Studies in Mechanobiology, Tissue Engineering and Biomaterials – serie

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50 produkter

Del 22 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Skin Biophysics
From Experimental Characterisation to Advanced Modelling
AvGeorges Limbert
Inbunden, Engelska, 2019
1 729 kr
Skickas inom 10-15 vardagar
This book presents state-of-the-art experimental and modelling techniques for skin biophysics that are currently used in academic and industrial research. It also identifies current and future challenges, as well as a growing number of opportunities in this exciting research field. The book covers the basics of skin physiology, biology, microstructural and material properties, and progressively introduces the reader to established experimental characterisation protocols and modelling approaches. Advanced topics in modelling theories and numerical implementation are also presented.The book focusses especially on:1. Basic physiology, molecular biology, microstructural and material properties of the skin.2. Experimental characterisation techniques for the skin (including imaging): in vivo and in vitro techniques and combination of those with in silico approaches.3. State-of-the-art constitutivemodels of the skin: elastic, anelastic and mechanobiological formulations (e.g. growth, ageing, healing).4. Applications: mechanics, damage, biological growth, healing, ageing and skin tribology.This book is addressed to postgraduate students in biomedical/mechanical/civil engineering, (bio)physics and applied mathematics, postdoctoral researchers, as well as scientists and engineers working in academia and industry engaged in skin research, particularly, if at the cross-roads of physical experiments, imaging and modelling. The book is also be of interest to clinicians/biologists who wish to learn about the possibilities offered by modern engineering techniques for skin science research and, by so doing, provide them with an incentive to broaden their outlook, engage more widely with the non-clinical research communities and, ultimately, help cross-fertilising new ideas that will lead to better treatment plans and engineering solutions.
Del 22 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Skin Biophysics
From Experimental Characterisation to Advanced Modelling
AvGeorges Limbert
Häftad, Engelska, 2020
1 477 kr
Skickas inom 5-8 vardagar
This book presents state-of-the-art experimental and modelling techniques for skin biophysics that are currently used in academic and industrial research. It also identifies current and future challenges, as well as a growing number of opportunities in this exciting research field. The book covers the basics of skin physiology, biology, microstructural and material properties, and progressively introduces the reader to established experimental characterisation protocols and modelling approaches. Advanced topics in modelling theories and numerical implementation are also presented.The book focusses especially on:1. Basic physiology, molecular biology, microstructural and material properties of the skin.2. Experimental characterisation techniques for the skin (including imaging): in vivo and in vitro techniques and combination of those with in silico approaches.3. State-of-the-art constitutivemodels of the skin: elastic, anelastic and mechanobiological formulations (e.g. growth, ageing, healing).4. Applications: mechanics, damage, biological growth, healing, ageing and skin tribology.This book is addressed to postgraduate students in biomedical/mechanical/civil engineering, (bio)physics and applied mathematics, postdoctoral researchers, as well as scientists and engineers working in academia and industry engaged in skin research, particularly, if at the cross-roads of physical experiments, imaging and modelling. The book is also be of interest to clinicians/biologists who wish to learn about the possibilities offered by modern engineering techniques for skin science research and, by so doing, provide them with an incentive to broaden their outlook, engage more widely with the non-clinical research communities and, ultimately, help cross-fertilising new ideas that will lead to better treatment plans and engineering solutions.
Del 23 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Multi-scale Extracellular Matrix Mechanics and Mechanobiology
AvYanhang Zhang
Inbunden, Engelska, 2019
1 155 kr
Skickas inom 10-15 vardagar
This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms.
Del 23 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Multi-scale Extracellular Matrix Mechanics and Mechanobiology
AvYanhang Zhang
Häftad, Engelska, 2020
1 155 kr
Skickas inom 10-15 vardagar
This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms.
Del 24 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Solid (Bio)mechanics: Challenges of the Next Decade
A Book Dedicated to Professor Gerhard A. Holzapfel
AvGerhard Sommer,Kewei Lim. fl.
Inbunden, Engelska, 2022
2 074 kr
Skickas inom 10-15 vardagar
This book offers a comprehensive and timely overview of the latest developments in the field of biomechanics and extensive knowledge of tissue structure, function, and modeling. Gathering chapters written by authoritative scientists, it reports on a range of continuum and computational models of solids, and related experimental works, for biomechanical applications. It discusses cutting-edge advances such as constitutive modeling and computational simulation of biological tissues and organs under physiological and pathological conditions, and their mechanical characterization. It covers innovative studies on arteries, heart, valvular tissue, and thrombus, brain tumor, muscle, liver, kidney, and stomach, among others. Written in honor of Professor Gerhard A. Holzapfel, the book provides specialized readers with a thorough and timely overview of different types ofmodeling in biomechanics, and current knowledge about biological structures and function.
Del 24 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Solid (Bio)mechanics: Challenges of the Next Decade
A Book Dedicated to Professor Gerhard A. Holzapfel
AvGerhard Sommer,Kewei Lim. fl.
Häftad, Engelska, 2023
2 074 kr
Skickas inom 10-15 vardagar
This book offers a comprehensive and timely overview of the latest developments in the field of biomechanics and extensive knowledge of tissue structure, function, and modeling. Gathering chapters written by authoritative scientists, it reports on a range of continuum and computational models of solids, and related experimental works, for biomechanical applications. It discusses cutting-edge advances such as constitutive modeling and computational simulation of biological tissues and organs under physiological and pathological conditions, and their mechanical characterization. It covers innovative studies on arteries, heart, valvular tissue, and thrombus, brain tumor, muscle, liver, kidney, and stomach, among others. Written in honor of Professor Gerhard A. Holzapfel, the book provides specialized readers with a thorough and timely overview of different types ofmodeling in biomechanics, and current knowledge about biological structures and function.
Del 25 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Physical Principles of Electro-Mechano-Biology
Multiphysics and Supramolecular Approaches
AvChristian Brosseau
Inbunden, Engelska, 2023
1 679 kr
Skickas inom 10-15 vardagar
This book covers the recently developed understanding of Electro-Mechano-Biology (EMB) in which the focus is primarily on the couplings between the electric and mechanical fields. The emphasis lies on the analytical and computational aspects of EMB at the cellular level. The book is divided into two parts. In the first part, the author starts by defining and discussing the relevant basic aspects of the electrical and mechanical properties of cell membranes. He provides an overview of some of the ways analytical modelling of cell membrane electrodeformation (ED) and electroporation (EP) appears in a variety of contexts as well as a contemporary account of recent developments in computational approaches that can feature in the theory initiative, particularly in its attempt to describe the cohort of activities currently underway. Intended to serve as an introductory text and aiming to facilitate the understanding of the field to non-experts, this part does not dwell on the set of topics, such as cellular mechanosensing and mechanotransduction, irreversible EP, and atomistic molecular dynamics modelling of membrane EP. The second (and larger) part of the book is devoted to a presentation of the necessary analytical and computational tools to illustrate the ideas behind EMB and illuminate physical insights. Brief notes on the history of EMB and its many applications describing the variety of ideas and approaches are also included. In this part, the background of the first principles and practical calculation methods are discussed to highlight aspects that cannot be found in a single volume.
Del 25 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Physical Principles of Electro-Mechano-Biology
Multiphysics and Supramolecular Approaches
AvChristian Brosseau
Häftad, Engelska, 2024
1 679 kr
Skickas inom 10-15 vardagar
This book covers the recently developed understanding of Electro-Mechano-Biology (EMB) in which the focus is primarily on the couplings between the electric and mechanical fields. The emphasis lies on the analytical and computational aspects of EMB at the cellular level. The book is divided into two parts. In the first part, the author starts by defining and discussing the relevant basic aspects of the electrical and mechanical properties of cell membranes. He provides an overview of some of the ways analytical modelling of cell membrane electrodeformation (ED) and electroporation (EP) appears in a variety of contexts as well as a contemporary account of recent developments in computational approaches that can feature in the theory initiative, particularly in its attempt to describe the cohort of activities currently underway. Intended to serve as an introductory text and aiming to facilitate the understanding of the field to non-experts, this part does not dwell on the set of topics, such as cellular mechanosensing and mechanotransduction, irreversible EP, and atomistic molecular dynamics modelling of membrane EP. The second (and larger) part of the book is devoted to a presentation of the necessary analytical and computational tools to illustrate the ideas behind EMB and illuminate physical insights. Brief notes on the history of EMB and its many applications describing the variety of ideas and approaches are also included. In this part, the background of the first principles and practical calculation methods are discussed to highlight aspects that cannot be found in a single volume.
Del 16 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Mechanobiology of Obesity and Related Diseases
AvAmit Gefen,Dafna Benayahu
Inbunden, Engelska, 2014
1 155 kr
Skickas inom 10-15 vardagar
This volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases.There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors.
Del 17 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Uncertainty in Biology
A Computational Modeling Approach
AvLiesbet Geris,David Gomez-Cabrero
Inbunden, Engelska, 2015
1 155 kr
Skickas inom 10-15 vardagar
Computational modeling allows to reduce, refine and replace animal experimentation as well as to translate findings obtained in these experiments to the human background. However these biomedical problems are inherently complex with a myriad of influencing factors, which strongly complicates the model building and validation process. This book wants to address four main issues related to the building and validation of computational models of biomedical processes: 1. Modeling establishment under uncertainty 2. Model selection and parameter fitting 3. Sensitivity analysis and model adaptation 4. Model predictions under uncertainty In each of the abovementioned areas, the book discusses a number of key-techniques by means of a general theoretical description followed by one or more practical examples. This book is intended for graduate students and researchers active in the field of computational modeling of biomedical processes who seek to acquaint themselves with the different ways in which to study the parameter space of their model as well as its overall behavior.
Microsystems for Enhanced Control of Cell Behavior
Fundamentals, Design and Manufacturing Strategies, Applications and Challenges
AvAndrés Díaz Lantada
Inbunden, Engelska, 2016
1 674 kr
Skickas inom 10-15 vardagar
This handbook focuses on the entire development process of biomedical microsystems that promote special interactions with cells. Fundamentals of cell biology and mechanobiology are described as necessary preparatory input for design tasks. Advanced design, simulation, and micro/nanomanufacturing resources, whose combined use enables the development of biomedical microsystems capable of interacting at a cellular level, are covered in depth. A detailed series of chapters is then devoted to applications based on microsystems that offer enhanced cellular control, including microfluidic devices for diagnosis and therapy, cell-based sensors and actuators (smart biodevices), microstructured prostheses for improvement of biocompatibility, microstructured and microtextured cell culture matrices for promotion of cell growth and differentiation, electrophoretic microsystems for study of cell mechanics, microstructured and microtextured biodevices for study of cell adhesion and dynamics, and biomimetic microsystems (including organs-on-chips), among others. Challenges relating to the development of reliable in vitro biomimetic microsystems, the design and manufacture of complex geometries, and biofabrication are also discussed.
Del 19 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Mechanobiology and Mechanophysiology of Military-Related Injuries
AvAmit Gefen,Yoram Epstein
Inbunden, Engelska, 2016
1 155 kr
Skickas inom 10-15 vardagar
Thisbook provides a state-of-the-art update, as well as perspectives on futuredirections of research and clinical applications in the implementation ofbiomechanical and biophysical experimental, theoretical and computationalmodels which are relevant to military medicine. Such experimental and modelingefforts are helpful, on the one hand, in understanding the aetiology,pathophysiology and dynamics of injury development and on the other hand inguiding the development of better equipment and protective gear or devices thatshould ultimately reduce the prevalence and incidence of injuries or lessentheir hazardous effects. The book is useful for military-oriented biomedicalengineers and medical physicists, as well as for military physiologists andother medical specialists who are interested in the science and technologyimplemented in modern investigations of military related injuries.
Del 17 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Uncertainty in Biology
A Computational Modeling Approach
AvLiesbet Geris,David Gomez-Cabrero
Häftad, Engelska, 2016
1 155 kr
Skickas inom 10-15 vardagar
Computational modeling allows to reduce, refine and replace animal experimentation as well as to translate findings obtained in these experiments to the human background. However these biomedical problems are inherently complex with a myriad of influencing factors, which strongly complicates the model building and validation process. This book wants to address four main issues related to the building and validation of computational models of biomedical processes: 1. Modeling establishment under uncertainty 2. Model selection and parameter fitting 3. Sensitivity analysis and model adaptation 4. Model predictions under uncertainty In each of the abovementioned areas, the book discusses a number of key-techniques by means of a general theoretical description followed by one or more practical examples. This book is intended for graduate students and researchers active in the field of computational modeling of biomedical processes who seek to acquaint themselves with the different ways in which to study the parameter space of their model as well as its overall behavior.
Del 16 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Mechanobiology of Obesity and Related Diseases
AvAmit Gefen,Dafna Benayahu
Häftad, Engelska, 2016
1 152 kr
Skickas inom 10-15 vardagar
This volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases.There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors.
Del 20 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Biomechanics: Trends in Modeling and Simulation
AvGerhard A. Holzapfel,Ray W. Ogden
Inbunden, Engelska, 2016
1 844 kr
Skickas inom 10-15 vardagar
The book presents a state-of-the-art overview of biomechanical and mechanobiological modeling and simulation of soft biological tissues. Seven well-known scientists working in that particular field discuss topics such as biomolecules, networks and cells as well as failure, multi-scale, agent-based, bio-chemo-mechanical and finite element models appropriate for computational analysis. Applications include arteries, the heart, vascular stents and valve implants as well as adipose, brain, collagenous and engineered tissues.The mechanics of the whole cell and sub-cellular components as well as the extracellular matrix structure and mechanotransduction are described. In particular, the formation and remodeling of stress fibers, cytoskeletal contractility, cell adhesion and the mechanical regulation of fibroblast migration in healing myocardial infarcts are discussed. The essential ingredients of continuum mechanics are provided. Constitutive models of fiber-reinforced materials with anemphasis on arterial walls and the myocardium are discussed and the important influence of residual stresses on material response emphasized. The mechanics and function of the heart, the brain and adipose tissues are discussed as well. Particular attention is focused on microstructural and multi-scale modeling, finite element implementation and simulation of cells and tissues.
Del 21 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Regenerative Strategies for the Treatment of Knee Joint Disabilities
AvJoaquim Miguel Oliveira,Rui Luís Reis
Inbunden, Engelska, 2016
1 155 kr
Skickas inom 10-15 vardagar
This book presents regenerative strategies for the treatment of knee joint disabilities. The book is composed of four main sections totaling 19 chapters which review the current knowledge on the clinical management and preclinical regenerative strategies. It examines the role of different natural-based biomaterials as scaffolds and implants for addressing different tissue lesions in the knee joint. Section one provides an updated and comprehensive discussion on articular cartilage tissue regeneration. Section two focuses on the important contributions for bone and osteochondral tissue engineering. Section three overview the recent advances on meniscus repair/regeneration strategies. Finally, section four further discusses the current strategies for treatment of ligament lesions. Each chapter is prepared by world know expert on their fields, so we do firmly believe that the proposed book will be a reference in the area of biomaterials for regenerative medicine.
Microsystems for Enhanced Control of Cell Behavior
Fundamentals, Design and Manufacturing Strategies, Applications and Challenges
AvAndrés Díaz Lantada
Häftad, Engelska, 2018
2 087 kr
Skickas inom 5-8 vardagar
This handbook focuses on the entire development process of biomedical microsystems that promote special interactions with cells. Fundamentals of cell biology and mechanobiology are described as necessary preparatory input for design tasks. Advanced design, simulation, and micro/nanomanufacturing resources, whose combined use enables the development of biomedical microsystems capable of interacting at a cellular level, are covered in depth. A detailed series of chapters is then devoted to applications based on microsystems that offer enhanced cellular control, including microfluidic devices for diagnosis and therapy, cell-based sensors and actuators (smart biodevices), microstructured prostheses for improvement of biocompatibility, microstructured and microtextured cell culture matrices for promotion of cell growth and differentiation, electrophoretic microsystems for study of cell mechanics, microstructured and microtextured biodevices for study of cell adhesion and dynamics, and biomimetic microsystems (including organs-on-chips), among others. Challenges relating to the development of reliable in vitro biomimetic microsystems, the design and manufacture of complex geometries, and biofabrication are also discussed.
Del 19 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Mechanobiology and Mechanophysiology of Military-Related Injuries
AvAmit Gefen,Yoram Epstein
Häftad, Engelska, 2018
1 152 kr
Skickas inom 10-15 vardagar
Thisbook provides a state-of-the-art update, as well as perspectives on futuredirections of research and clinical applications in the implementation ofbiomechanical and biophysical experimental, theoretical and computationalmodels which are relevant to military medicine. Such experimental and modelingefforts are helpful, on the one hand, in understanding the aetiology,pathophysiology and dynamics of injury development and on the other hand inguiding the development of better equipment and protective gear or devices thatshould ultimately reduce the prevalence and incidence of injuries or lessentheir hazardous effects. The book is useful for military-oriented biomedicalengineers and medical physicists, as well as for military physiologists andother medical specialists who are interested in the science and technologyimplemented in modern investigations of military related injuries.
Del 20 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Biomechanics: Trends in Modeling and Simulation
AvGerhard A. Holzapfel,Ray W. Ogden
Häftad, Engelska, 2018
1 844 kr
Skickas inom 10-15 vardagar
The book presents a state-of-the-art overview of biomechanical and mechanobiological modeling and simulation of soft biological tissues. Seven well-known scientists working in that particular field discuss topics such as biomolecules, networks and cells as well as failure, multi-scale, agent-based, bio-chemo-mechanical and finite element models appropriate for computational analysis. Applications include arteries, the heart, vascular stents and valve implants as well as adipose, brain, collagenous and engineered tissues.The mechanics of the whole cell and sub-cellular components as well as the extracellular matrix structure and mechanotransduction are described. In particular, the formation and remodeling of stress fibers, cytoskeletal contractility, cell adhesion and the mechanical regulation of fibroblast migration in healing myocardial infarcts are discussed. The essential ingredients of continuum mechanics are provided. Constitutive models of fiber-reinforced materials with anemphasis on arterial walls and the myocardium are discussed and the important influence of residual stresses on material response emphasized. The mechanics and function of the heart, the brain and adipose tissues are discussed as well. Particular attention is focused on microstructural and multi-scale modeling, finite element implementation and simulation of cells and tissues.
Regenerative Strategies for the Treatment of Knee Joint Disabilities
AvJoaquim Miguel Oliveira,Rui Luís Reis
Häftad, Engelska, 2018
1 493 kr
Skickas inom 5-8 vardagar
This book presents regenerative strategies for the treatment of knee joint disabilities. The book is composed of four main sections totaling 19 chapters which review the current knowledge on the clinical management and preclinical regenerative strategies. It examines the role of different natural-based biomaterials as scaffolds and implants for addressing different tissue lesions in the knee joint. Section one provides an updated and comprehensive discussion on articular cartilage tissue regeneration. Section two focuses on the important contributions for bone and osteochondral tissue engineering. Section three overview the recent advances on meniscus repair/regeneration strategies. Finally, section four further discusses the current strategies for treatment of ligament lesions. Each chapter is prepared by world know expert on their fields, so we do firmly believe that the proposed book will be a reference in the area of biomaterials for regenerative medicine.
Bioengineering Research of Chronic Wounds
A Multidisciplinary Study Approach
AvAmit Gefen
Inbunden, Engelska, 2009
1 729 kr
Skickas inom 10-15 vardagar
Pressure-related chronic wounds are an important health concern that affects millions of patients and accumulates billions in annual costs. These wounds may occur when soft tissues are mechanically compressed between bony prominences and a supporting surface. This book gives a complete and quantitative explanation of the mechanobiology which causes chronic wounds. The reviews give an overall picture on all length scales of the phenomenon, starting from musculoskeletal biomechanics to the modeling of soft tissues and their interaction with bones. At the microscopic levels, it thoroughly reviews experiments and modeling of cellular forces and molecular processes that occur during injury and healing, including the integrity of living cells subjected to sustained mechanical forces and deformations. The results allow a complete picture of the tolerance of human tissues to sustained loads, and an understanding of the risk for onset of chronic wounds. Hence, this book is also valuable for all professionals involved in the prevention and treatment of chronic wounds.
Del 3 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Neural Tissue Biomechanics
AvLynne E. Bilston
Inbunden, Engelska, 2011
1 729 kr
Skickas inom 10-15 vardagar
Damage to the central nervous system resulting from pathological mechanical loading can occur as a result of trauma or disease. Such injuries lead to significant disability and mortality. The peripheral nervous system, while also subject to injury from trauma and disease, also transduces physiological loading to give rise to sensation, and mechanotransduction is also thought to play a role in neural development and growth. This book gives a complete and quantitative description of the fundamental mechanical properties of neural tissues, and their responses to both physiological and pathological loading. This book reviews the methods used to characterize the nonlinear viscoelastic properties of central and peripheral neural tissues, and the mathematical and sophisticated computational models used to describe this behaviour. Mechanisms and models of neural injury from both trauma and disease are reviewed from the molecular to macroscopic scale. The book provides a comprehensive picture of the mechanical and biological response of neural tissues to the full spectrum of mechanical loading to which they are exposed. This book provides a comprehensive reference for professionals involved in pre prevention of injury to the nervous system, whether this arises from trauma or disease.
Biomaterials as Stem Cell Niche
AvKrishnendu Roy
Inbunden, Engelska, 2010
1 729 kr
Skickas inom 10-15 vardagar
Recent developments in stem cell biology have opened new directions in cell therapy. This book provides the state-of-the-art developments in using biomaterials as artificial niches for engineering stem cells, both for the purpose of better understanding their biology under 3D biomimetic conditions as well as for developing new strategies for efficient long term maintenance and directed differentiation of stem cells into various therapeutic lineages. Animal and human stem cells of both embryonic and adult origin are discussed with applications ranging from nerve regeneration, orthopedics, cardiovascular therapy, blood cell generation and cancer therapy. Both synthetic and natural biomaterials are reviewed with emphasis on how material-stem cell interactions direct specific signaling pathways and ultimately modulate the cell fate. This book is valuable for biomaterial scientists, tissue engineers, clinicians as well as stem cell biologists involved in basic research and applications of adult and embryonic stem cells.
Cellular and Biomolecular Mechanics and Mechanobiology
AvAmit Gefen
Inbunden, Engelska, 2011
1 729 kr
Skickas inom 10-15 vardagar
This book describes these exciting new developments, and presents experimental and computational findings that altogether describe the frontier of knowledge in cellular and biomolecular mechanics, and the biological implications, in health and disease. The book is written for bioengineers with interest in cellular mechanics, for biophysicists, biochemists, medical researchers and all other professionals with interest in how cells produce and respond to mechanical loads.
Del 5 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Skeletal Aging and Osteoporosis
Biomechanics and Mechanobiology
AvMatthew J. Silva
Inbunden, Engelska, 2012
1 155 kr
Skickas inom 10-15 vardagar
The focus of this book is on mechanical aspects of skeletal fragility related to aging and osteoporosis. Topics include: Age-related changes in trabecular structure and strength; age-related changes in cortical material properties; age-related changes in whole-bone structure; predicting bone strength and fracture risk using image-based methods and finite element analysis; animal models of osteoporosis and aging; age-related changes in skeletal mechano responsiveness; exercise and physical interventions for osteoporosis.
Del 6 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Myocardial Tissue Engineering
AvAldo R. Boccaccini,Sian Harding
Inbunden, Engelska, 2011
1 729 kr
Skickas inom 10-15 vardagar
Myocardial tissue engineering (MTE), a concept that intends to prolong patients’ life after cardiac damage by supporting or restoring heart function, is continuously improving. Common MTE strategies include an engineered ‘vehicle’, which may be a porous scaffold or a dense substrate or patch, made of either natural or synthetic polymeric materials. The function of the substrate is to aid transportation of cells into the diseased region of the heart and support their integration. This book, which contains chapters written by leading experts in MTE, gives a complete analysis of the area and presents the latest advances in the field. The chapters cover all relevant aspects of MTE strategies, including cell sources, specific TE techniques and biomaterials used. Many different cell types have been suggested for cell therapy in the framework of MTE, including autologous bone marrow-derived or cardiac progenitors, as well as embryonic or induced pluripotent stem cells, each having their particular advantages and disadvantages. The book covers a complete range of biomaterials, examining different aspects of their application in MTE, such as biocompatibility with cardiac cells, mechanical capability and compatibility with the mechanical properties of the native myocardium as well as degradation behaviour in vivo and in vitro. Although a great deal of research is being carried out in the field, this book also addresses many questions that still remain unanswered and highlights those areas in which further research efforts are required. The book will also give an insight into clinical trials and possible novel cell sources for cell therapy in MTE.
Del 8 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Active Implants and Scaffolds for Tissue Regeneration
AvMeital Zilberman
Inbunden, Engelska, 2011
1 729 kr
Skickas inom 10-15 vardagar
Active implants are actually drug or protein-eluting implants that induce healing effects, in addition to their regular task, such as support. This effect is achieved by controlled release of the active agent to the surrounding tissue. This book will give a broad overview of biomaterial platforms used as basic elements of drug-eluting implants. It will include mainly coatings for vascular stents with controlled release of antiproliferative agents, wound dressings with controlled release of antibacterial agents, drug-eluting vascular grafts, protein-eluting scaffolds for tissue regeneration, drug-eluting platforms for dental and other applications. Thus, both internal and external implants are described. The drug-eluting implants will be described in terms of matrix formats and polymers, incorporated drugs and their release profiles from the implants, as well as implant functioning. Smart polymeric systems, such as crosslinked poly-lactones, thermo and pH-sensitive hydrogels and poly(amido-amines), as well as novel basic structural elements, such as composite fibers and films, and nanostructures will be thoroughly described. The effect of the processing parameters on the microstructure and on the resulting drug release profiles, mechanical and physical properties, and other relevant properties, will be emphasized. The described new biomaterials approaches for active implants enhance the tools available for creating clinically important biomedical applications.
Del 7 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Biomechanics and Mechanobiology of Aneurysms
AvTim McGloughlin
Inbunden, Engelska, 2011
1 729 kr
Skickas inom 10-15 vardagar
Cardiovascular disease is the leading cause of morbidity and premature death of modern era medicine. It is estimated that approximately 81 million people in the United States (US) currently have one or more of the many forms of cardiovascular disease, resulting in 1 in every 2.8 deaths, or 900,000 deaths per year. 40% of all deaths in Europe are a result of cardiovascular disease in people under the age of 75. Aneurysms form a significant portion of these cardiovascular related deaths and are defined as a permanent and irreversible localised dilation of a blood vessel greater than 50% of its normal diameter. Although aneurysms can form in any blood vessel, the more lethal aneurysms develop in the cranial arteries, and in the thoracic aorta and abdominal aorta. Frequently aneurysms are undetected and if left untreated may eventually expand until rupture with very high levels of morbidity and mortality. The biomechanics and mechanobiology of aneursymal diseases are not fully understood and this monograph aims to provide new insights into aneurysm aetiology and behavior based on the most recent biomechanics research related to this important topic. The contributors to this volume bring together a unique blend of expertise in experimental, computational and tissue biomechanics relating to aneurysm behavior and enable the reader to gain a fresh understanding of key factors influencing aneurysm behavior and treatment. Biological risk factors such as tobacco smoking, sex, age, hypertension, family history and mechanobiological risk factors such as aneurysm geometry and shape as well as mechanical properties of the diseased tissues are considered in detail as are many of the diagnostic and treatment options.
Del 9 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Patient-Specific Modeling in Tomorrow's Medicine
AvAmit Gefen
Inbunden, Engelska, 2012
1 729 kr
Skickas inom 10-15 vardagar
This book reviews the frontier of research and clinical applications of Patient Specific Modeling, and provides a state-of-the-art update as well as perspectives on future directions in this exciting field. The book is useful for medical physicists, biomedical engineers and other engineers who are interested in the science and technology aspects of Patient Specific Modeling, as well as for radiologists and other medical specialists who wish to be updated about the state of implementation.
Del 1 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
Bioengineering Research of Chronic Wounds
A Multidisciplinary Study Approach
AvAmit Gefen
Häftad, Engelska, 2012
1 729 kr
Skickas inom 10-15 vardagar
Pressure-related chronic wounds are an important health concern that affects millions of patients and accumulates billions in annual costs. These wounds may occur when soft tissues are mechanically compressed between bony prominences and a supporting surface. This book gives a complete and quantitative explanation of the mechanobiology which causes chronic wounds. The reviews give an overall picture on all length scales of the phenomenon, starting from musculoskeletal biomechanics to the modeling of soft tissues and their interaction with bones. At the microscopic levels, it thoroughly reviews experiments and modeling of cellular forces and molecular processes that occur during injury and healing, including the integrity of living cells subjected to sustained mechanical forces and deformations. The results allow a complete picture of the tolerance of human tissues to sustained loads, and an understanding of the risk for onset of chronic wounds. Hence, this book is also valuable for all professionals involved in the prevention and treatment of chronic wounds.

Studies in Mechanobiology, Tissue Engineering and Biomaterials – serie

Skin Biophysics

Skin Biophysics

Multi-scale Extracellular Matrix Mechanics and Mechanobiology

Multi-scale Extracellular Matrix Mechanics and Mechanobiology

Solid (Bio)mechanics: Challenges of the Next Decade

Solid (Bio)mechanics: Challenges of the Next Decade

Physical Principles of Electro-Mechano-Biology

Physical Principles of Electro-Mechano-Biology

Mechanobiology of Obesity and Related Diseases

Uncertainty in Biology

Microsystems for Enhanced Control of Cell Behavior

Mechanobiology and Mechanophysiology of Military-Related Injuries

Uncertainty in Biology

Mechanobiology of Obesity and Related Diseases

Biomechanics: Trends in Modeling and Simulation

Regenerative Strategies for the Treatment of Knee Joint Disabilities

Microsystems for Enhanced Control of Cell Behavior

Mechanobiology and Mechanophysiology of Military-Related Injuries

Biomechanics: Trends in Modeling and Simulation

Regenerative Strategies for the Treatment of Knee Joint Disabilities

Bioengineering Research of Chronic Wounds

Neural Tissue Biomechanics

Biomaterials as Stem Cell Niche

Cellular and Biomolecular Mechanics and Mechanobiology

Skeletal Aging and Osteoporosis

Myocardial Tissue Engineering

Active Implants and Scaffolds for Tissue Regeneration

Biomechanics and Mechanobiology of Aneurysms

Patient-Specific Modeling in Tomorrow's Medicine

Bioengineering Research of Chronic Wounds