Laboratory Animal Pocket Reference – serie

With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. Revised to reflect advances since the second edition, The Laboratory Mouse continues to be the most accessible reference on the biology and care of the mouse in research settings. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers on the humane care and use of the mouse. The new edition adds information on novel technologies such as CRISPR-Cas and on housing systems and management practices; it covers new concepts such as pain assessment by facial expression and the importance of nest-building as an assessment tool of well-being. There are now expanded sections on anesthesia and analgesia, and on behavior and enrichment.An ideal quick reference for investigators, technicians, and animal caretakers charged with the care and/or use of mice in a research setting, this book will be particularly valuable to those new to working with mice who need to start research programs using these animals.

This guide covers all aspects pertaining to the use of zebrafish including their basic biology, humane care and management, husbandry, life support systems, regulatory compliance, technical procedures, veterinary care, and water quality management. The zebrafish is now a mainstream model animal employed by scientists to study everything from stem cells to the basis of behavioral changes induced by drug addiction. However, there are few accepted and established standards for husbandry, management, and care for the fish in laboratory settings and even fewer comprehensive and constantly reliable resources. To this end, the goal of this handbook is to provide managers, veterinarians, investigators, technicians, and regulatory personnel with a concise yet thorough reference on zebrafish biology, care, husbandry, and management. The new edition includes more figures, tables and bullet points, a wealth of new full-color images, major updates on health and welfare (including colony health surveillance and viruses), and a complete overhaul of the compliance section to address more international concerns.

This guide covers all aspects pertaining to the use of zebrafish including their basic biology, humane care and management, husbandry, life support systems, regulatory compliance, technical procedures, veterinary care, and water quality management. The zebrafish is now a mainstream model animal employed by scientists to study everything from stem cells to the basis of behavioral changes induced by drug addiction. However, there are few accepted and established standards for husbandry, management, and care for the fish in laboratory settings and even fewer comprehensive and constantly reliable resources. To this end, the goal of this handbook is to provide managers, veterinarians, investigators, technicians, and regulatory personnel with a concise yet thorough reference on zebrafish biology, care, husbandry, and management. The new edition includes more figures, tables and bullet points, a wealth of new full-color images, major updates on health and welfare (including colony health surveillance and viruses), and a complete overhaul of the compliance section to address more international concerns.

For critical care of laboratory rodents, there is a scarcity of sources for comprehensive, feasible, and response-oriented information on clinical interventions specific to spontaneous and induced models of disease. With the more complex cases that need critical care management, many treatment approaches to veterinary emergencies cannot be applied directly to the laboratory rodent. The first text of its kind devoted to the challenges of critical care management for laboratory rodents, Critical Care Management for Laboratory Mice and Rats provides a specialized resource for all veterinary, husbandry, technical, and research professionals who utilize rodent models for biomedical research.The book covers the varied approaches to laboratory rodent patient care, health assessments, characteristics of specific disease models, monitoring and scoring of disease parameters, and humane interventions. Giving primary consideration to preservation of animal health and welfare, the text also considers how best to balance welfare with the achievement of proposed scientific objectives. Organized into five chapters, this full-color book covers the following topics: General Approaches for Critical CareCritical Care Management for Laboratory MiceCritical Care Management for Laboratory RatsSpecial Considerations for Critical Care Management in Laboratory RodentsResources and Additional InformationThe author provides treatment guidelines with the expectation that they will be applied with apt professional judgment, allowing for further modification of clinical recommendations for improved patient-based care and welfare for research animals.

This guide was created especially for individuals performing research with cats whose duties include animal facility management, animal husbandry, regulatory compliance, and technical procedures involved with their research. Basic information and common procedures are presented in detail.

The Laboratory Small Ruminant details basic information and common procedures for individuals performing research with small ruminants. Details include duties of animal husbandry, regulatory compliance, and technical procedures. It is designed to assist in the humane care and use of small ruminants in the laboratory and to provide immediate information for investigators, technicians, and animal caretakers. It includes references to alternative procedures and methods and offers possible sources and suppliers of animals, feed, sanitation supplies, cages, and research and veterinary supplies. Researchers, investigators, lab technicians and animal caretakers will need this resource.

Laboratory animals, including dogs, play an important role in biomedical research and medical advances. Dogs have a long history of use in research and have contributed enormously to the health and welfare of both humans and animals. The humane care and management of these animals is a fundamental component of their use in medical research.The Laboratory Canine clearly presents basic background information covering subjects that apply specifically to dogs used in research settings, such as basic biological features, husbandry, management, veterinary care, experimental methodology, and resources. The book offers guidance on performing a detailed physical examination, including necessary veterinary supplies, clinical signs of illness, clinical conditions, and reference tables of widely used veterinary drugs. It discusses the human-animal bond or the relationship between people and animals and its significance and importance to the quality of research, the health of the animals, and the emotional health of staff caring for or working with animals. It also examines anesthetic and surgical procedures that include pre-, intra-, and post-anesthesia/operative monitoring. The Laboratory Canine contains reference charts for monitoring patients through post-operative recovery and reference tables for anesthetics and analgesics. Because dogs are a highly visible species in the eyes of the public and regulators, it is important that individuals working with laboratory canines have the proper training and experience. This valuable resource is ideal for those charged with the care and use of canines in a research setting.

Since the popular second edition of The Laboratory Swine was published more than a decade ago, the number of pigs used in toxicity studies has increased as an alternative to commonly used non-rodent species, while, at the same time, large developments have been made in welfare concepts of laboratory animals. Pigs have gained prominence in both basic and applied research, leading to a significant increase in publication activity.This third edition summarizes these new insights, raising the bar for humane care and use of pigs, from agricultural sources to genetically and microbiological defined minipigs. Aimed at animal caretakers, technicians, laboratory animal veterinarians, and investigators planning and performing studies on pigs, it provides an overview with extensive references for further study. The book has been updated with a special focus on refined methods for housing and handling pigs, including an updated description of commonly performed experimental and surgical procedures.Continuing its legacy as the premier reference on the care and use of pigs in the laboratory, the small, practical, and accessible format makes this an easy "go-to" book, with easy-to-find information and high-quality color images. The third edition aims to contribute to humane use and care for laboratory pigs in all aspects of housing, husbandry, veterinary care, and experimental techniques.

Since the popular second edition of The Laboratory Swine was published more than a decade ago, the number of pigs used in toxicity studies has increased as an alternative to commonly used non-rodent species, while, at the same time, large developments have been made in welfare concepts of laboratory animals. Pigs have gained prominence in both basic and applied research, leading to a significant increase in publication activity.This third edition summarizes these new insights, raising the bar for humane care and use of pigs, from agricultural sources to genetically and microbiological defined minipigs. Aimed at animal caretakers, technicians, laboratory animal veterinarians, and investigators planning and performing studies on pigs, it provides an overview with extensive references for further study. The book has been updated with a special focus on refined methods for housing and handling pigs, including an updated description of commonly performed experimental and surgical procedures.Continuing its legacy as the premier reference on the care and use of pigs in the laboratory, the small, practical, and accessible format makes this an easy "go-to" book, with easy-to-find information and high-quality color images. The third edition aims to contribute to humane use and care for laboratory pigs in all aspects of housing, husbandry, veterinary care, and experimental techniques.

With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. Revised to reflect advances since the second edition, The Laboratory Mouse continues to be the most accessible reference on the biology and care of the mouse in research settings. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers on the humane care and use of the mouse. The new edition adds information on novel technologies such as CRISPR-Cas and on housing systems and management practices; it covers new concepts such as pain assessment by facial expression and the importance of nest-building as an assessment tool of well-being. There are now expanded sections on anesthesia and analgesia, and on behavior and enrichment.An ideal quick reference for investigators, technicians, and animal caretakers charged with the care and/or use of mice in a research setting, this book will be particularly valuable to those new to working with mice who need to start research programs using these animals.

Rats have long been recognized as a valuable biomedical research model, notably in the investigation of aging, toxicology, addiction, and common human diseases such as diabetes and hypertension. In many instances, individuals conducting such research studies are charged with important responsibilities, including animal facility management, animal h

Laboratory animals, including birds, play an important role in biomedical research. The humane care and management of these animals is an ongoing concern. A new addition to the acclaimed Laboratory Animal Pocket Reference series, The Laboratory Bird is the first publication dedicated to the care and use of avian species in the research setting. Covering avian species such as chickens, ducks, doves, parrots, and songbirds that are commonly used as research models, the book is divided into focused chapters that cover a broad range of topics, including:General avian biology and physiology Husbandry Regulations and regulatory compliance regarding the use of birds in research Experimental methods Veterinary care Along with discussing applicable regulations, the book also details issues of health management and quarantine approaches. The final chapter provides resources such as organizations, publications, vendors, and diagnostic laboratories. With its focus on the care of a diverse group of avian species in biomedical research settings, The Laboratory Bird is a valuable reference for animal care and veterinary technicians, laboratory animal veterinarians, trainees in laboratory animal medicine, and research staff members, as well as individuals involved in laboratory work who lack experience in working with birds.

Laboratory animals, including ferrets, play an important role in biomedical research and advances. The humane care and management of these animals remains an ongoing concern. Published in color to provide greater clarity to the techniques and concepts discussed, The Laboratory Ferret presents basic information and common procedures in detail to provide a quick reference for investigators, technicians, and caretakers in the laboratory setting. The book presents a greater understanding of the use of the ferret in research, such as in studies on influenza. It is a valuable, handy reference for experienced individuals and for those without extensive training in working with ferrets.

Rats have long been recognized as a valuable biomedical research model, notably in the investigation of aging, toxicology, addiction, and common human diseases such as diabetes and hypertension. In many instances, individuals conducting such research studies are charged with important responsibilities, including animal facility management, animal husbandry, veterinary care, regulatory compliance, and various experimental methodologies. With the advent of genetic manipulations and biomedical research technological advances such as bioimaging, the versatility and usefulness of the rat as an animal model has soared. The Laboratory Rat, Second Edition captures the multiple advances in this important animal model‘s husbandry, veterinary care, and experimental methodology. This edition features augmented, expanded, and novel information on biology, anesthesia, analgesia, and experimental techniques benefiting personnel working with rats from the animal care staff to the researcher and everyone in between. The book is also extremely useful to institutional animal care and use program supporters and elements, including animal care and use committees, institutional officials, occupational health and safety professionals, veterinary technicians, and veterinarians.

For critical care of laboratory rodents, there is a scarcity of sources for comprehensive, feasible, and response-oriented information on clinical interventions specific to spontaneous and induced models of disease. With the more complex cases that need critical care management, many treatment approaches to veterinary emergencies cannot be applied directly to the laboratory rodent. The first text of its kind devoted to the challenges of critical care management for laboratory rodents, Critical Care Management for Laboratory Mice and Rats provides a specialized resource for all veterinary, husbandry, technical, and research professionals who utilize rodent models for biomedical research.The book covers the varied approaches to laboratory rodent patient care, health assessments, characteristics of specific disease models, monitoring and scoring of disease parameters, and humane interventions. Giving primary consideration to preservation of animal health and welfare, the text also considers how best to balance welfare with the achievement of proposed scientific objectives. Organized into five chapters, this full-color book covers the following topics:General Approaches for Critical Care Critical Care Management for Laboratory Mice Critical Care Management for Laboratory Rats Special Considerations for Critical Care Management in Laboratory Rodents Resources and Additional InformationThe author provides treatment guidelines with the expectation that they will be applied with apt professional judgment, allowing for further modification of clinical recommendations for improved patient-based care and welfare for research animals.

The Laboratory Small Ruminant details basic information and common procedures for individuals performing research with small ruminants. Details include duties of animal husbandry, regulatory compliance, and technical procedures. It is designed to assist in the humane care and use of small ruminants in the laboratory and to provide immediate information for investigators, technicians, and animal caretakers. It includes references to alternative procedures and methods and offers possible sources and suppliers of animals, feed, sanitation supplies, cages, and research and veterinary supplies. Researchers, investigators, lab technicians and animal caretakers will need this resource.

Even though Xenopus is one of the two most popular non-mammalian animals used in biomedical research, its value in the lab suffers from a lack of standardization regarding their optimal care, breeding, and housing. Filling the need for such a reference, The Laboratory Xenopus sp provides researchers and lab managers with a practical, step-by-step manual that emphasizes the humane care and use of captive clawed frogs in basic as well as biomedical, and toxicological research. The Only Book of Its Kind Available to Researchers Amply illustrated with 50 color illustrations of management practices and technical procedures, this how-to guide:Offers quick reference on the humane care and use of clawed frogs in the laboratoryIllustrates management practices and technical procedures with figures and tables Provides sources of additional information on frogs, feed, and sanitation suppliesSupported with hypothesis-driven research, this well-organized manual explores the full range of responsibilities facing individuals who work with this species. The content is divided into intentionally brief sections that allow for the quick retrieval of essential information regarding important biological features and experimental methodology, as well as compliance and veterinary care, husbandry, housing, and water quality management. The book has an accompanying website with more information, including interesting frog trivia.

Laboratory animals, including dogs, play an important role in biomedical research and medical advances. Dogs have a long history of use in research and have contributed enormously to the health and welfare of both humans and animals. The humane care and management of these animals is a fundamental component of their use in medical research.The Laboratory Canine clearly presents basic background information covering subjects that apply specifically to dogs used in research settings, such as basic biological features, husbandry, management, veterinary care, experimental methodology, and resources. The book offers guidance on performing a detailed physical examination, including necessary veterinary supplies, clinical signs of illness, clinical conditions, and reference tables of widely used veterinary drugs. It discusses the human-animal bond or the relationship between people and animals and its significance and importance to the quality of research, the health of the animals, and the emotional health of staff caring for or working with animals. It also examines anesthetic and surgical procedures that include pre-, intra-, and post-anesthesia/operative monitoring. The Laboratory Canine contains reference charts for monitoring patients through post-operative recovery and reference tables for anesthetics and analgesics. Because dogs are a highly visible species in the eyes of the public and regulators, it is important that individuals working with laboratory canines have the proper training and experience. This valuable resource is ideal for those charged with the care and use of canines in a research setting.

The Laboratory Hamster and Gerbil details basic information and common procedures for individuals performing research with hamsters and gerbils. It includes duties of animal facility management, animal husbandry, regulatory compliance, and technical procedures and assists in the humane care and use of hamsters and gerbils in the laboratory. It provides quick, easy-to-use information for investigators, technicians, and animal caretakers and includes references to alternative procedures and methods. The book also offers possible sources and suppliers of animals, feed, sanitation supplies, cages, and research and veterinary supplies.

This guide was created especially for individuals performing research with cats whose duties include animal facility management, animal husbandry, regulatory compliance, and technical procedures involved with their research. Basic information and common procedures are presented in detail.

Praise for the First Edition"This book is easy to read and has many informative illustrations…I would strongly recommend this book to those interested in a broad introduction to the care and use of laboratory guinea pigs as well as to laboratory animal technicians, managers, veterinarians and scientists who do not have direct access to large, well organized animal resource units with extensive library facilities."—John D. Young, Contemporary TopicsThe Laboratory Guinea Pig provides a compact and well- illustrated introduction to research on the guinea pig. The second edition of this popular handbook facilitates quick reference to the behavioral and physical traits of the guinea pig, as well as practical information on its unique anatomical and biological features. Numerous tables and color illustrations help the reader identify features of anatomy and understand health issues and care requirements. Supplying a stepwise introduction to common laboratory techniques, the new edition of this trusted reference provides guidance that supports the humane care and use of guinea pigs in the laboratory setting.

With laboratory animals, especially rabbits, playing such an important role in biomedical research, the humane care of these animals is an ongoing concern. The Laboratory Rabbit, Second Edition presents basic information and common procedures in detail to provide a quick reference for caretakers, technicians, and researchers in a laboratory setting. Now in full color, the second edition of this book illustrates management practices and technical procedures with numerous figures and tables. It includes updated tables on anesthetic agents, methods of euthanasia, recommended needle sizes, injection sites, approximate values for injection, and sedative and immobilization agents. Plastic comb-bound for convenient and frequent use, this guide also provides sources and suppliers of additional information on rabbits, feed, and sanitation supplies.

Even though Xenopus is one of the two most popular non-mammalian animals used in biomedical research, its value in the lab suffers from a lack of standardization regarding their optimal care, breeding, and housing. Filling the need for such a reference, The Laboratory Xenopus sp provides researchers and lab managers with a practical, step-by-step manual that emphasizes the humane care and use of captive clawed frogs in basic as well as biomedical, and toxicological research. The Only Book of Its Kind Available to ResearchersAmply illustrated with 50 color illustrations of management practices and technical procedures, this how-to guide: Offers quick reference on the humane care and use of clawed frogs in the laboratory Illustrates management practices and technical procedures with figures and tables Provides sources of additional information on frogs, feed, and sanitation suppliesSupported with hypothesis-driven research, this well-organized manual explores the full range of responsibilities facing individuals who work with this species. The content is divided into intentionally brief sections that allow for the quick retrieval of essential information regarding important biological features and experimental methodology, as well as compliance and veterinary care, husbandry, housing, and water quality management.The book has an accompanying website with more information, including interesting frog trivia.

Rats have long been recognized as a valuable biomedical research model, notably in the investigation of aging, toxicology, addiction, and common human diseases such as diabetes and hypertension. In many instances, individuals conducting such research studies are charged with important responsibilities, including animal facility management, animal husbandry, veterinary care, regulatory compliance, and various experimental methodologies. With the advent of genetic manipulations and biomedical research technological advances such as bioimaging, the versatility and usefulness of the rat as an animal model has soared. The Laboratory Rat, Second Edition captures the multiple advances in this important animal model’s husbandry, veterinary care, and experimental methodology. This edition features augmented, expanded, and novel information on biology, anesthesia, analgesia, and experimental techniques benefiting personnel working with rats—from the animal care staff to the researcher and everyone in between. The book is also extremely useful to institutional animal care and use program supporters and elements, including animal care and use committees, institutional officials, occupational health and safety professionals, veterinary technicians, and veterinarians.

Rats have long been recognized as a valuable biomedical research model, notably in the investigation of aging, toxicology, addiction, and common human diseases such as diabetes and hypertension. In many instances, individuals conducting such research studies are charged with important responsibilities, including animal facility management, animal h

Praise for the First Edition"This book is easy to read and has many informative illustrations…I would strongly recommend this book to those interested in a broad introduction to the care and use of laboratory guinea pigs as well as to laboratory animal technicians, managers, veterinarians and scientists who do not have direct access to large, well organized animal resource units with extensive library facilities."—John D. Young, Contemporary TopicsThe Laboratory Guinea Pig provides a compact and well- illustrated introduction to research on the guinea pig. The second edition of this popular handbook facilitates quick reference to the behavioral and physical traits of the guinea pig, as well as practical information on its unique anatomical and biological features. Numerous tables and color illustrations help the reader identify features of anatomy and understand health issues and care requirements. Supplying a stepwise introduction to common laboratory techniques, the new edition of this trusted reference provides guidance that supports the humane care and use of guinea pigs in the laboratory setting.

Key featuresContains 28 updated tables designed as quick, easy-to-use references for New and Old World speciesProvides over 100 photographs and illustrations, most now in color, depicting aspects of nonhuman primate biology, behavior, management practices, diseases, and technical proceduresGives a concise overview of regulatory considerations for the use of nonhuman primates in biomedical researchExpands the Veterinary Care chapter to include new sections on nutritional support, behavioral conditions, dental care, and updated information on anesthetic and analgesic drugsPresents step-by-step descriptions of common and advanced sampling techniquesIncludes extensive resource lists for vendors of animals, feed, sanitation supplies, caging, anesthetic equipment, and veterinary and research suppliesExtensively updated to include current literature, The Laboratory Nonhuman Primate, Second Edition, continues to serve as a quick reference source for technicians, caretakers, veterinarians, researchers, and students working with primates in biomedical research. It provides details on basic husbandry and covers biologic characteristics, regulatory compliance, common diseases, and anesthetic management.The text gives easy-to-follow descriptions of basic technical procedures including restraint, intubation, tuberculin skin testing, and collection of blood and urine samples. It also reviews advanced sampling procedures including collection of bone marrow, cerebrospinal fluid, bronchoalveolar lavage fluid, and rectal mucosal biopsy. The Laboratory Nonhuman Primate presents information in a clear, concise format to allow readers to incorporate concepts and techniques into the standard operating procedures of a facility.

Laboratory animals, including ferrets, play an important role in biomedical research and advances. The humane care and management of these animals remains an ongoing concern. Published in color to provide greater clarity to the techniques and concepts discussed, The Laboratory Ferret presents basic information and common procedures in detail to provide a quick reference for investigators, technicians, and caretakers in the laboratory setting. The book presents a greater understanding of the use of the ferret in research, such as in studies on influenza. It is a valuable, handy reference for experienced individuals and for those without extensive training in working with ferrets.

Rodents are the most commonly used species in biomedical research. Individuals conducting rodent research are often responsible to ensure that all areas of anesthesia and analgesia are performed humanely. Anesthetic agent selection, anesthetic monitoring, and postoperative pain assessment and management are essential to the institutional animal care and use program and contribute significantly to the 3Rs by reducing pain and/or distress and refining various procedures.The Handbook of Laboratory Animal Anesthesia and Pain Management: Rodents is the first book to capture multiple advances in this important area that greatly impacts various experimental methodologies. Richly illustrated in full color, the book serves as a quick reference source for investigators, veterinarians, technicians, and other animal caretakers charged with the care and use of rodents in a research setting. The unique format of this book also makes it extremely valuable to IACUC members, institutional officials, and occupational health and safety professionals.Key features:Presents practical information in easily accessible ‘bullet point’ format Covers anesthetic machine and related equipment, anesthetic management and monitoring, anesthesia and analgesia pharmacology, euthanasia, and record keepingWritten by well-recognized experts in the laboratory animal community Provides extensive references to direct the reader to sources for further study of alternative techniques and their proceduresConcludes with a thorough chapter on Regulatory Management of Rodent Anesthesia which has global application