Oxford Chemistry Masters – serie

Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, but especially on drug discovery. This informative text explains the origins of combinatorial chemistry and puts the many diverse library methods into context. It explains why some techniques are generally applicable and others are for specialists only. It also focuses on the renaissance of solid phase chemistry and describes the range of available reactions. This is the first single author book in this important, growing field and it describes the beneficial impact of combinatorial chemistry, espcially for the discovery and optimization of biologically active molecules.This concise and comprehensive overview of combinatorial techniques is an essential text for final year undergraduates, postgraduates, academics, and industrialists in chamistry, bioorganic chemistry, medicinal chemistry, and drug discovery. it provides an accessible introduction to the area for those new to these methods and a valuable reference text to those experienced in the field.

Scientists have been enthusiastic advocates of computational methods of data analysis for as long as computers have been widely available. This book introduces the growing range of computational methods which arise from research into Artificial Intelligence (AI), and which are coming to be recognised as tools of great potential in modern scientific analysis. These methods offer tremendous potential in the analysis of scientific data: papers reporting the application of AI methods in chemistry are currently being published at a rate of several hundred a year; similar figures apply to other areas of science, and the numbers are increasing rapidly. This book leads the reader into the relevant research literature, and provides both the principles and applications of the subject at a level accessible to senior undergraduates and beginning postgraduates.

Carbohydrates are associated with a plethora of important biological processes and have been implicated in the onset and progress of many lethal diseases. They have attracted a great deal of recent research interest from both synthetic chemists and glycobiologists, and have been identified as novel targets of therapeutic importance. This book, which is aimed at synthetic and medicinal chemists, hopes to introduce both undergraduates and research students to the chemistry and biology of carbohydrates. The book investigates methods for synthesising carbohydrates in a systematic and logical manner and provides real examples from the literature to exemplify the procedures introduced. Both traditional and modern methods for synthesising carbohydrates, including enzymatic and solid- phase techniques, are discussed.

This book describes the principles and concepts of biomineralization and their application in the new field of biomimetic materials chemistry. The main focus is on the principles and concepts that arise from a chemical perspective of biomineralization. After surveying the major types of biominerals (chapter 2) the general principles of biomineralization are discussed (chapter 3), followed by a detailed description of the chemical aspects of biomineralization (chapter 4). The next four chapters are concerned with the process of biomineralization, including boundary-organized biomineralization (chapter 5), organic matrix-mediated biomineralization (chapter 6), morphogenesis (chapter 7) and biomineral tectonics (chapter 8). The final chapter describes how current knowledge of biomineralization is inspiring new biomimetic strategies in synthetic materials chemistry.