Yves Agid – författare

Glial cells play an essential role in initiating and controlling our behaviours, playing a major role in communication between brain cells. They share certain properties with neurons, including the ability to use information from the environment to formulate behaviors. Understanding these cells is key to explaining human movement, emotion, and thoughts. Moreover, glial cells provide a panoply of new therapeutic targets for the treatment of neuropsychiatric disorders.This book is the ''brain'' child of two scientist physicians: Pierre Magistretti, a leading expert in cerebral metabolism and glial cell biology, and Yves Agid, an expert in the treatment of nervous system diseases and a researcher in the field of neurodegenerative diseases. This book provides many examples of the decisive role glial cells play in the functioning of the human brain, as well as in neurological and psychiatric pathologies.The result is a revolution in our understanding of the brain and a beacon of hope in the treatment of neuropsychiatric disorders.

Glial cells play an essential role in initiating and controlling our behaviours, playing a major role in communication between brain cells. They share certain properties with neurons, including the ability to use information from the environment to formulate behaviors. Understanding these cells is key to explaining human movement, emotion, and thoughts. Moreover, glial cells provide a panoply of new therapeutic targets for the treatment of neuropsychiatric disorders.This book is the ''brain'' child of two scientist physicians: Pierre Magistretti, a leading expert in cerebral metabolism and glial cell biology, and Yves Agid, an expert in the treatment of nervous system diseases and a researcher in the field of neurodegenerative diseases. This book provides many examples of the decisive role glial cells play in the functioning of the human brain, as well as in neurological and psychiatric pathologies.The result is a revolution in our understanding of the brain and a beacon of hope in the treatment of neuropsychiatric disorders.

Glial cells play an essential role in initiating and controlling our behaviours, playing a major role in communication between brain cells. They share certain properties with neurons, including the ability to use information from the environment to formulate behaviors. Understanding these cells is key to explaining human movement, emotion, and thoughts. Moreover, glial cells provide a panoply of new therapeutic targets for the treatment of neuropsychiatric disorders.This book is the 'brain' child of two scientist physicians: Pierre Magistretti, a leading expert in cerebral metabolism and glial cell biology, and Yves Agid, an expert in the treatment of nervous system diseases and a researcher in the field of neurodegenerative diseases. This book provides many examples of the decisive role glial cells play in the functioning of the human brain, as well as in neurological and psychiatric pathologies.The result is a revolution in our understanding of the brain and a beacon of hope in the treatment of neuropsychiatric disorders.

We are conscious of only a small fraction of our lives. Because the brain constantly receives an enormous quantity of information, we need to be able to do things without thinking about them—to act in “autopilot” mode. Automatic behaviors—the vast majority of our activities—occur without our conscious awareness, or subconsciously. Yet the physiological basis of subconsciousness remains poorly understood, despite its vast importance for physical and mental health.The neurodegenerative disease expert Yves Agid offers a groundbreaking and accessible account of subconsciousness and its significance. He pinpoints the basal ganglia—the ancient “basement of the brain”—as the main physiological hub of the subconscious. Agid examines its roles in the control and production of automatic behavior, including motor, intellectual, and emotional processes. He highlights the consequences for various brain pathologies, showing how malfunctions of the subconscious have clinical repercussions including not only abnormal involuntary movements, as seen in Parkinson’s disease, but also psychiatric disorders such as obsessive-compulsive disorders and depression. Based on this understanding, Agid considers how seeing the basal ganglia as a therapeutic target can aid development of potential new treatments for neurological and psychiatric disorders.Shedding new light on the physiological bases of our behavior and mental states, this book provides an innovative exploration of the complexities of the mind, with implications ranging from clinical applications to philosophy’s thorniest problems.

We are conscious of only a small fraction of our lives. Because the brain constantly receives an enormous quantity of information, we need to be able to do things without thinking about them—to act in “autopilot” mode. Automatic behaviors—the vast majority of our activities—occur without our conscious awareness, or subconsciously. Yet the physiological basis of subconsciousness remains poorly understood, despite its vast importance for physical and mental health.The neurodegenerative disease expert Yves Agid offers a groundbreaking and accessible account of subconsciousness and its significance. He pinpoints the basal ganglia—the ancient “basement of the brain”—as the main physiological hub of the subconscious. Agid examines its roles in the control and production of automatic behavior, including motor, intellectual, and emotional processes. He highlights the consequences for various brain pathologies, showing how malfunctions of the subconscious have clinical repercussions including not only abnormal involuntary movements, as seen in Parkinson’s disease, but also psychiatric disorders such as obsessive-compulsive disorders and depression. Based on this understanding, Agid considers how seeing the basal ganglia as a therapeutic target can aid development of potential new treatments for neurological and psychiatric disorders.Shedding new light on the physiological bases of our behavior and mental states, this book provides an innovative exploration of the complexities of the mind, with implications ranging from clinical applications to philosophy’s thorniest problems.

This book gives the reader an up-to-date, clear and logical idea of what caring for parkinsonian patients entails - a challenge that clinicians will face for many years to come. It is split into three sections: Section 1: A compilation of the major brain lesions typically seen in PDSection 2: Treatment options in PDSection 3: 25 cases designed to test the reader and the practical application of the information supplied in the other sections.

This book gives the reader an up-to-date, clear and logical idea of what caring for parkinsonian patients entails - a challenge that clinicians will face for many years to come. It is split into three sections:

Section 1: A compilation of the major brain lesions typically seen in PD

Section 2: Treatment options in PD

Section 3: 25 cases designed to test the reader and the practical application of the information supplied in the other sections.

A state-of-the-art review of the many cognitive, affective, and behavioral dysfunctions associated with movement disorders. These dysfunctions include depression, dementia, psychosis, sleep disorders arising from Parkinson's and Huntington's disease, Tourette's syndrome, as well as multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and many other related disorders. The authors describe these behavioral syndromes and their neurophysiological and neuropathological substratum, as well as their diagnostic criteria and therapeutic guidelines. The cognitive and affective dysfunctions are spelled out in detail.

A state-of-the-art review of the many cognitive, affective, and behavioral dysfunctions associated with movement disorders. These dysfunctions include depression, dementia, psychosis, sleep disorders arising from Parkinson's and Huntington's disease, Tourette's syndrome, as well as multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and many other related disorders. The authors describe these behavioral syndromes and their neurophysiological and neuropathological substratum, as well as their diagnostic criteria and therapeutic guidelines. The cognitive and affective dysfunctions are spelled out in detail.

Ce livre renouvelle profondément ce que l’on sait sur le fonctionnement du cerveau. Les cellules gliales ont non seulement certaines des propriétés des neurones, mais elles ont la capacité d’intégrer les messages apportés à partir de l’environnement pour produire un comportement. C’est dire combien elles sont importantes à considérer pour expliquer nos mouvements, nos émotions, nos pensées et combien elles sont des cibles thérapeutiques potentielles pour lutter contre les maladies du cerveau. Conçu par deux scientifiques-médecins, l’un grand connaisseur du métabolisme cérébral et de la biologie des cellules gliales – Pierre Magistretti –, l’autre spécialiste de la prise en charge des maladies du système nerveux et de la recherche sur les maladies neurodégénératives – Yves Agid –, cet ouvrage fourmille d’exemples ; il montre le rôle décisif des cellules gliales dans le fonctionnement du cerveau de l’homme et, aussi, dans les pathologies neurologiques et psychiatriques. Une révolution dans la compréhension du cerveau, en même temps qu’une immense source d’espoir dans le traitement des maladies neuropsychiatriques. Yves Agid est professeur émérite de neurologie et de biologie cellulaire à l’université Paris-VI. Membre de l’Académie des sciences, membre fondateur de l’Institut du cerveau et de la moelle épinière (ICM), il est spécialiste de la recherche clinique et biologique sur les maladies neurodégénératives. Pierre Magistretti, médecin et neuroscientifique, est professeur à l’École polytechnique fédérale de Lausanne (EPFL), à l’Université de Lausanne et à la King Abdullah University of Science and Technology (KAUST). Il est dans le monde l’un des pionniers dans la recherche sur la glie. Avec François Ansermet, ils ont publié À chacun son cerveau (2004) et Les Énigmes du plaisir (2010) ; ils ont aussi dirigé le collectif Neurosciences et psychanalyse (2010).

Dans ce livre, le professeur Yves Agid, neurologue, spécialiste des maladies du cerveau, nous montre que vieillir ne dépend pas seulement du temps qui passe : vieillir dépend surtout de notre cerveau. À partir de sa longue expérience clinique et scientifique, il nous expose sans langue de bois, mais toujours avec humour, les progrès réalisés dans la compréhension et le traitement des maladies neuro-dégénératives. Si on veut améliorer le bien-être des personnes âgées, il faut comprendre ce qu’on appelle vieillir : quels sont les fondements biologiques du vieillissement ? Et puisque le cerveau est en première ligne, comment se traduit le vieillissement cérébral ? En fait, vieillir n’est pas une maladie. C’est la vie tout simplement. Peut-être la plus importante partie de l’existence, et qu’on peut vivre intensément ! Yves Agid est professeur émérite de neurologie et de biologie cellulaire à l’université Paris-Sorbonne. Membre de l’Académie des sciences, membre fondateur de l’Institut du cerveau et de la moelle épinière (ICM), c’est un spécialiste de la recherche sur les maladies neurodégénératives. Il est notamment l’auteur, avec Pierre Magistretti, de L’Homme glial, qui est un grand succès.