Engineering and Management Innovation – serie

Thanks to recent advancements, optimization is now recognized as a crucial component in research and decision-making across a number of fields. Through optimization, scientists have made tremendous advances in cancer treatment planning, disease control, and drug development, as well as in sequencing DNA, and identifying protein structures.Optimization in Medicine and Biology provides researchers with a comprehensive, single-source reference that will enable them to apply the very latest optimization techniques to their work. With contributions from pioneering international experts this volume integrates strong foundational theory, good modeling techniques, and efficient and robust algorithms with relevant applications Divided into two sections, the first begins with mathematical programming techniques for medical decision making processes and demonstrates their application to optimizing pediatric vaccine formularies, kidney paired donation, and the cost-effectiveness of HIV programs. It also presents recent advances in cancer treatment planning models and solution algorithms, including three-dimensional conventional conformal radiation therapy (3DCRT), intensity modulated radiation therapy (IMRT), tomotherapy, and proton therapy. Part two focuses on optimization in biology and discusses computational algorithms for genomic analysis; probe design and selection, properties of probes, and various algorithms and software packages to aid in probe selection and design. Subsequent chapters introduce a new dihedral angle measure for protein secondary prediction, and an optimization approach for tumor virotherapy with recombinant measles viruses. The editors include a short tutorial appendix on Integer Programming (IP). Highlighting the most recent advances in optimization techniques for solving complex problems in medical research, this book facilitates strong collaborative environments among optimization researchers and medical professionals for future medical research.

The design of facilities, warehouses, and material-handling systems as well as the management of logistics operations significantly impact the success of industrial projects. Facility Logistics: Approaches and Solutions to Next Generation Challenges explores recent developments in the technology, industrial practices, and business environments of facility logistics.The book first discusses the main trends impacting facility logistics operations, including visibility, security, flexibility, labor, globalization, and sustainability. It then examines the functionalities and capabilities of warehouse management systems (WMS) and outlines a comprehensive yet simple method for the quick assessment of warehouse performance. The following chapters present a set of solutions to emerging challenges in the design and management of facility logistics, along with procedures to better plan and manage the logistics activities within a production or storage facility. The final chapter reviews educational resources and offers examples of how multimedia tools can be used to develop new teaching material.With more globalization and outsourcing occurring as well as a greater emphasis on facility sustainability, new facility logistics challenges have emerged. By evaluating the impact of these issues on facility logistics, this volume helps you improve the design and management of your facility.

Waste, inadequate system performance, cost overruns, and schedule problems often result from failure to apply advanced systems engineering early in project development. Systems engineering is a systematic method to manage the formulation, analysis, and interpretation of what a system will produce and whether the outcome is the one that is desired. This book provides detailed discussions on engineering design and management processes within system lifecycles. The text addresses various issues of systems engineering fundamentals, emphasizing an integrated approach. The author presents methods, frameworks, techniques and tools for designing, implementing, and managing large-scale systems.

As industries adopt consumer-focused product development strategies, they should offer broader product ranges in shorter design times and the processes that can manufacture in arbitrary lot sizes. In addition, they would need to apply state-of-the-art methods and tools to easily conduct early product design and development trade-off analysis among competing objectives. Methods in Product Design: New Strategies in Reengineering supplies insights into the methods and techniques that enable implementing a consumer-focused product design philosophy by integrating design and development capabilities with intelligent computer-based systems. The book defines customer focused design and discusses ways to assess changing demands and sources, and delves into what is needed to successfully manufacture goods in a demanding market. It reviews proven methods for assessing customer need. Then, after showing how changing needs impact the reengineering of products, it explains how change can be efficiently achieved. It details how IT advances and technology support customer-focused product development, discusses cutting-edge mass customization principles that maximize cost-effective production, and illustrates how to implement effective predictive maintenance policies.Methods in Product Design: New Strategies in Reengineering provides methods, state-of-the-art technologies, and new strategies for customer-focused product design and development that allow organizations to quickly respond to the demanding global marketplace.

With coverage that draws from diverse disciplines, Systems Engineering Tools and Methods demonstrates how, using integrated or concurrent engineering methods, you can empower development teams. Copiously illustrated with figures, charts, and graphs, the book offers methods, frameworks, techniques, and tools for designing, implementing, and managing large-scale systems and includes case studies that exhibit the effect of the systems engineering (SE) concept and its importance during the design and development of a complex system. These case studies provide realistic insights into SE methods.Emphasizing the importance of an integrated approach to the design life cycle of complex systems, the book stresses the relationship between SE and project management. It reviews the principles of functional analysis as design activities, discusses verification, validation, and testing (VV& T) methodologies and tools for complex systems, and presents a framework for assessing technology integration at the systems level. It also delineates the development of a business process reengineering plan based on one used for the restructuring, retraining, and redeployment of elements of the Kennedy Space Center workforce.The book includes examples of the design and development of several large complex systems from the DoD and NASA. Each system provides the backdrop for SE learning principles such as technical decision making, requirements definition, logistics support planning, verification, and risk mitigation. Discussions of a proposed integrated reliability management system for faster time-to-market electronics equipment, a new integrative approach to the allocation of adjustability, the importance of manufacturing with regard to designing components of a system, and methods and algorithms used in the solution of combinatorial optimization problems rounds out the coverage.Waste, inadequate system performance, cost overruns, and schedule problems often result from failure to apply advanced systems engineering early in project development. By applying the methods outlined here, you can anticipate and avoid these costly roadblocks when possible, and quickly mitigate their damaging effects when necessary.

As industries adopt consumer-focused product development strategies, they should offer broader product ranges in shorter design times and the processes that can manufacture in arbitrary lot sizes. In addition, they would need to apply state-of-the-art methods and tools to easily conduct early product design and development trade-off analysis among competing objectives. Methods in Product Design: New Strategies in Reengineering supplies insights into the methods and techniques that enable implementing a consumer-focused product design philosophy by integrating design and development capabilities with intelligent computer-based systems. The book defines customer focused design and discusses ways to assess changing demands and sources, and delves into what is needed to successfully manufacture goods in a demanding market. It reviews proven methods for assessing customer need. Then, after showing how changing needs impact the reengineering of products, it explains how change can be efficiently achieved. It details how IT advances and technology support customer-focused product development, discusses cutting-edge mass customization principles that maximize cost-effective production, and illustrates how to implement effective predictive maintenance policies.Methods in Product Design: New Strategies in Reengineering provides methods, state-of-the-art technologies, and new strategies for customer-focused product design and development that allow organizations to quickly respond to the demanding global marketplace.