Zachary T. Sample – författare

This book provides practical, comprehensive knowledge on how to use the advances in analytical measurements and basic and advanced control to improve batch profiles and endpoint consistency. The consequential integration of measurements, models, and controls into a digital twin with recently developed blocks to provide profiles and predict endpoints enables:Developing dynamic models from trend charts that are used for experiment design, diagnosing the sources of limitations and inconsistences, and developing and testing solutions 500 times real time without interfering with existing plant operation.Comprehensive views of basic process control with the possibilities of model predictive control to control and optimize batch profiles by non-intrusive development and confirmation.The ability to determine how to maximize the performance of bioreactors, which are often the bottleneck and the key to product quality and consistency, without tests or trials in the actual plant.The resulting improvements in batch cycle time and consistency can be designed, tested, quantified, and confirmed; and operators can be trained independently of actual plant operation. The benefit from the elimination of a bad batch—particularly for new biologics—is potentially worth ten or more million dollars.

New Directions in Bioprocess Modeling and Control: Maximizing Process Analytical Technology Benefits, 2nd Edition This book provides practical, comprehensive knowledge on how to use the advances in analytical measurements and basic and advanced control to improve batch profiles and endpoint consistency. The consequential integration of measurements, models, and controls into a digital twin with recently developed blocks to provide profiles and predict endpoints enables: Developing dynamic models from trend charts that are used for experiment design, diagnosing the sources of limitations and inconsistences, and developing and testing solutions 500 times real time without interfering with existing plant operation. Comprehensive views of basic process control with the possibilities of model predictive control to control and optimize batch profiles by non-intrusive development and confirmation. The ability to determine how to maximize the performance of bioreactors, which are often the bottleneck and the key to product quality and consistency, without tests or trials in the actual plant. The resulting improvements in batch cycle time and consistency can be designed, tested, quantified, and confirmed; and operators can be trained independently of actual plant operation. The benefit from the elimination of a bad batch particularly for new biologics is potentially worth ten or more million dollars.

Advanced pH Measurement and Control: Digital Twin Synergy and Advances in Technology details system design, installation, maintenance and ongoing improvement, including a special focus on how digital twins and first-principles charge balance contribute to innovation, operability, productivity, reliability and maintainability. It offers insights into key principles and advances in electrode technology and diagnostics, including a simple and largely untapped method for computing titration curves that match laboratory curves, as well as guidance on selecting and implementing the best control valves and strategies. The extraordinary sensitivity and rangeability of pH used for measuring and controlling hydrogen concentration introduce many challenges in managing the nonlinearity in the control loop and the precision needed for the control valve. This, combined with pH's critical role in maintaining cell health in biological processes, as well as in the production of clean water, food, pharmaceuticals and chemicals, makes the best pH control system particularly important and challenging. Despite these challenges, the outcomes can lead to significant reductions in equipment costs and, more importantly, substantial improvements in system reliability and performance. Finally, the appendices cover fundamental principles and provide guidance on using new PID features to reduce project costs and maximize process efficiency, capacity and safety.