Young-Joon Surh - Böcker

Curcumin is derived from the root of the plant Curcuma longa (also called turmeric) and its medicinal uses have been described for over 5000 years. More than 1500 papers published within last half a century has revealed that curcumin has a potential in the treatment of wide variety of inflammatory diseases including cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer, psoriasis etc, through modulation of numerous molecular targets. This is the first monograph to deal specifically with this subject.

Specifically focusing on the redox regulation of cell signaling responsible for oxidative stress and inflammatory tissue damage, this reference provides a comprehensive overview of cutting-edge research on the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes induced by endogenous and xenobiotic factors-analyzing the implications of oxidative stress and inflammatory damage in the pathogenesis of human disorders such as cancer, neurodegenerative disease, and diabetes.

A consequence of rapid progress in the science of nutrigenomics and nutrigenetics is the substantial accumulation of data covering nutrienal modulation of gene expression at the cellular and subcellular levels. Current research is increasingly focused on the role of nutrition and diet in modifying oxidative damage in the progression of disease. Dietary Modulation of Cell Signaling Pathways reviews some of these findings, focusing on nutrient-gene interactions with particular emphasis on the intracellular signaling network.Explore a Pivotal Function for Maintaining HomeostasisThe book addresses the dietary modulation of particular gene expression systems and highlights the underlying molecular and cellular mechanisms that involve upstream signaling molecules, such as kinases and transcription factors in the context of their therapeutic potential. It describes nutrients’ actions on the activation of an antioxidant and inflammatory transcription factor and the induction of their target gene expression. Provides a Mechanistic Understanding of the Action of Dietary ComponentsComprehensively covering dietary modulation of cell signaling, leading experts provide information on state-of-the-art research in their own specialty. For those working in the fields of dietary components, molecular mechanisms, and health benefits, this book presents a useful tool for mechanistic understanding of the action of dietary components.

Curcumin is derived from the root of the plant Curcuma longa (also called turmeric) and its medicinal uses have been described for over 5000 years. More than 1500 papers published within last half a century has revealed that curcumin has a potential in the treatment of wide variety of inflammatory diseases including cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer, psoriasis etc, through modulation of numerous molecular targets. This is the first monograph to deal specifically with this subject.

Recently, much attention has been focused on aging and obesity and the pivotal roles these conditions play in the development of chronic diseases such as diabetes, hypertension, and cancer.  Several preclinical and clinical studies have revealed associations between aging and obesity and altered celluar environments––including genetic changes and inflammation–in the pathogenesis of many chronic disorders. Conventional methods for the treatment of cancer, including surgery, chemotherapy, and radiotherapy, result in limited success in certain cases and demonstrate additional modalities are required. In contrast to conventional treatments, some recent strategies are shifting to cancer prevention and treatment through physical exercise and better nutrition to control tumor progression, and to improve prognosis and rehabilitation in some cancer patients. This Annals volume presents a series of short reviews that focus on recent advances in, and future directions for, physical and nutritional bio-modulation and prevention of aging, obesity, and cancer, and suggest clinical care guidelines for the general population and for cancer patients and survivors who need proper physical exercise and optimal nutrition.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.