Michele I. Morris, M.D., FACP, FIDSA, FASTProfessor of Clinical MedicineDirector, Immunocompromised Host ServiceDivision of Infectious DiseasesUniversity of Miami Miller School of Medicine1120 N.W. 14th St., Suite 842 (R-21)Miami, FL 33136Camille Nelson Kotton MD, FIDSA, FASTClinical Director, Transplant and Immunocompromised Host Infectious DiseasesInfectious Diseases DivisionMassachusetts General Hospital Harvard Medical School55 Fruit Street, Cox 5Boston, MA 02114 USADr Cameron R.Wolfe MBBS(Hons), MPH, FIDSAAssociate Professor of MedicineTransplant Infectious DiseaseDUMC #102359, Rm 159,Hanes House, Trent DriveDurham, NC, 27710Michele I. Morris, M.D., FIDSA, FAST, is Professor of Clinical Medicine and Director of the Immunocompromised Host Service in the Division of Infectious Diseases at the University of Miami Miller School of Medicine. She has spent the last 17 years of her career focusing her clinical practice and research efforts on transplant infectious diseases, with special attention to the area of emerging infections in transplant. Dr. Morris is also Medical Director of Infection Control and Antimicrobial Stewardship at Sylvester Cancer Center, and Fellowship Director of the Transplant Infectious Diseases fellowship at the University of Miami/Jackson Memorial Hospital. She has published over 90 peerreviewed articles and 8 book chapters. Dr. Morris has delivered numerous presentations at national and international meetings, including invited lectures on five continents. She is a past president of the Transplantation Society’s Transplant Infectious Disease Section. She is an active member of the American Society of Transplantation’s Infectious Diseases Community of Practice (ID-COP), and a previous executive board member.Acknowledgments: I am privileged to be a member of the international community of transplant infectious disease specialists whose outstanding teamwork is demonstrated in this textbook. An enormous thanks to Camille Kotton and Cameron Wolfe – your dedication and incredible collaboration made this project possible. Thanks also to my daughters Elana and Kayla, who somehow taught me more about life and love (and popular culture) than I could ever teach them. And to my husband, Joel Fishman, who has been there since the beginning, xiii thank you for sharing your life with me. Your unwavering love and support has shaped my growth as a physician and a person. Finally, from all of us in the field of Transplant Infectious Diseases, thank you to our amazing patients for your resilience and optimism and to transplant donors everywhere for making it all possible.Camille Nelson Kotton, M.D., FIDSA, FAST, is Clinical Director of the Transplant Infectious Disease and Immunocompromised Host Program at the Massachusetts General Hospital and Associate Professor of Medicine, Harvard Medical School, Boston, Massachusetts. She was chair of the Infectious Disease Community of Practice of the American Society of Transplantation (2012–2018). From 2007 to 2013, she was the president of the Transplant Infectious Disease Section of The Transplantation Society. Highlights of her time as president include the development of international guidelines on CMV management after solid organ transplant, published in Transplantation (2010, 2013, 2018). She is the first transplant infectious disease specialist to be a councilor of The Transplantation Society (2020). Her clinical interests include cytomegalovirus, donor-derived infections, zoonoses, and travel and tropical medicine in the transplant setting. She would very much like to thank her family for their wonderful support over the years, including her sons Benjamin and David, and her husband Darrell, both for extensive homework projects like this one, and for strength during the COVID-19 pandemicDr. CameronR. Wolfe is an Associate Professor of Medicine in the Division of Infectious Disease at Duke University, specializing in transplant infectious diseases emerging pathogens, HIV, and viral hepatitis. He grew up and trained in Australia, and has research interests in the management of pandemic disease in the general community and especially respiratory viruses in the immunocompromised. He lectures at the University of North Carolina, School of Public Health, as well as the Duke University Medical School. More than anything, Cameron is proud of the grace shown by his two sons, Callum and Lachlan, and his wife, Sarah, as this project has come to fruition!

• Infectious Diseases – impact of infections on transplant morbidity/mortality, data on ID impact on outcomes, and important role of Infectious Disease providers in the transplant team.- Intro to Solid Organ Transplant.- Intro to Stem Cell Transplantation.- General concepts.- Hospital epi / InfControl issues.- Antibiotic Stewardship for transplant ID.- Prophylaxis in the era of emerging new infectious pathogens.- Pre-transplant evaluation of patients with MDRO infection/colonization.- Pre-transplant screening of patients with epidemiologic & geographic risk factors for infection exposure.- Safe living post-transplant.- Vaccination.- Travel medicine and the Transplant Recipient – Infection Avoidance & Management of the Returning Traveler with Fever including Transplant Tourism.- Changing definition of Immunosuppression – Biologics, Monoclonal Antibodies – what infections will emerge as a result and how do we prevent them?.- Multidrug Resistant Organisms including Extended Spectrum Beta Lactamase Producing Organisms & Carbapenemase Resistant Enterobacteriaceae.- Mycobacterium tuberculosis.- Rapidly Growing Nontuberculous Mycobacteria.- Slow Growing Nontuberculous Mycobacteria.- Nocardia.- Mycoplasma / Ureaplasma.- Pseudomonas including Pseudomonas pseudomallei.- Acinetobacter.- Burkholderia.- Clostridia Difficile.- Cytomegalovirus.- Herpes Simplex.- Varicella Zoster.- Epstein Barr Virus including PTLD.- HHV6, HHV7, HHV8.- BK Virus.- Influenza.- Respiratory Syncytial Virus.- Respiratory viruses including parainfluenza, metapneumovirus, rhinovirus, enterovirus, coronaviruses (MERS CoV & SARS).- Adenovirus.- HIV.- Hepatitis A & E.- Hepatitis B & D.- Hepatitis C.- West Nile Virus.- Dengue, Chikungunya, & Zika.- Yellow Fever.- Viral Encephalitides including Rabies & Lymphocytic Choriomeningitis Virus.- Candida.- Aspergillus.- Mucorales.- Non-Aspergillus Molds esp. Phaeohyphomycoses.- Cryptococcus including gatti.- Pneumocystis.- Endemic molds – coccidioidomycosis, histoplasmosis, blastomycosis, paracoccidioidomycosis.- Toxoplasmosis.- Strongyloidiasis.- Chagas disease.- Leishmaniasis.- Malaria.- Entamoeba histolytica.- Intestinal Parasites including Cryptosporidium, Cyclospora, Microsporidia, Blastocystis hominis, Isospora, Giardia.- Acanthamoeba, Naegleria, & Balamuthia.- Ventricular Assist Devices/ECMO/Cardiac Support.- Infection in Vascular Composite Allografts.- Rash.- Eye infections.- Pulmonary.- Diarrhea.- Encephalitis & Delerium.- Cytopenias including Anemia and Neutropenic Fever.

Michele I. Morris, M.D., FACP, FIDSA, FASTProfessor of Clinical MedicineDirector, Immunocompromised Host ServiceDivision of Infectious DiseasesUniversity of Miami Miller School of Medicine1120 N.W. 14th St., Suite 842 (R-21)Miami, FL 33136Camille Nelson Kotton MD, FIDSA, FASTClinical Director, Transplant and Immunocompromised Host Infectious DiseasesInfectious Diseases DivisionMassachusetts General Hospital Harvard Medical School55 Fruit Street, Cox 5Boston, MA 02114 USADr Cameron R.Wolfe MBBS(Hons), MPH, FIDSAAssociate Professor of MedicineTransplant Infectious DiseaseDUMC #102359, Rm 159,Hanes House, Trent DriveDurham, NC, 27710Michele I. Morris, M.D., FIDSA, FAST, is Professor of Clinical Medicine and Director of the Immunocompromised Host Service in the Division of Infectious Diseases at the University of Miami Miller School of Medicine. She has spent the last 17 years of her career focusing her clinical practice and research efforts on transplant infectious diseases, with special attention to the area of emerging infections in transplant. Dr. Morris is also Medical Director of Infection Control and Antimicrobial Stewardship at Sylvester Cancer Center, and Fellowship Director of the Transplant Infectious Diseases fellowship at the University of Miami/Jackson Memorial Hospital. She has published over 90 peerreviewed articles and 8 book chapters. Dr. Morris has delivered numerous presentations at national and international meetings, including invited lectures on five continents. She is a past president of the Transplantation Society’s Transplant Infectious Disease Section. She is an active member of the American Society of Transplantation’s Infectious Diseases Community of Practice (ID-COP), and a previous executive board member.Acknowledgments: I am privileged to be a member of the international community of transplant infectious disease specialists whose outstanding teamwork is demonstrated in this textbook. An enormous thanks to Camille Kotton and Cameron Wolfe – your dedication and incredible collaboration made this project possible. Thanks also to my daughters Elana and Kayla, who somehow taught me more about life and love (and popular culture) than I could ever teach them. And to my husband, Joel Fishman, who has been there since the beginning, xiii thank you for sharing your life with me. Your unwavering love and support has shaped my growth as a physician and a person. Finally, from all of us in the field of Transplant Infectious Diseases, thank you to our amazing patients for your resilience and optimism and to transplant donors everywhere for making it all possible.Camille Nelson Kotton, M.D., FIDSA, FAST, is Clinical Director of the Transplant Infectious Disease and Immunocompromised Host Program at the Massachusetts General Hospital and Associate Professor of Medicine, Harvard Medical School, Boston, Massachusetts. She was chair of the Infectious Disease Community of Practice of the American Society of Transplantation (2012–2018). From 2007 to 2013, she was the president of the Transplant Infectious Disease Section of The Transplantation Society. Highlights of her time as president include the development of international guidelines on CMV management after solid organ transplant, published in Transplantation (2010, 2013, 2018). She is the first transplant infectious disease specialist to be a councilor of The Transplantation Society (2020). Her clinical interests include cytomegalovirus, donor-derived infections, zoonoses, and travel and tropical medicine in the transplant setting. She would very much like to thank her family for their wonderful support over the years, including her sons Benjamin and David, and her husband Darrell, both for extensive homework projects like this one, and for strength during the COVID-19 pandemicDr. CameronR. Wolfe is an Associate Professor of Medicine in the Division of Infectious Disease at Duke University, specializing in transplant infectious diseases emerging pathogens, HIV, and viral hepatitis. He grew up and trained in Australia, and has research interests in the management of pandemic disease in the general community and especially respiratory viruses in the immunocompromised. He lectures at the University of North Carolina, School of Public Health, as well as the Duke University Medical School. More than anything, Cameron is proud of the grace shown by his two sons, Callum and Lachlan, and his wife, Sarah, as this project has come to fruition!

• Infectious Diseases – impact of infections on transplant morbidity/mortality, data on ID impact on outcomes, and important role of Infectious Disease providers in the transplant team.- Intro to Solid Organ Transplant.- Intro to Stem Cell Transplantation.- General concepts.- Hospital epi / InfControl issues.- Antibiotic Stewardship for transplant ID.- Prophylaxis in the era of emerging new infectious pathogens.- Pre-transplant evaluation of patients with MDRO infection/colonization.- Pre-transplant screening of patients with epidemiologic & geographic risk factors for infection exposure.- Safe living post-transplant.- Vaccination.- Travel medicine and the Transplant Recipient – Infection Avoidance & Management of the Returning Traveler with Fever including Transplant Tourism.- Changing definition of Immunosuppression – Biologics, Monoclonal Antibodies – what infections will emerge as a result and how do we prevent them?.- Multidrug Resistant Organisms including Extended Spectrum Beta Lactamase Producing Organisms & Carbapenemase Resistant Enterobacteriaceae.- Mycobacterium tuberculosis.- Rapidly Growing Nontuberculous Mycobacteria.- Slow Growing Nontuberculous Mycobacteria.- Nocardia.- Mycoplasma / Ureaplasma.- Pseudomonas including Pseudomonas pseudomallei.- Acinetobacter.- Burkholderia.- Clostridia Difficile.- Cytomegalovirus.- Herpes Simplex.- Varicella Zoster.- Epstein Barr Virus including PTLD.- HHV6, HHV7, HHV8.- BK Virus.- Influenza.- Respiratory Syncytial Virus.- Respiratory viruses including parainfluenza, metapneumovirus, rhinovirus, enterovirus, coronaviruses (MERS CoV & SARS).- Adenovirus.- HIV.- Hepatitis A & E.- Hepatitis B & D.- Hepatitis C.- West Nile Virus.- Dengue, Chikungunya, & Zika.- Yellow Fever.- Viral Encephalitides including Rabies & Lymphocytic Choriomeningitis Virus.- Candida.- Aspergillus.- Mucorales.- Non-Aspergillus Molds esp. Phaeohyphomycoses.- Cryptococcus including gatti.- Pneumocystis.- Endemic molds – coccidioidomycosis, histoplasmosis, blastomycosis, paracoccidioidomycosis.- Toxoplasmosis.- Strongyloidiasis.- Chagas disease.- Leishmaniasis.- Malaria.- Entamoeba histolytica.- Intestinal Parasites including Cryptosporidium, Cyclospora, Microsporidia, Blastocystis hominis, Isospora, Giardia.- Acanthamoeba, Naegleria, & Balamuthia.- Ventricular Assist Devices/ECMO/Cardiac Support.- Infection in Vascular Composite Allografts.- Rash.- Eye infections.- Pulmonary.- Diarrhea.- Encephalitis & Delerium.- Cytopenias including Anemia and Neutropenic Fever.