Clinical Pharmacognosy Series – serie

This unique volume presents new understandings of the neurochemical nature of major depression, and how herbs and their constituent flavonoids and terpenes appear to address some of the mechanisms now thought to be involved. It explores how recent studies of the rapid antidepressant effects of ketamine inform neuroscientists about deep intracellular mechanisms of antidepressant action that have little to do with simple enhancement of monoaminergic activity. These mechanisms include actions on PI3K, Akt, mTOR, GSK3, BDNF, and other intracellular pathways. New theories of the pathophysiology underlying major depression, such as oxidative damage, inflammation, stress and insulin resistance are then explored.Key Features:Focuses on oxidative damage, inflammation, and metabolic syndrome. Explains that a significant percentage of people treated for major depression obtain little if any relief from standard antidepressant medications. These facts lead to discussion of herbs that can be used to treat major depression, as well as consideration of the scientific basis for how these herbs act. The antidepressant properties of 66 herbs are discussed, along with dosing and safety information.

The purpose of this book is to focus on major considerations in the clinical use of botanicals as an integrated therapy in current health care. The book uses an organ system approach to presenting clinical evidence on the use of botanicals for common conditions. The chapters include brief sections on background and pharmacognosy, preparation and dosing, safety, evidence and clinical application. In addition, several chapters highlight pharmacokinetic and pharmacogenomic considerations with botanicals in precision medicine and their use in special populations. Finally, a summary on the editors' perspective of "challenges and opportunities" is provided, which discusses the practice of botanicals as integrative therapies and where they are heading in the future.

This unique volume provides the latest information on secondary metabolites obtained from selected organisms (plants or microorganisms) that have beneficial effects in the treatment of cardiovascular diseases and an ability to offer protection against their progress. A detailed description of their source, chemistry and mechanism of action is provided, together with results of clinical studies. Here, a clear connection is made between chemical structures, in vitro studies and their clinical significance.The topic is extensive and the audience gains an understanding of the medicinal applications of these groups of secondary metabolites that have the potential to improve cardiovascular health.Features:The latest information on secondary metabolites with beneficial effects in the treatment of cardiovascular diseases.Written by an outstanding team of authors, their work provides new insights into the beneficial effects of different components present in well known plant products, evidencing their impressive cardiovascular effects.This volume discusses novel targets to screen for new drugs and the need for data obtained from clinical studies using natural products in order to better analyze the significance of in vitro experimental data.Here the reader will find a unique and timely volume with an international flavor.This book describes the source, chemistry and mechanism of action of natural products with the potential to improve cardiovascular health.

This unique volume presents new understandings of the neurochemical nature of major depression, and how herbs and their constituent flavonoids and terpenes appear to address some of the mechanisms now thought to be involved. It explores how recent studies of the rapid antidepressant effects of ketamine inform neuroscientists about deep intracellular mechanisms of antidepressant action that have little to do with simple enhancement of monoaminergic activity. These mechanisms include actions on PI3K, Akt, mTOR, GSK3, BDNF, and other intracellular pathways. New theories of the pathophysiology underlying major depression, such as oxidative damage, inflammation, stress and insulin resistance are then explored.Key Features:Focuses on oxidative damage, inflammation, and metabolic syndrome. Explains that a significant percentage of people treated for major depression obtain little if any relief from standard antidepressant medications. These facts lead to discussion of herbs that can be used to treat major depression, as well as consideration of the scientific basis for how these herbs act. The antidepressant properties of 66 herbs are discussed, along with dosing and safety information.

The deregulation of dietary supplements and natural products marketing by the FDA has widened the natural products market in Europe and worldwide. While the discussion about the validity of the plant approach to nutrition and diseases treatment continues, the explosion of the use of whatever is considered "natural" has generated concern about effectiveness and danger. Incorporating information ranging from regulatory aspects to clinical trial and vigilance, Herbal Medicines: Development and Validation of Plant-Derived Medicines for Human Health: Provides a reference model for those who would like to start the R&D process for a natural product Discusses fundamental issues in the development of traditional medicines for the benefit of human healthTakes a sequential rational approach to the subject matter Brings awareness to the many problems facing the development of medicinal herbal products, such as quality control, pharmacokinetic, and pharmacodynamic issues This book takes readers on a rational path for development of efficacious medicinal herbal products. It points out the many problems facing the development of these products, such as quality control, pharmacokinetic, and pharmacodynamic issues. It suggests areas where future developments should occur given healthcare needs and public health considerations.

Herbal Treatment of Anxiety: Clinical Studies in Western, Chinese and Ayurvedic Traditions explains the nature and types of anxiety, its neurobiology, the pathophysiology that exacerbates and perpetuates it, and the psychopharmacology of the chemical agents that relieve its manifestations. Throughout the text are discussions of Western, Chinese and Ayurvedic herbal treatments that have been clinically shown to be effective in relieving anxiety. The book also features a scientific discussion of the use of herbs and essential oils in aromatherapy and the mechanisms by which they may work. The book concludes by providing bases upon which herbs can be chosen to treat the anxiety of patients according to their individual needs.Additional features include: Examines the increasingly popular subject of the use of herbs as a natural alternative treatment and provides a much-needed scientific basis for treatments often considered as merely "folk medicine." Discusses the psychoactive phytochemicals contained in herbs.Includes a chapter discussing the nature and mechanisms of action of adaptogens.Adds to the armamentarium of anxiolytics for providers who have become reluctant to prescribe benzodiazepines as treatment of anxiety, particularly in the context of the opiate crisis. Gives an introduction to herbal treatments of traditional Chinese and Ayurvedic medicine.Offers practical advice on initiating and managing herbal treatments.Herbal Treatment of Anxiety is a valuable reference for psychiatrists, psychiatric nurse practitioners, primary care providers, naturopathic doctors and therapists interested in the most current scientific information on the effects of herbal treatments of anxiety disorders.

Herbal Treatment of Anxiety: Clinical Studies in Western, Chinese and Ayurvedic Traditions explains the nature and types of anxiety, its neurobiology, the pathophysiology that exacerbates and perpetuates it, and the psychopharmacology of the chemical agents that relieve its manifestations. Throughout the text are discussions of Western, Chinese and Ayurvedic herbal treatments that have been clinically shown to be effective in relieving anxiety. The book also features a scientific discussion of the use of herbs and essential oils in aromatherapy and the mechanisms by which they may work. The book concludes by providing bases upon which herbs can be chosen to treat the anxiety of patients according to their individual needs.Additional features include: Examines the increasingly popular subject of the use of herbs as a natural alternative treatment and provides a much-needed scientific basis for treatments often considered as merely "folk medicine." Discusses the psychoactive phytochemicals contained in herbs.Includes a chapter discussing the nature and mechanisms of action of adaptogens.Adds to the armamentarium of anxiolytics for providers who have become reluctant to prescribe benzodiazepines as treatment of anxiety, particularly in the context of the opiate crisis. Gives an introduction to herbal treatments of traditional Chinese and Ayurvedic medicine.Offers practical advice on initiating and managing herbal treatments.Herbal Treatment of Anxiety is a valuable reference for psychiatrists, psychiatric nurse practitioners, primary care providers, naturopathic doctors and therapists interested in the most current scientific information on the effects of herbal treatments of anxiety disorders.

Recent clinical studies have demonstrated an impact of aromatherapy on the control of symptoms associated with human diseases not fully controlled by conventional therapy. Aromatherapy: Basic Mechanisms and Evidence Based Clinical Use provides an up-to-date compilation of background scientific information that advocates the application of currently developed clinical studies on the effects of aromatherapy to the treatment of human diseases such as mild, stress-induced mood disorders, infectious diseases, and age-related disturbances.The book encompasses all aspects of successful clinical use of aromatherapy, including phytochemistry, technology, and clinical trials. It outlines a rational basis for clinical translation of aromatherapy for treating human diseases in need of safer therapies. It also describes evidence-based use of aromatherapy in controlling clinical manifestations of severe diseases for which conventional therapies often fail, such as managing agitation and aggression associated with Alzheimer�€�s disease and other neurodegenerative diseases.Containing a wealth of references and a thorough presentation of knowledge on essential oils and aromatherapy, this book is a valuable resource for students, researchers, clinicians, and policy makers in health care systems. It details the current clinical uses of aromatherapy while promoting further clinical development in areas where therapy is lacking.

Foods from natural products are a major contributor to contemporary dietary needs. The knowledge of interactions of specific natural products on genes is accumulating due to recent scientific advancements. Natural Products Interactions on Genomes focuses on recent developments in understanding human genome interactions with various natural products.The book first examines selected major natural products and their interactions with selected genes for each chromosome in mammals, then moves on to focused discussions on interactions of natural products with genes that are involved in specific diseases. It includes studies on breast cancer and prostate cancer. The focus then shifts to the effects of natural products on microbial growth and a final chapter that discusses future challenges and prospects in the field.This book also presents a unique real-time approach by providing hyperlinks to websites with updated literature on natural products and interactions with genes involved in metabolic pathways.With a broad range of relevance among disciplines including biology, biomedical science, pharmacy, medicinal chemistry, and naturopathic and herbal medicine, Natural Products Interactions on Genomes provides a valuable reference. It gives you an understanding of the methods of study of natural products and their effects on genomes while pointing toward the future of natural products and the areas they impact in health and science.

The deregulation of dietary supplements and natural products marketing by the FDA has widened the natural products market in Europe and worldwide. While the discussion about the validity of the plant approach to nutrition and diseases treatment continues, the explosion of the use of whatever is considered "natural" has generated concern about effec

Bridging Traditions for a New Era in Personalized Natural Medicine: Volume 1 – Foundations and Mechanisms offers a comprehensive and authoritative exploration of the scientific principles underpinning the integration of natural products into the rapidly evolving field of personalized medicine. By integrating centuries of traditional medicinal knowledge with modern advances in molecular biology, pharmacogenomics, and precision medicine, this volume provides a rigorous evidence-based framework for understanding how natural compounds can be tailored to individual genetic, molecular, and clinical characteristics.The book examines the evolution of personalized medicine, the role of natural products in modern drug discovery, pharmacogenomics, biomarker-guided therapies, and epigenetic regulation, before extending these concepts to precision approaches in oncology, autoimmune diseases, neuropharmacology, autism spectrum disorder, ADHD, and diabetes. Emphasis is placed on translating mechanistic insights into evidence-based therapeutic strategies and demonstrating the clinical potential of plant-derived bioactive compounds in precision healthcare.Written by an international team of experts, each chapter combines current scientific evidence with emerging perspectives to support advanced learning, interdisciplinary research, and clinical innovation. An essential reference for postgraduate students, researchers, clinicians, and academics in pharmacology, pharmaceutical sciences, natural products, and precision medicine, this peer-reviewed volume provides an authoritative foundation for the future development of personalized natural therapeutics.Key Features:Explores the origin, core concepts, and significance of personalized medicine, emphasizing its evolution in modern healthcare.Highlights how natural compounds contribute to drug development and their growing role in integrative, personalized treatment.Examines how genetic variations influence individual responses to natural products, shaping personalized phytotherapy.Discusses biomarkers used to predict, diagnose, and monitor therapy effectiveness when using natural products.Investigates how natural compounds can modulate gene expression without altering DNA, offering targeted treatment options.

Bridging Traditions for a New Era in Personalized Natural Medicine: Volume 1 – Foundations and Mechanisms offers a comprehensive and authoritative exploration of the scientific principles underpinning the integration of natural products into the rapidly evolving field of personalized medicine. By integrating centuries of traditional medicinal knowledge with modern advances in molecular biology, pharmacogenomics, and precision medicine, this volume provides a rigorous evidence-based framework for understanding how natural compounds can be tailored to individual genetic, molecular, and clinical characteristics.The book examines the evolution of personalized medicine, the role of natural products in modern drug discovery, pharmacogenomics, biomarker-guided therapies, and epigenetic regulation, before extending these concepts to precision approaches in oncology, autoimmune diseases, neuropharmacology, autism spectrum disorder, ADHD, and diabetes. Emphasis is placed on translating mechanistic insights into evidence-based therapeutic strategies and demonstrating the clinical potential of plant-derived bioactive compounds in precision healthcare.Written by an international team of experts, each chapter combines current scientific evidence with emerging perspectives to support advanced learning, interdisciplinary research, and clinical innovation. An essential reference for postgraduate students, researchers, clinicians, and academics in pharmacology, pharmaceutical sciences, natural products, and precision medicine, this peer-reviewed volume provides an authoritative foundation for the future development of personalized natural therapeutics.Key Features:Explores the origin, core concepts, and significance of personalized medicine, emphasizing its evolution in modern healthcare.Highlights how natural compounds contribute to drug development and their growing role in integrative, personalized treatment.Examines how genetic variations influence individual responses to natural products, shaping personalized phytotherapy.Discusses biomarkers used to predict, diagnose, and monitor therapy effectiveness when using natural products.Investigates how natural compounds can modulate gene expression without altering DNA, offering targeted treatment options.

The deregulation of dietary supplements and natural products marketing by the FDA has widened the natural products market in Europe and worldwide. While the discussion about the validity of the plant approach to nutrition and diseases treatment continues, the explosion of the use of whatever is considered "natural" has generated concern about effectiveness and danger. Incorporating information ranging from regulatory aspects to clinical trial and vigilance, Herbal Medicines: Development and Validation of Plant-Derived Medicines for Human Health: Provides a reference model for those who would like to start the R&D process for a natural product Discusses fundamental issues in the development of traditional medicines for the benefit of human healthTakes a sequential rational approach to the subject matter Brings awareness to the many problems facing the development of medicinal herbal products, such as quality control, pharmacokinetic, and pharmacodynamic issuesThis book takes readers on a rational path for development of efficacious medicinal herbal products. It points out the many problems facing the development of these products, such as quality control, pharmacokinetic, and pharmacodynamic issues. It suggests areas where future developments should occur given healthcare needs and public health considerations.

The deregulation of dietary supplements and natural products marketing by the FDA has widened the natural products market in Europe and worldwide. While the discussion about the validity of the plant approach to nutrition and diseases treatment continues, the explosion of the use of whatever is considered "natural" has generated concern about effec

Foods from natural products are a major contributor to contemporary dietary needs. The knowledge of interactions of specific natural products on genes is accumulating due to recent scientific advancements. Natural Products Interactions on Genomes focuses on recent developments in understanding human genome interactions with various natural products.The book first examines selected major natural products and their interactions with selected genes for each chromosome in mammals, then moves on to focused discussions on interactions of natural products with genes that are involved in specific diseases. It includes studies on breast cancer and prostate cancer. The focus then shifts to the effects of natural products on microbial growth and a final chapter that discusses future challenges and prospects in the field.This book also presents a unique real-time approach by providing hyperlinks to websites with updated literature on natural products and interactions with genes involved in metabolic pathways.With a broad range of relevance among disciplines including biology, biomedical science, pharmacy, medicinal chemistry, and naturopathic and herbal medicine, Natural Products Interactions on Genomes provides a valuable reference. It gives you an understanding of the methods of study of natural products and their effects on genomes while pointing toward the future of natural products and the areas they impact in health and science.

Recent clinical studies have demonstrated an impact of aromatherapy on the control of symptoms associated with human diseases not fully controlled by conventional therapy. Aromatherapy: Basic Mechanisms and Evidence Based Clinical Use provides an up-to-date compilation of background scientific information that advocates the application of currently developed clinical studies on the effects of aromatherapy to the treatment of human diseases such as mild, stress-induced mood disorders, infectious diseases, and age-related disturbances.The book encompasses all aspects of successful clinical use of aromatherapy, including phytochemistry, technology, and clinical trials. It outlines a rational basis for clinical translation of aromatherapy for treating human diseases in need of safer therapies. It also describes evidence-based use of aromatherapy in controlling clinical manifestations of severe diseases for which conventional therapies often fail, such as managing agitation and aggression associated with Alzheimer’s disease and other neurodegenerative diseases.Containing a wealth of references and a thorough presentation of knowledge on essential oils and aromatherapy, this book is a valuable resource for students, researchers, clinicians, and policy makers in health care systems. It details the current clinical uses of aromatherapy while promoting further clinical development in areas where therapy is lacking.

The purpose of this book is to focus on major considerations in the clinical use of botanicals as an integrated therapy in current health care. The book uses an organ system approach to presenting clinical evidence on the use of botanicals for common conditions. The chapters include brief sections on background and pharmacognosy, preparation and dosing, safety, evidence and clinical application. In addition, several chapters highlight pharmacokinetic and pharmacogenomic considerations with botanicals in precision medicine and their use in special populations. Finally, a summary on the editors' perspective of "challenges and opportunities" is provided, which discusses the practice of botanicals as integrative therapies and where they are heading in the future.