenges. The strategies presented here apply across compound types and development stages, providing practitioners with proven solutions for this common development obstacle.