Ernst Schering Foundation Symposium Proceedings – serie
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114 produkter
Human Gene Therapy: Current Opportunities and Future Trends
Av G. M. Rubanyi, S. Ylä-Herttuala
Inbunden, 2003
2253 kr
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Advances in genetics, molecular biology and gene delivery technologies in recent years have led to new gene therapy strategies for treatment of a variety of diseases. This book gives a comprehensive overview of the present status and future directions of gene delivery systems and therapeutic …
From Morphological Imaging to Molecular Targeting
Implications to Preclinical Development
Av Markus Schwaiger, Ludger Dinkelborg m. fl.
Inbunden, 2004
1692 kr
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Because of the current progress in molecular medicine (genomics, proteomics), a plethora of new and often human-specific targets are being identified. These targets often play a significant role in the pathogenesis of diseases, and identifying them offers the potential for early diagnosis and …
Molecular Imaging
An Essential Tool in Preclinical Research, Diagnostic Imaging, and Therapy
Av A. Bogdanov, Alexei Bogdanov m. fl.
Inbunden, 2004
2253 kr
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The continuous progress in the understanding of molecular processes of disease formation and progression attributes an increasing importance to biomedical molecular imaging methods. The purpose of this workshop was to discuss and overview multiple applications and emerging technologies in the area …
Animal Models of T Cell-Mediated Skin Diseases
Av T. Zollner, Harald Renz m. fl.
Inbunden, 2004
1692 kr
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Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. …
Biocombinatorial Approaches for Drug Finding
Av W. Wohlleben, T. Spellig m. fl.
Inbunden, 2004
1643 kr
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Genome- and proteome-based research is generating a significant increase in the number of available drug targets. Correspondingly there is an increasing need for novel, diverse compounds, particularly based on natural compounds, as screening resource. The purpose of the Ernst Schering Research …
Regenerative and Cell Therapy
Clinical Advances
Av A. Keating, K. Dicke m. fl.
Inbunden, 2004
1098 kr
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This book gives an updated review of the state of the art in regenerative cell therapy in the fields of cardiology, hematology, pediatrics, neurology, orthopedics and infectious diseases. The book emphasizes clinical advances as proof of concept in cell therapy based on the revolutionizing …
New Mechanisms for Tissue-Selective Estrogen-Free Contraception
Av H. B. Croxatto, H.B. Croxatto m. fl.
Inbunden, 2005
1692 kr
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Combined oral contraceptives are the most convenient and accepted method of hormonal contraception. Nevertheless, the medical community and consumers constantly demand innovation, additional benefits during use and lower hormonal load despite the high safety profile of available products. At the …
Promises and Challenges of Regenerative Medicine
Av J. Morser, John Morser m. fl.
Inbunden, 2005
1128 kr
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With the excitement in the research and clinical communities over the potential of regenerative medicine, it is hoped that novel therapies will be developed to target intractable degenerative diseases. In this book, leading experts in the field present the latest advances in stem cell research. It …
Chronic Viral and Inflammatory Cardiomyopathy
Av Schultheiss, H. Schultheiss m. fl.
Inbunden, 2005
1692 kr
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Following its tradition of promoting novel areas of scienti?c discourse, the Ernst Schering Research Foundation (ESRF) hosted this workshop on chronic viral and in?ammatory cardiomyopathy. In late October 2004, scientists from Canada, Germany, the Georgian Republic, Great Britain, Italy, Japan, the …
Von der Wahrnehmung zur Erkenntnis - From Perception to Understanding
Symposium der Schering Forschungsgesellschaft zu Ehren von Prof. Dr. Dr. h.c. Günter Stock, Februar 2004
Av Monika Lessl, Jürgen Mittelstraß
Inbunden, 2005
619 kr
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Der vorliegende Band ist eine Zusammenfassung der Beiträge, die auf einem Symposium mit dem Titel "Von der Wahrnehmung zur Erkenntnis" am 7. Februar 2004 in Berlin stattfand. Anlass war der sechzigste Geburtstag von Professor Dr. Dr. h.c. Günter Stock, Vorstand der Schering AG im Bereich Forschung …
Opportunities and Challenges of the Therapies Targeting CNS Regeneration
Av Perez, H.D. Perez m. fl.
Inbunden, 2005
1128 kr
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The therapeutic options for the treatment of multiple sclerosis (MS) and other neurodegenerative and traumatic diseases such as spinal cord injury, Alzheimer's, Parkinson's disease, etc. , have undergone enormous progress over recent years. Despite these encouraging developments, available …
Histone Code and Beyond
New Approaches to Cancer Therapy
Av Shelley L. Berger, O. Nakanishi m. fl.
Inbunden, 2006
1128 kr
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Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene …
Chemical Genomics
Small Molecule Probes to Study Cellular Function
Av Stefan Jaroch, Hilmar Weinmann
Inbunden, 2006
1692 kr
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Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical …
Appropriate Dose Selection - How to Optimize Clinical Drug Development
Av J. Venitz, W. Sittner
Inbunden, 2006
2188 kr
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Optimal dose individualization has become more important in improving clinical efficacy and safety, given the variability in drug response, e.g., due to concurrent illnesses or co-medications. Therefore, the role of optimal dose finding in early clinical drug development so as to maximize …
Systems Biology
Applications and Perspectives
Av Bringmann, P. Bringmann m. fl.
Inbunden, 2006
1643 kr
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Systems biology has emerged as a highly interdisciplinary ?eld that has created broad enthusiasm in the scienti?c community. Systems biology is in vogue because of its potential to revolutionize not only biology but also medicine. Developments are anticipated that will change how we think about …
Stem Cells in Reproduction and in the Brain
Av John Morser, S. -I. Nishikawa m. fl.
Inbunden, 2006
1098 kr
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Recently, expectations of the potential of regenerative medicine have risen because of the exciting results obtained in various areas of research. This book contains contributions from leading researchers in the field who describe their successes and the problems that remain in converting the hopes …
Biologie und Epidemiologie der Hormonersatztherapie - Biology and Epidemiology of Hormone Replacement Therapy
Diskussionen zur Postmenopausalen Gesundheit - Discussions on Post-Menopausal Health
Av M. A. Lewis, M. Dietel m. fl.
Inbunden, 2006
1128 kr
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Die Vor- und Nachteile der Hormonersatztherapie (HRT) werden von einer Expertengruppe hinsichtlich der epidemiologischen Beweislage diskutiert. Obwohl alle positiven und negativen Aspekte der HRT behandelt werden, liegt der Schwerpunkt der Diskussionen bei der Frage des Brustkrebsrisikos. Unter …
PET Chemistry
The Driving Force in Molecular Imaging
Av P.A. Schubiger, L. Lehmann m. fl.
Inbunden, 2006
2188 kr
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Personalized medicine employing patient-based tailor-made therapeutic drugs is taking over treatment paradigms in a variety of ?elds in oncology and the central nervous system. The success of such therapies is mainly dependent on ef?cacious therapeutic drugs and a selective imaging probe for …
Leucocyte Trafficking
The Role of Fucosyltransferases and Selectins
Av A. Hamann, Khusru Asadullah m. fl.
Inbunden, 2003
1692 kr
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An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in …
Chemokine Roles in Immunoregulation and Disease
Av Philip M. Murphy, Richard Horuk
Inbunden, 2003
1692 kr
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In autumn 2002, the Ernst Schering Research Foundation Workshop sponsored the 45th in its series of conferences devoted to emerging areas in basic and applied biomedical research. These conferences bring together a critical mass of top scientists working in an impor- tant area in an intimate …
New Concepts in Pathology and Treatment of Autoimmune Disorders
Av C. Pozzilli, P. Pozzilli m. fl.
Inbunden, 2001
1128 kr
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Autoimmunity, characterized by autoreactive lymphocytes and autoantibodies, is the consequence of a failure to discriminate between self and non-self, and autoimmune diseases are an increasing threat to people living in the industrialized countries. Autoimmune disorders are treatable, but not …
Neuroinflammation — From Bench to Bedside
Av H. Kettenmann, G. Burton m. fl.
Inbunden, 2002
1128 kr
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Inflammatory processes have been implicated in the pathophysiology of a variety of neurodegenerative diseases such as Alzheimer's disease, stroke and mUltiple sclerosis. It is now widely accepted that the brain, considered to be an "immunologically privileged" organ, can exhibit immune and …
Testicular Tangrams
12th European Workshop on Molecular and Cellular Endocrinology of the Testis
Av F.F.G. Rommerts, K.J. Teerds
Inbunden, 2002
1130 kr
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The book contains the proceedings of the 12th European Testis Workshop and gives an excellent overview of the state of the art in testicular research. The chapters are written by leading scientists in the field of male reproduction, who were selceted on the basis of their specific area of research. …
GPCRs: From Deorphanization to Lead Structure Identification
Av H. Bourne, Richard Horuk m. fl.
Inbunden, 2007
1098 kr
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Based on the international workshop GPCRs: From Deorphanisation to Lead Structure Identification, held in Berlin in May 2006, the book highlights the following topics: Structure of GPCRs, Design of GPCR Ligands, GPCR Signalling, Deorphanization and Assay Development. All chapters are written by …
Tissue-Specific Estrogen Action
Novel Mechanisms, Novel Ligands, Novel Therapies
Av Kenneth S. Korach, Tim Wintermantel
Inbunden, 2007
1692 kr
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Nuclear hormone receptors are not only important drug targets, but have also been the focus of decades of active and highly insightful research. Ten years ago, a review on nuclear receptors was entitled “The Second Decade” and a special issue of Molecular Endocrinology in 2005 dealt with the …
Testis, Epididymis and Technologies in the Year 2000
11th European Workshop on Molecular and Cellular Endocrinology of the Testis
Inbunden, 2000
1692 kr
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A number of chapters present the most novel research on testicular and epididymal functions or on more general fields of hormone action and molecular cell biology as it is now a tradition. However, exceptionally, the book also contains several chapters dealing with the "Approaches and Tools in the …
New Avenues to Efficient Chemical Synthesis
Emerging Technologies
Inbunden, 2007
1098 kr
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In modern drug discovery and development, chemical synthesis is one of the key technologies. For the rapid preparation of new test compounds and drug development candidates, several innovative technologies with great potential have emerged: Microreactor chemistry; Nanotechnology and catalysis …
Immunotherapy in 2020
Visions and Trends for Targeting Inflammatory Disease
Av Andreas Radbruch, Hans-Dieter Volk m. fl.
Inbunden, 2007
569 kr
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This volume features contributions from participants of the ESRF symposium on Immunotherapy in 2020--Visions and Trends for Targeting Inflammatory Diseases held in Potsdam near Berlin, Germany, in October 2006. The symposium presentations covered the main mechanisms of immunoregulation.
Cancer Stem Cells
Novel Concepts and Prospects for Tumor Therapy
Av Otmar D. Wiestler, Bernhard Haendler m. fl.
Inbunden, 2007
2253 kr
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Cancer stem cells werehave originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor, as they divide much more slowly and have very efficient drug- resistance mechanisms. Current treatments might largely spare …
Progestins and the Mammary Gland
From Basic Science to Clinical Applications
Av O. Conneely, Orla M. Conneely m. fl.
Inbunden, 2008
1098 kr
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Progestins play a key role in reproductive endocrinology and as pharmaceutical drugs for contraception and in combined hormone therapy. To further our understanding of progestin action in the mammary gland, an international symposium, attended by leading researchers from academia and industry, was …
