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2 produkter
2 produkter
Transporters in Drug Discovery and Development
Detailed Concepts and Best Practice
Inbunden, Engelska, 2026
2 582 kr
Kommande
Transporters in Drug Discovery and Development: Detailed Concepts and Best Practice, 2nd Edition is a comprehensive book providing a detailed overview of significant drug transporter families, their roles in disease causation due to functional defects, and their importance in drug discovery and development. Building upon the foundation set by the first edition, this updated version covers various topics, including clinically relevant drug transporter-related pharmacokinetics variations, drug-drug interactions (DDIs), genetic polymorphisms, transporter-related organ toxicity, and methodologies for studying drug transporters. It also highlights the translational aspect in drug discovery and development. The revision explores the advancements in transporter research, such as the emerging use of transporters as pharmacological targets, the evolving application of modeling and simulation, and the innovative use of endogenous biomarkers in assessing transporter activities during drug clinical trials. Transporters in Drug Discovery and Development: Detailed Concepts and Best Practice, 2nd Edition provides a deeper understanding of transporter research and its implications. It is an invaluable resource for researchers, students, and professionals in the field, offering insights that could potentially revolutionize drug discovery and development.
Transporters in Drug Discovery and Development
Detailed Concepts and Best Practice
Inbunden, Engelska, 2013
2 582 kr
Skickas inom 7-10 vardagar
Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments. A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and development Balanced coverage of molecular biology aspects and functional outcomes State of art knowledge related to transporter-mediated DDI and the clinical relevance in pharmacokinetics, dynamics, and toxicity