Drug Discovery Opinions – serie

Antimicrobial Therapeutics and Drug Discovery is a comprehensive resource that provides an overview of antimicrobial drug discovery. It covers a wide spectrum of pathogenic organisms causing human infections, exploring alternative therapeutic strategies beyond traditional small molecule drugs. The contents in the book are structured into four parts, each focusing on a different aspect of antimicrobial drug discovery. From exploring viral and host targets, understanding antibiotic resistance mechanisms, to the potential of nanomedicine and computational approaches, the book offers a comprehensive view of the field. Employing a multidisciplinary approach, chapters discuss the importance of drug discovery for fungi, Mycobacteria, Mycoplasma, and parasites, and offers insights into innovative biomedical approaches and combination therapies. By bridging the gap between experimental research and practical application, Antimicrobial Therapeutics and Drug Discovery is a key reference for pharmacologists and pharmaceutical scientists working in academic and corporate research. Medicinal chemists and microbiologists will also benefit from the multidisciplinary coverage of the book.Provides a comprehensive overview of antimicrobial drug discoveryDiscusses ethical imperatives in combating antimicrobial resistanceOffers insights into drug discovery for overlooked pathogensExplores alternative therapeutic strategies for combating antibiotic resistanceBridges the gap between experimental research and practical application

Natural Product Drug Discovery: Highly Anticipated Natural Molecules, a new volume in the Drug Discovery Opinion series, provides a comprehensive examination of the role of natural products in innovative drug development. The book addresses the significant challenges that highly active natural molecules face in the drug development process, including issues related to bioavailability and potency. Sections present analyses of various classes of natural products, including polysaccharides, volatile oils, and diterpenoids, exploring their chemical properties, biological activities, and potential clinical applications. Each chapter, written by leading experts, offers insights into structural modification techniques, naturally sourced inhibitors, and the application of green biomanufacturing strategies.It will serve as an essential resource for researchers, pharmacologists, and industry professionals involved in natural product drug discovery. Readers will find the necessary information to navigate the complexities of the field, emphasizing the integration of traditional knowledge with modern scientific approaches. Through a thorough understanding of these natural compounds, this book aims to contribute to the advancement of therapeutic innovations in pharmacotherapy.Provides a comprehensive analysis of natural products' chemical properties and biological activities for informed drug developmentExplores challenges and solutions in the commercialization of highly active natural moleculesFeatures expert contributions that offer insights into structural modification and green biomanufacturing strategiesIncludes case studies that illustrate successful applications of natural products in therapeutic contextsServes as an essential resource for researchers and professionals in natural product drug discovery and pharmacotherapy

Kinase Targets and Drug Discovery covers the critical role of kinases as regulators of cellular functions and their implications in a range of diseases, from cancers to cardiovascular disorders and inflammatory conditions. Readers will explore foundational concepts on the functions of kinases, the role of kinase inhibitors in disease therapy, and challenges faced. The second section focuses on innovative strategies in kinase drug discovery, covering screening and computational approaches, along with the development of covalent, macrocyclic, allosteric inhibitors, and kinase degraders. Final sections examine clinical applications, detailing how kinase inhibition can be harnessed for cancer therapies, non-oncologic diseases, and even non-catalytic functions.This book will serve as an indispensable resource for pharmacologists, medicinal chemists, and researchers in both academia and industry. By bridging the gap between foundational research and clinical application, it equips professionals with the latest insights and practical approaches to advance their understanding to contribute meaningfully to the evolving landscape of drug discovery.Provides a comprehensive overview of kinase biology and its therapeutic implications across various diseasesExplores innovative strategies for kinase inhibitor discovery and developmentIncludes insights into cutting-edge technologies such as AI and novel therapeutic modalitiesCovers practical approaches for researchers in academia and industry to enhance drug discovery effortsServes as an essential resource for understanding the clinical applications of kinase inhibitors in modern therapeutics

Euphorbiaceae Family Oriented Drug Discovery, a volume in the Drug Discovery Opinions series, aims to comprehensively explore the isolation, identification, synthesis, and drug discovery based on natural products derived from the Euphorbiaceae family. The goals for this editorial project are to consolidate the existing knowledge in this field, fill the gaps in research, and foster further advancements in pharmaceutical science and medicine. The rich diversity and potential pharmacological activities of natural products from this botanic family serves as a springboard for this complete reference. Focused on the isolation, identification, synthesis of bioactive compounds, and drug discovery techniques, the contents of the book are organized into ten chapters. The book opens with an introduction to the Euphorbiaceae family, its botanical overview, medicinal significance, and the importance of exploring its natural products for drug discovery. The next chapters focuses on specific techniques for identification, and synthesis of natural products. Chapter four covers the antitumor activities and mechanisms of action of natural products, followed by a chapter on the specific antimicrobial properties and mechanisms of action. Chapter six discusses anti-inflammatory properties, while chapter seven focuses on pharmacology. Chapter eight is focused on drug discovery processes for Euphorbiaceae Natural Products. The next chapter describe challenges and future directions in research. The final chapter presents the authors final considerations, summarizing the key findings and insights from the book. Euphorbiaceae Family Oriented Drug Discovery helps researchers, students, and practitioners in the fields of pharmaceutical science, pharmacology, medicine, and biotechnology, by providing a comprehensive and up-to-date resource on the natural products of the Euphorbiaceae family. The content cover the latest research findings, methodologies, and technologies used in the isolation, identification, and synthesis of these compounds, as well as their potential applications in drug discovery.Provides a comprehensive overview of the entire process, from isolation and identification to synthesis and drug discovery from the Euphorbiaceae family of plantsCoverage of interdisciplinary areas and scientific disciplines, including botany, chemistry, pharmacology, and biotechnologyOffers insights into future directions and perspectives, highlighting emerging research areas and potential new leads within the Euphorbiaceae family