Modern Trends in Molecular Biology – serie

This new volume discusses the widespread concerns of hematopoietic challenges in different and emerging ways. With chapters written by faculty and researchers from prestigious institutions working directly in hematopoiesis and advanced areas of biology, the volume offers a comprehensive overview of the regulation of blood cell development, epigenetic mechanisms, and regulatory non-coding RNAs. It presents concepts related to regulation of hematopoietic stem cell development, as well as survival, proliferation, and differentiation. It also discusses the microenvironmental niche where stem cells exist and develop into distinct blood cell types. A model system used to study non-coding RNA functions along with transformation of normal cells into cancer cell is elaborated on as well.Key features of the book:Details how to utilize the available investigative tools and techniques to isolate and study single blood cells in different model systemsDiscusses the epigenetics of hematopoiesisConsiders the clinical outcomes of defective hematopoiesisDescribes hematopoiesis and cancer stem cellsLooks at hematopoiesis in relation to specific diseases, such as minimal residual disease (MRD) and leukemiaThis book provides valuable information related to developments in hematopoiesis that will be helpful for understanding the basics of hematopoiesis and the clinical treatment of blood diseases. Hematopoiesis: Biochemical, Cellular, Molecular, and Genomic Perspectives will be valuable to clinicians, medical school students, and researchers working in hematology.

There has been a tremendous advancement in cancer therapeutics, and this book focuses on new approaches to one of the major cancers of the female reproductive system—cervical cancer. Cervical cancer is the fourth most frequent cancer in women worldwide and, especially, a foremost cause of morbidity in women in developing countries, including India. Several research findings have suggested that modulation in various signaling pathways is responsible for cervical cancer pathogenesis, and inhibition of these crucial pathways could be a better therapeutic approach for cervical cancer management. This book expounds on this approach, providing a detailed insight of the deregulated oncogenic signaling pathways involved in the progression of cervical cancer.The key topics covered within this book includeSignaling pathways involved in cervical cancerMechanisms behind the involvement of these aberrant signaling pathwaysCell signaling pathways and their alterations in cancerMolecular biology behind cervical cancerDrug development approaches for the management of cervical cancerCervical cancer therapeutics and the possible aspects, including progression and inhibition using natural products and synthetic approachesOncologists, cancer scientists, and research professionals will benefit from this volume, which provides a single platform that presents new research on the pathways responsible for the progression of cervical cancer so that they, in turn, can design their research work effectively and can discover novel innovations in the field of cancer therapeutics.