IOS Press – serie

A general trend in our modern society is a growing complexity. It is therefore logical that in most countries there has been a definite tendency to give weight to issues of adapting also the physical space to this complexity and to find methods to do this in an efficient way, giving satisfactory use of land and other natural resources. During the twentieth century we have seen a very active development of legal instruments for this purpose, aimed at steering spatial planning and plan implementation according to the objectives and policies chosen.This book tries to present basic information of how different countries within the chosen area have tried to solve the problem of establishing suitable systems of steering spatial development by means of planning and implementation measures. For this purpose summary descriptions of the connected formal regulations in each country are given in an appendix while a comparative presentation and discussion forms the main text. This will give the interested reader an overview of the current systems in Western Europe, how they have influenced each other but still in many parts differ from each other.

The origin of Aerodynamic Design of Transport Aircraft stems from the time when the author was appointed part-time professor in the Aerospace Faculty of Delft University of Technology. At the time his main activities were those of leading the departments of Aerodynamics, Performance and Preliminary Design at Fokker Aircraft Company. The groundwork for this book started in 1987 as a series of lecture notes consisting mainly of pictorial material with a minimum of English explanatory text. After the demise of Fokker in 1996 one feared that interest in aeronautical engineering would strongly diminish. As a result of this, the course was discontinued and the relationship between the author and the faculty came to an end. Two years later the situation was reappraised, and the interest in aeronautical engineering remained, so the course was reinstated with a former Fokker colleague Ronald Slingerland as lecturer. The lecture notes from these courses form the foundation of this publication.

In the summer of 1982, hospital emergency rooms in the San Francisco Bay Area were suddenly confronted with mysteriously “frozen” patients – young men and women who, though conscious, could neither move nor speak. Doctors were baffled, until neurologist J. William Langston, recognizing the symptoms of advanced Parkinson’s disease, administered L-dopa – the only known effective treatment – and “unfroze” his patient. Dr. Langston determined that this patient and five others had all used the same tainted batch of synthetic heroin, inadvertently laced with a toxin that had destroyed an area of their brains essential to normal movement. This same area, the substantia nigra, slowly deteriorates in Parkinson’s disease. As scientists raced to capitalize on this breakthrough, Dr. Langston struggled to salvage the lives of his frozen patients, for whom L-dopa provided only short-term relief. The solution he found lay in the most daring area of research: fetal-tissue transplants. The astonishing recovery of two of his patients garnered worldwide press coverage, helped overturn federal restrictions on fetal-tissue research, and offered hope to millions suffering from Parkinson’s, Alzheimer’s, and other degenerative brain disorders. This is the story behind the headline – a spellbinding account that brings to life the intellectual excitement, ethical dilemmas, and fierce competitiveness of medical research. This new updated edition of the classic neurological mystery tale, “The Case of the Frozen Addicts,” illuminates how the solution to a baffling mystery of the brain’s chemistry opened a new frontier in medicine and restored life to people without hope. “It begins with a series of quixotic discoveries, escalates to providing possible solutions for one of humanity’s most intractable medical problems, and then catapults the reader into the center of America’s hottest political arena – abortion and fetal sanctity. Bravo! A brilliant read.” – Laurie Garrett, author of The Coming Plague “[Langston and Palfreman] weave a highly readable and spellbinding medical detective tale… It is as absorbing as a good mystery, as entertaining as an exciting novel, and as enlightening as a good biography.” – Stanley Fahn, New England Journal of Medicine “I could not put it down… it is the lives of the ‘frozen addicts’ themselves – and the fullness with which this is presented – which makes the whole thing overwhelming.” – Oliver Sacks