Ocular Periphery and Disorders

Dr. D’Amore earned her PhD in Biology from Boston University, was a postdoctoral fellow in Biological Chemistry and Ophthalmology at Johns Hopkins Medical School, then moved to Boston Children’s Hospital as Assistant Professor where she remains Research Associate in Surgery. In 1998, she became Charles L. Schepens Professor of Ophthalmology and Professor of Pathology at Harvard Medical School and a Senior Scientist at Mass. Eye and Ear. She is the Associate Chief of Basic and Translational Research for Ophthalmology at Mass. Eye and Ear and the Vice Chair of Basic and Translational Research for the Department of Ophthalmology. Dr. D’Amore is an international expert in vascular growth and development and has been at the forefront of angiogenesis research for over three decades. She has published more than 170 peer-reviewed papers, 75 reviews, and edited or co-edited two books. In addition to his role as Senior Scientist and Co-Director at the Schepens Eye Research Institute, Dr. Reza Dana holds the Claes H. Dohlman Chair in Ophthalmology at Harvard Medical School. He is Director of the Cornea & Refractive Surgery Service at the Massachusetts Eye & Ear, and serves as the Vice Chairman of the Harvard Department of Ophthalmology and Associate Chief of Ophthalmology for Academic Programs at Massachusetts Eye and Ear. After graduating Summa Cum Laude from St. Paul’s School in New Hampshire, he completed his bachelor’s (Phi Beta Kappa), graduate, and medical education at Johns Hopkins University. He performed his residency in Ophthalmology at the Illinois Eye and Ear Infirmary in Chicago, followed by a clinical fellowship in Cornea and External Diseases at the Wills Eye Hospital in Philadelphia. Reza then completed additional fellowship training in Immunology and Uveitis at the Massachusetts Eye and Ear Infirmary, and in Ocular and Transplantation Immunology at the Schepens Eye Research Institute. Dr. Dana also holds a Master of Science degree in Management from Harvard University. Reza has been a member of the full-time Harvard faculty since 1995. As a clinician-scientist, he has a particular interest in the molecular and cellular mechanisms of inflammation as they pertain to the ocular surface and anterior segment pathologies, including dry eye, allergy, wound healing responses, and transplant rejection.

• I. Anatomy and Pathophysiology of Blinking and Eye MovementsEyelid anatomy and the pathophysiology of blinkingDifferentiation and morphogenesis of extraocular musclesExtraocular muscle anatomyExtracocular muscle metabolismExtraocular muscles: proprioception and proprioceptorsAbnormal eye movements due to disease of the extraocular muscles and their innervationExtraocular muscles: functional assessment in the clinicII. Structure and Function of the Tear Film, Ocular Adnexa, Cornea, and Conjunctiva in Health and Pathogenesis in DiseaseMeibomian glands and lipid layerLacrimal gland overviewLacrimal gland hormone regulationLacrimal gland signaling-neuralLids: Anatomy, pathophysiology, and mucocutaneous junctionOcular surface-overview of electrolyte and fluid transport across the conjunctivaConjunctival Goblet cellsOcular mucinsTear drainageCornea overviewCorneal epithelium-cell biology and basic scienceCorneal nerves-anatomyCorneal nerves-functionCorneal epithelium-wound healing junctions, attachment to stroma receptors, matrix metalloproteinases, intercellular communicationsCorneal epithelium-transport and permeabilityStem cells of the ocular surfaceThe ocular surface-the surgical treatment for corneal epithelial stem cell deficiency, corneal epithelial defects, and periferal corneal ulcerRefractive surgeryRefractive surgery and inlaysContact lensesImaging of the corneaThe corneal stromaCorneal dystrophiesCorneal imaging-clinicalCorneal scarsCorneal endothelium-overviewRegulation of corneal endothelial functionRegulation of corneal endothelial cell proliferationArtificial corneaDrug delivery to cornea and conjunctiva-esterase- and protease-directed prodrug designKnock-out mice models: cornea, conjunctiva, eyelids, and lacrimal glandsGene therapyIII. Immune Regulation of the Cornea and Conjunctiva and Its Dysregulation in DiseaseAdaptive Immune System and the Eye: Mucosal ImmunityAdaptive immune system and the eye: T-cell mediated immunityInnate immune system and the eyeImmunoregulatory processes that sustain immune privilege in the eyeImmunosupressive and anti-inflammatory molecules that maintain immune previlege of the eyeAntigen-presenting cells in the eye and ocular surfaceDry eye: An immune-based inflammationPenetrating keratoplastyImmunopathogenesis of HSV KeratitisImmunopathogenesis of Onchocerciasis (River Blindness)Immunopathogenesis of pseudomonas keratitisImmunobiology of acanthomeba karatitisMolecular and cellular mechanisms in allergic conjunctivitisPathogenesis of fungal keratitisConjunctiva Immune surveillanceDefense mechanisms of tears and ocular surfaceCorneal epithelium- response to infectionInflammation of the ConjunctivaConcept of Angiogenic PrivilegeCorneal angiogenesisAvascularity of the corneaIV. Visual Acuity Related to the Cornea and Its DisordersVisual optics: pupilAcuityContrast sensitivityAstigmatismVera-Diaz- MyopiaLevi-AmblyopiaHarb- Hyperopia