Modern Biopharmaceuticals, 4 Volume Set

Dr. Jorg Knablein studied Biotechnology / Chemical Engineering at the Society for Biotechnology Research (GBF) in Braunschweig, Germany and Biochemistry at the Max-Planck-Institute for Biochemistry. He received his Ph.D. from the Max-Planck-Institute for Biochemistry in Martinsried / Munich where he worked in the group of Professor Huber (Nobelprize laureate in 1988). AWARDS:Riedel-de Haen-StiftungGovernment / Ministry of ScienceNomination for the Max-Buchner-Award from DECHEMA (Society for Biotechnology and Chemical Engineering)Winner of the McKinsey business plan contest

"... an authoritative sourcebook dealing with the entire broad range of biopharmaceuticals now available. ... an impressive compilation of outstanding results written by brilliant, creative thinkers who are shaping present and future biotechnology. I am pleased to recommend strongly this complete and comprehensive basic reference source for this new, exciting field to biotechnologists, clinicians, physicians, pharmacists, pharmaceutical chemists, molecular biologists, medicinal chemists, and anyone working in the biotechnological and pharmaceutical industries or in medicinal institutes. It should also be invaluable to undergraduate and graduate students, postdoctoral fellows, and researchers looking for quick, clear, and concise ideas on topics that lie outside their areas of expertise. It also belongs in academic, industrial, and governmental libraries." (The Chemical Educator)"This is an extensive and unmatched compilation of comprehensive, in-depth current knowledge and history of biopharmaceuticals...the author is commended for this grand effort." (Veterinary Pathology)"I heartly recommend this authoritative, comprehensive reference to this new, exciting field dealing with the entire broad range of available biopharmaceuticals. It will be invaluable to biotechnologists, clinicians, physicians, pharmacists, pharmaceutical chemists, molecular biologists, medicinal chemists and anyone working in the biotechnological and pharmaceutical industries or in medicinal institutes. It should be also be useful for undergraduate and graduate students, postdoctoral fellows, and researchers seeking quick, clear, and concise ideas on topics outside their areas of specialization. it should also find a place in academic, industrial, and governmental libraries." (ChemMedChem)"All in all, this is an impressive snapshot of the field." (Journal of Medicinal Chemistry)"... the four volumes represent a highly valuable reference compendium for any practicing scientists interested in this sector of biotechnology." (Chemistry and Industry)"Due to the impressive accumulation of outstanding results, presented by brilliant, privileged and creative thinkers, the book reads like the Who is Who of biotechnology. Never before has such an impressive group of individuals contributed to one biotechnology book, including Nobel Prize laureates Robert Huber, Thomas R. Cech, and Manfred Eigen as well as authors from the world's most famous academic institutes and biotech companies." (BIOforum Europe)

• Volume 1 INTRODUCTIONPART I: BIOPHARMACEUTICALS USED IN MOLECULAR MEDICINEGenes & genomes - correlation between genes, diseases & biopharmaceuticalssiRNA - the magic bullet & other gene therapeutical approachesMobilis in mobile - human embryonic stem cells & other sources for cell therapy Volume 2 PART II: BIOPHARMACEUTICALS AND THEIR MODE OF ACTIONThe clotting cascade - lysis, coagulation & a fine-tuned balanceErrare humanum est - what causes cancer & how to selectively fight tumorsMundus vult decipi - high mutation rates of HIV & new paradigms for treatmentPART III: IMPROVING THE DEVELOPMENT OF BIOPHARMACEUTICALSCitius, altius, fortius - acceleration by high throughput & ultra-HTEarly target validation - knock-out mice & moreRevolution by evolution - rational design for desire & the scientific art of optimization Volume 3 PART IV: PRODUCTION OF BIOPHARMACEUTICALSThe industry's workhorses - mammalian expression systemsA ripe and blooming market - biopharmaceuticals from transgenic animals & plantsAlea non iacta est - improving established expression systemsWhen success raises its ugly head - outsourcing to uncork the capacity bottleneckPART V: BIOPHARMACEUTICALS USED FOR DIAGNOSTICS AND IMAGINGFrom hunter to craftsman - engineering antibodies with nature's universal toolboxFind, fight & follow - target-specific troica from Mother Nature's PharmacopoieaGetting insight - sense the urgency for early diagnostics Volume 4 PART VI: ADVANCED APPLICATION ROUTES FOR BIOPHARMACEUTICALSGetting inside - quest for the best & how to improve deliveryPathfinder - new ways for peptides, proteins & CoVia mala - the stony road of DNA delivery: back-pack, feed-back & pay-backGetting beyond - rocket science & science fictionPART VII: FROM TRANSCRIPTION TO PRESCRIPTIONOpening the therapeutic window - between systemic toxicity & lack of efficacyHappy end - claim to fame & approvalPART VIII: FROM BENCH TO BEDSIDE -THE AFTERMATHSThink big & dealmaking for growth - global changes in the health-care sectorNews & views - quo vadis, biopharmaceuticals?Small molecules - light at the end of the tunnel or back to the roots?