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Immunological Diagnosis of Leukemias and Lymphomas
International Symposium of the Institut für Hämatologie, GSF, October 28–30, 1976 — Neuherberg/Munich
Häftad, Engelska, 1977
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This two-and-a-half-day symposium has concentrated on main aspects of the rapidly expanding field ofleukocyte markers in hematology. While leukemias are already being 'phenotyped' routinely in clinical centers, continued research on the developmental sta ge of cells and cell membranes, expanding into a malignant clone, permits new snap shots on hemopoietic differentiation. Thus the discovery of leukemia-associated anti gens, which so far have not been found on subpopulations of normal cells, has greatly stimulated the discussion on 'differentiation antigens versus tumor antigens'. The proceedings reflect the considerable success which has been achieved very re cently in the classification of hemoblastomas. Consequently the number of leukemias which are unclassifiable by immunological methods have dwindled down to a small mi nority. New facts give rise to new questions. By including the main points of the discussions in the proceedings, we wanted to give the reader an opportunity to get an impression of the questions and conclusions raised and drawn by the participants on the basis of new - and frequently still unpublished - data. The editors thank both the contributors to this symposium, who made it a successful meeting and submitted their manuscripts punctually, and the publishers, who have provided a volume of high quality in good time. They are also grateful for the valuable cooperation from numerous colleages at the Institut fUr Hamatologie.
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Die lahrestagung der Deutschen Gesellschaft fUr Hiimatologie fand im Oktober 1976 nach 21 lahren zum erstenmal wieder in Freiburg statt. 1955 war der KongreBprasident unser unvergessener Ludwig Heitmeyer, der besonders auf dem Gebiete des Eisenstoffwechsels maBgebliche methodische und klinische Pionierarbeit geleistet hat. Die 3 Hauptthemen dieser Tagung sind daher teilweise durch den "genius loci" mitbestimmt (Abb. 1). Abb.1. Ludwig Heilmeyer, 1899-1969 Der Eisenstoffwechsel ist schon seit der Frtihgeschichte ein Problem der Menschheit, dessen Storungen die haufigste Ursache fUr Bluterkrankungen darstellt. Die Phylogenese vom A vertebraten tiber die Vertebraten zum Men- schen ware ohne das Auftreten des eisenhaltigen Hamoglobinmolekiils gar nicht moglich gewesen, schaffte es doch die Voraussetzung der reversiblen Oxygena- tion und damit der zahlreichen Redox-Reaktionen aller einfachen und kompli- zierten Gewebe und Korperorgane. Das so einfach erscheinende Eisenatom kommt in zwei-und dreiwertiger Form vor. Das_zweiwertige Eisen hat an seiner AuBenschale nur 6 d-Elektronen, das dreiwertige Eisen-Ion 5 d-Elektronen.Beide Eisenformen haben gewohnlich eine oktahedrale Koordination, wie aus der Abb. 2 hervorgeht. Vorwort x L, k-_____ -+------::::::==---::~L, L, '"'--=-----+----'~ Abb. 2. Modell des Eisenatoms L, In dieser Form ist das zentrale Metall-Ion umgeben durch vier Liganden-Ato- me LI-L4 an den Ecken des Vierecks und hat auBerdem zwei zusatzliche Liganden-Atome L5 und L6.
Modern Trends in Human Leukemia III
Newest Results in Clinical and Biological Research
Häftad, Engelska, 1979
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"Es ist ja ganz eineriei, wer es gejunden hat, die Hauptsache ist, daB es gejunden worden ist." This was said by Hermann Wilbrand, director of the department of opthalmology at the university hospital Hamburg-Eppendorf (1919-1923), when others claimed priority for the long searched for cortical visuell center, which he had discovered. Five years ago we tried in Wilsede an unusual experiment, bringing together for three long days and nights scientists and medical doctors to learn like students about each others work. The hope was that the participants in the workshop would discuss the whole problem of human leukemia, and coopera- tive programmes among the different specialized research groups and medical centers would be stimulated. Now five years later we feel that the experiment was a success. Coope- rative research programmes around the world were started and most of us understand more and more the Frederic Stohl- man question about the pratical application of our research and its benefit for the patient. The chairman have done a tremendous job organizing an up to date scientific programme for the third Wilsede meet- ing.I would like to thank all of them for a programme which includes all the important results and future aspects of human leukemia.
Adjuvante zytostatische Chemotherapie
Zytostatische Therapie als Rezidivprophylaxe?
Häftad, Tyska, 1978
566 kr
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Das Konzept der experimentellen Onkologie, schon im Stadium der Mikrometa- stasierung zytostatischer Medikamente einzusetzen, wird derzeit bei verschiede- nen menschlichen Tumoren auf breiter Basis untersucht. Damit hat die Frage nach den Erfolgsaussichten und der Indikationsstellung fur adjuvante zytostati- sche Therapie in den letzten Jahren an besonderer Aktualitat gewonnen. Bei einigen Erkrankungen, die dem osteogenen und Ewing-Sarkom, Wilmstumoren, dem embryonalen Rhabdomyosarkom, manchen Hodentumoren u. a., sind Erfolgsaussichten dieses Vorgehens deutlich, bei weit haufigeren Neoplasien, wie dem Mammacarcinom, Ovarialcarcinom, bei malignen Lymphomen u. a., wird die Indikationsstellung lebhaft diskutiert. Die arztliche Entscheidung zu dieser Therapieform wird durch die Diskussion in der bffentlichkeit keineswegs und laBt zusammenfassende, kritische Informationen zu diesem erleichtert Thema besonders suchen.Die gemeinsame Tagung der Deutschen und bsterreichischen Gesellschaft fUr Hamatologie und Onkologie im November 1977 in Linz gab Gelegenheit, die Grundlagen adjuvanter zytostatischer Therapien und den derzeitigen Stand ihrer praktischen Anwendung zu diskutieren, wobei auch Gefahren und Nebenwir- kuilgen breiter Raum gegeben wurde. Urn der Wichtigkeit der Frage gerecht zu werden und die Ergebnisse moglichst auf den letzten Stand zu bringen, konnten fur die Publikation zusatzliche Referenten mit internationalem Ansehen gewonnen werden. Die wichtigsten Diskussionsbemerkungen wurden ebenfalls aufgenommen. Sie mochten dokumentieren, wie viele Fragen noch offen sind und weiterer gemeinsamer Anstrengungen bedurfen. Die Publikation dieses Bandes wurde durch gemeinsame Bemuhungen unserer Mitarbeiter in Linz, St. Gallen und Innsbruck ermoglicht, denen wir besonders verpflichtet sind. Frau Doktor G. Kratzer und Herr Oberarzt Dr. H.
Immunobiology of Bone Marrow Transplantation
International Seminar of the Institut für Hämatologie, GSF, Munich under the auspices of the European Communities March 8–10, 1979, Neuherberg/München
Häftad, Engelska, 1980
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Bone marrow transplantation, the goal which integrates hemato logists, immunologists, geneticists, oncologists and specialists of several other fields, has overcome its state of stagnation in recent years. Clinically as well as experimentally new approaches to old problems and new conclusions from recent findings proliferate: bone marrow transplantation in leukemic remission, bone marrow growth in cell culture, bone marrow manipulation with antisera, bone marrow differentiation in histoincompatible hosts, immuno suppression with partial body irradiation to cite just a few. These and other new developments were discussed by experts from 12 countries in and outside the European Community during an international seminar held on March 8-10, 1979 by the "Institut fur Hamatologie, GSF", under the auspices of the European Communities. The editors thank both the contributors to this symposium, who made it a successful meeting and submitted their manuscripts punctually, and the publishers, who have provided a volume of high quality in good time. They are also grateful for the valuable cooperation from numerous colleagues at the Institut fur Hamato logie.
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Research on aplastic anaemia has until recently been limited to clinical description, morphology and epidemiology. New methods to culture haemopoietic cells, and advances in our knowledge of proliferation and differentiation in the haemopoietic cell system .opened a new area of scientific interest for this "prototype" of haemopoietic failure. In addition, bone marrow transplantation became not only a clinical method of treatment, but also a source of data useful for the discussion of pathophysiological models of aplastic anaemia. This situation prompted us to arrange an international con ference on aplastic anaemia, with particular emphasis on its patho physiology and the rationals of the current therapeutic approaches. This conference was held at Schloss Reisensburg from July 20-22, 1978 with the participation of both experimental and clinical scientists active in this field or in related areas of research. The proceedings of the symposion reflect the present knowledge as well as the many new questions which arose from the discussions. The editors are gratefully indebted to the participants of this meeting, to Gerlinde Trogele and all the co-workers of the Uni versity of Ulm engaged in preparation of this symposium and of this volume, and last not least to all sponsors who provided the financial basis for this scientific event.
Modern Trends in Human Leukemia IV
Latest Results in Clinical and Biological Research Including Pediatric Oncology
Häftad, Engelska, 1981
550 kr
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Gut ist eine Lehrart, wo man vom Bekannten zum Unbekannten fortschreitet; schon ist sie, wenn sie sokratisch ist, d.i. wenn sie dieselben Wahrheiten aus dem Kopf und Herzen des Zuhorers herausfragt. Bei der ersten werden dem Verstand seine Uberzeugungen in Form abgefordert, bei der zweiten sie ihm abgelockt. Professor Friederich Schiller Jena, in a letter written on 23 February 1793 to his friend and supporter Korner, father of the poet Theodor Korner. Established clinicians and scientists as weil as students aga in tried the Wilsede experiment for three days and nights and learned from each other. In our fourth Wilsede meeting on "Modern Trends in Human Leukemia" we concentrated once again on questions re gar ding the practical application of research and its benefits to the patient. The main emphasis of leukemia research has changed since the first Wilsede meeting in 1973. Virology is no longer the sole interest. Advances in immunology and cell genetics and a better understanding of Dr. h. c.Alfred Toepfer speeking with participants of the meeting in Wilsede XXI Arrival and discussion of participants in front of the meeting pI ace "De Emmenhoff" XXII Personal and scientific discussion in Wilsede June 1980 Fotos: R. Vols XXIII the mechanisms regulating normal and pathological blood cell differen- tiation have had a considerable impact on the direction of leukemia research.
Del 27 - Haematology and Blood Transfusion Hämatologie und Bluttransfusion
Disorders of the Monocyte Macrophage System
Pathophysiological and Clinical Aspects
Häftad, Engelska, 1981
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The origin and function of normal monocytes and macrophages have been clearly defined by extensive investigations in human and in animal models. The central importance ofthis cell system for the biological defense mecha- nisms is well established: phagocytosis, inactivation and destruction of organic and inorganic materials, an important role in the initiation ofhumo- ral and cell mediated immunological responses, and the secretion of a varie- ty of chemical mediator and effector substances are the most important fea- tures of this ontogenetically ancient cell system. However, the data on this cellular system are rather recent, and this may explain why relatively little attention has been payed to the pathology of the monocyte-macrophage system (MMS) until now. In addition, this monograph should focus attention on the secondarypa- thophysiological implications of the MMS in disorders not primarily origi- nating from this system. Several techniques are available to identify even abnormal individuals of this cell system and, therefore, can be employed for the study of severely altered or neoplastic monocytic cells.
Modern Trends in Human Leukemia V
New Results in Clinical and Biological Research Including Pediatric Oncology
Häftad, Engelska, 1983
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Levy, 10 Po: General Summary of the Meeting 507 Subject Index 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 515 1 Also special Lecture for the Wilsede Joint Meeting on Pediatric Oncolo- gy II 2 Were also presented in the Wilsede Joint Meeting on Pediatric Oncology II 3 Presented in the Wilsede Joint Meeting on Pediatric Oncology II xv Participants of the Meeting Anders, Fritz, Genetisches Institut der Universitaet, Heinrich-ButT-Ring 58-62,6300 Giessen, Federal Republic of Germany Bauer, Georg, Institut fuer Virologie im Zentrum fUr Hygiene, Hermann- Herder-Strasse 11,7800 Freiburg, Federal Republic of Germany Bell, Richard, Medical Oncology University Hospital, 75 East Newton Street, Boston, MA 02062, USA Bernhard, Silke, Dahlem-Konferenzen, Wallotstrasse 19, 1000 Berlin 33, Federal Republic of Germany Bister, Klaus, Max-Planck-Institut fUr Molekulare Genetik, Ihnestrasse 63-73, 1000 Berlin 33, Federal Republic of Germany Blattner, William A. , Family Studies Section, Environmental Epidemiology Branch, National Cancer Institute, Landow Building, Rm.4C18, 7910 Woodmont Avenue, Bethesda, MD 20205, USA Boiron, Michel, Institut de Recherches sur les Leucemies et les Maladies du Sang, Universite Paris VII, Hopital Saint-Louis, 2 Place du Docteur-Four- nier, 75475 Paris Cedex 10, France Boniver, Jacques, Institut de Pathologie B 23, Laboratoire d'Anatomie, Pathologique, 4000 Liege, Belgium Bornkamm, Georg W. , Institut fuer Virologie im Zentrum fuer Hygiene, Hermann-Herder-Strasse 11,7800 Freiburg, Federal Republic of Germany Burgess, Antony W.
Modern Trends in Human Leukemia VI
New Results in Clinical and Biological Research Including Pediatric Oncology
Häftad, Engelska, 1985
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In June 1984 a total of 169 physicians, scientists and students assembled in the now familiar and much-loved lair in the Wilsede Luneberg Heath near Hamburg, Germany, for the sixth biennial conference on Modern Trends in Human Leukaemia. This meeting, conducted by Prof. Rolf Neth in his own inimitable style, has established itself as one ofthe major events in the all too crowded programme of international conferences on leukaemia, cancer and related topics. Some may ponder why, with its "rustic" setting - flies, equine deposits, and lack of easy exit -, Wilsede has such an irresistible and persistent lure for so many of the world's top practitioners ofleukaemia research? The an- swer is, I suspect, a cocktail of Rolfs extraordinary charm, the pleasure of meeting friends and colleagues in a uniquely informal and relaxed atmo- sphere and the special style of the proceedings themselves, which focus on the evaluation of ideas and hypotheses rather than the cataloguing of data.
Modern Trends in Human Leukemia VII
New Results in Clinical and Biological Research Including Pediatric Oncology
Häftad, Engelska, 1987
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Ideo autem omnes ad consilium vocari diximus, quia saepe iuniori Dominus revelat quod melius est. * Benedictus de Nursia Regula Benedicti, ca. 550 A. c. Caput III,3 The Wilsede Meetings were initiated in 1973 as an unusual experiment, and in the meantime this biennial symposium has already come to constitute an established and successful tradition. In June 1986 scientists and physicians met for the seventh time in the 3- year-old Emmenhof in Wilsede, in the heart of the Liineburg Heath, to dis- cuss modern trends in human leukemia. It was Pappenheim who in 1910 prepared the first international hematol- ogy congress. It was to have been held in Berlin under the title "Der groBe mononukleiire Leukozyt Ehrlichs, seine Morphologie und Funktion, seine Herkunft und seine Benennung" (Ehrlich's large mononuclear leukocyte. Its morphology, function, origin, and name), which was the most important and topical question at that time. It is amazing to think that as early as 1900, thanks to the pioneering research of Maximov and the innovative staining method developed by Ehrlich, the differentiation of the blood cells had, to a large extent, already been discovered.It is a sad fact that this congress never took place due to personal controversies among leading hematol- ogists, especially between Pappenheim and the Austrian hematologist Tiirk. Fortunately the Wilsede Meetings have never incurred this type of per- sonal controversies. On the contrary, both matter-of-fact discussions at a high scientific level and the development of personal friendships have always characterized their singular atmosphere.
Modern Trends in Human Leukemia VIII
New Results in Clinical and Biological Research Including Pediatric Oncology
Häftad, Engelska, 1989
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You see things, and sa)' why? But I dream 1hings that never were, and I say, 11'hy 110t? George Bernhard Shaw Far ahead of his time, June 1st, 1909, Alexander Maximov communicated in a lecture, given in the Charite in Berlin, the fundamental knowledge, that there exists a lymphoid hemopoetic stem cell. Alexander Friedenstein explained that during the following years, Maximov also showed that the idea of interaction between hemopoetic cells and their stroma to be one of the most significant experiences. Monoclonal antibodies, recombinant DNA technics and the improvement of tissue culture models are the major developments to improve our possibilities to clarify growth and differentiation functions of hemopoetic cells. During the last two decades it was shown that soluble products, released from T cells, were not only involved in inducing B cells to produce specific immunoglobulin secretion after antigen stimulation. Furthermore, lymphokines together with other cytokines regulate the growth and differentiation of hemopoetic cells. As I have learned from Dick Gershon, our knowledge of the cellular basis for immunoregulation has come a long way since 450 B.C. Thucydides comments on the possible role of immune response in controlling the Black Death. Dick Gershon speculated that no scientific interest for these interesting observations was put forth at that time. Perhaps the problems, the Athenians were having with the Spartans, converted money from basis research into the military budget.
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Acute leukemia a quite homogenous disease failed to break through the sound barriere of when untreated reveals a substantial hetero unsatisfactory cure rates even in special sub geneity in its response to therapy. While cure groups. While new protocols including more is achieved in a certain proportion of pa effective supportive care show some increase tients other cases prove to be highly resis in the initial response rates and certain im tant. The curability is superior in acute provements in the long-term results, no ben lymphoblastic (ALL) than in acute myeloid eficial effect on the relapse rate during the (AML) leukemia and - within both type- first 1 Y2 years emerged from any of these higher in children as compared to adults. regimens. Thus, high chances for cure are The two age groups and cell types can be presently restricted to children with ALL further subdivided into prognostic groups and to lesser proportions children with by special diagnostic features. Thus, in AML and adults with ALL and AML.
Acute Leukemias
Pharmacokinetics and Management of Relapsed and Refractory Disease
Häftad, Engelska, 1992
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Following the major breakthroughs in the and frequent and thorough exchange of treatment of acute leukemias in the seven- information. Hence, it was felt that a spe- ties by the introduction of intensive combi- cial series of symposia should be devoted to nation regimens, therapeutic progress has "Pharmacokinetics and Management of slowed down and the impression of stagna- Relapsed and Refractory Disease" comple- menting the established meetings on "Prog- tion may even have occured. In contrast, the knowledge about the biology of leu- nostic Factors and Treatment Strategies" kemias is rapidly expanding and allows new which will proceed in parallel. It was the insights into the pathophysiology of the aim of the international symposium disease. Further improvements also come "ACUTE LEUKEMIAS - Pharmacokine- from a better understanding of the pharma- tics and Management of Relapsed and cokinetics and pharmacodynamics of cyto- Refractory Disease" to provide an update static drugs and their mechanisms of action. of the present knowledge in this area and to Hence, novel treatment modalities can be stimulate further developments.As a sign developed on a more solid basis and ration- for the closing distance between countries al. These achievements need to be comple- and the development of effective world- mented by effective eradiation wide cooperation this symposium emerged of residual disease or its permanent control and new from the joint efforts of the German AML approaches have been derived from recent Cooperative Group and the M. D.
Modern Trends in Human Leukemia IX
New Results in Clinical and Biological Research Including Pediatric Oncology
Häftad, Engelska, 1992
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The most recent trends in human leukemia, which were discussed at the Ninth Wilsede Meeting, are presented in this volume. The internationally renowned contributors discuss both clinical aspects as well as biomedical studies. They present new information about the biological basis of leukemia which has been gained using the methods of molecular genetics, cell and molecular biology, virology and immunology. The evidence clearly shows both the complexity of leukemia research, as well as the value of basic scientific research in furthering clinical medicine and therapy.
Knochenmark-Insuffizienz
Berichtsband des Deutsch-Österreichischen Kongresses für Hämatologie 21. – 23. März 1974 in Wien
Häftad, Tyska, 1982
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Modern Trends in Human Leukemia II
Biological, Immunological, Therapeutical and Virological Aspects
Häftad, Engelska, 1983
550 kr
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mene Stil in jeglicher Kunst, daft er die spezijischen Schranken derselben zu entfernen weip, ohne doch ihre spezijischen Vorzuge mit aufzuhe- ben, und durch eine weise Benut- zung ihrer Eigentumlichkeit ihr einen mehr allgemeinen Charakter erteilt. Friedrich Schiller - Ober die as the- tische Erziehung des Menschen. In den Horen, 22. Brief (1795) We are glad that you have all come to this small village and I hope that you will feel at home here for the next few days. The special atmosphere of the surround- ings will probably have a good influence on our discussions, and you will perhaps remember this when you are back home again. It takes hard work to save this little piece of nature for man in our highly industrialized world, and we should all be grateful to the Verein Naturschutzpark e. V. (founded in 1909), Alfred Toepfer and his associates for their efforts. We intend to discuss modern trends in human leukemia in this workshop, but we should also take the opportunity to reflect on the trends of the past, which might still be modern.
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Since 1987 Acute Leukemias (AL) has regularly reported on the state of the art in the rapidly growing, successful and exciting field of biology and management of these diseases. In this volume large multicenter clinical trials again form the solid basis for the investigation of leukemic cell biology, the detection of biologic subgroups, their differential response to alternative treatment strategies and the further development of therapy. In particular, this volume addresses mechanisms of chromosomal translocations and transcription factors, risk-adapted treatment strategies, differentiation therapy, secondary AL, special aspects in older patients, and adoptive immunotherapy. Besides the antileukemic approaches, supportive treatment with new antimicrobial substances and growth factors is updated. As a forum of worldwide activities in the field of AL this volume contains both exhaustive overviews on major clinical issues and preliminary data and hypotheses not previously published.
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The 6th volume of the book series Acute Leukemias presents both therapeutic and prognostic updates of the most recent results of major multicenter clinical trials. Additional chapters report on new trends in leucemia cell biology, the monitoring of minimal residual disease and secondary leucemias as well as new antileucemic drugs, antimicrobial strategies and the use of cytocines. Acute Leukemias VI provides a new update on the rapid progress being made internationally concerning leucemic diseases.
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Evaluation of molecular and immunologic leukemia cell markers has provided a better understanding of residual leukemia in clinical remission, as a prognostic factor and in monitoring the effectiveness of the antileukemic strategy.
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150 years after the first description of the clinical picture of "white blood" and the introduction of the term "leukemia" by R. Virchow it appears, that the leukemias, and the acute leukemias in particular, serve as an impressive example for the major improvements that have been achieved in the treatment but also in the understand ing of the biology of malignant dis orders. The international symposia "Acute Leukemia" which are held at Münster since 1986 have developed into an interna tional forum to review the current progress and the future perspectives of leukemia research and therapy at a high scientific and clinicallevel. Since the possibility for active participation in these symposia is somewhat restricted we are glad to have the opportunity to extend the information that was presented at the symposium "Acute Leukemias V - Experimental Approaches and Management of Refractory Disease" which was held from February 27 to March 2, 1994 to a broader audience of basic scientists and clinicians. This meeting was especiaIly designed to discuss experimen tal approaches and the management of refractory disease which allows to evaluate new experimental therapies on the basis of preclinical studies.