Zhongwu Guo – författare

Glycosphingolipids in the Central Nervous System: Diversity in Structure, Metabolism, Distribution, and Function comprehensively covers progress made in the discovery, profiling and understanding of the metabolism, function and functional mechanism of GSLs in the CNS -as well as their synthesis, relationships with and therapeutic applications to neurodegenerative disorders, and related CNS diseases. Due to the important roles of GSLs in the CNS and various CNS-related diseases, the interest in these biomolecules is growing. GSLs are the principal glycolipids on the cell surface and an essential constituent of the cell membrane.

They are widespread, but especially enriched in the central nervous system (CNS) in vertebrates. The diversity of GSL structures forges the molecular foundation for their broad spectrum of activity.

Presents a systematic review of literature and potential future developments in Glycosphingolipid research Highlights interdisciplinary interplay between various aspects of the neuronal system and its structural and functional properties Provides an overview, general trends, cases studies, summaries and future implications

Glycosphingolipids in the Central Nervous System: Diversity in Structure, Metabolism, Distribution, and Function comprehensively covers progress made in the discovery, profiling and understanding of the metabolism, function and functional mechanism of GSLs in the CNS –as well as their synthesis, relationships with and therapeutic applications to neurodegenerative disorders, and related CNS diseases. Due to the important roles of GSLs in the CNS and various CNS-related diseases, the interest in these biomolecules is growing. GSLs are the principal glycolipids on the cell surface and an essential constituent of the cell membrane.They are widespread, but especially enriched in the central nervous system (CNS) in vertebrates. The diversity of GSL structures forges the molecular foundation for their broad spectrum of activity.- Presents a systematic review of literature and potential future developments in Glycosphingolipid research- Highlights interdisciplinary interplay between various aspects of the neuronal system and its structural and functional properties- Provides an overview, general trends, cases studies, summaries and future implications

The fundamental science and the latest developments in carbohydrate-based vaccinesThe relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments.With contributions by leading experts, this resource covers the design, synthesis, evaluation, and applications of various carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids. The text approaches vaccine design from a chemical and molecular focus, staying in line with current advances.Key topics covered by Carbohydrate-Based Vaccines and Immunotherapies include: Recent developments towards clinically useful vaccines against bacteria, viruses, parasites, and fungiUsing adjuvants to improve immunogenicity and/or immunological properties of vaccinesChoosing and designing proper adjuvants for specific targetsAbnormal carbohydrates expressed by tumorsCarbohydrate-based therapeutic cancer vaccines or cancer immunotherapyClinical trials results for synthetic cancer vaccinesGlycoengineering of cell surface carborhydrates and its anticancer applicationsUsing cell surface carbohydrates for disease diagnosisA single, convenient source of state-of-the-art information from leading authorities in the field, Carbohydrate-Based Vaccines and Immunotherapies is an essential reference for organic chemists and biochemists, academic researchers, and other students and professionals involved in vaccine design.