The Mouse in Biomedical Research

Prof. James G. Fox obtained his Doctor of Veterinary Medicine at Colorado State University, Fort Collins, and, as an NIH postdoctoral fellow, received a Master of Science in Medical Microbiology at Stanford University. Dr. Fox is an adjunct professor at Tufts University School of Veterinary Medicine. He is a diplomate and a past president of the American College of Laboratory Animal Medicine, as well as a past president of the Massachusetts Society for Medical Research and the American Association of Veterinary Medical Colleges. Additionally, he has served as past chairman of the AAALAC Council and the NCCR/NIH Comparative Medicine Study Section. He is also an elected fellow of the Infectious Disease Society of America and the American Gastroenterological Association. He was recruited to MIT and created the Division of Comparative Medicine, which he directed from 1974 until 2021. As a faculty member in the MIT Department of Biological Engineering, Professor Fox received numerous scientific awards and was elected to the National Academy of Medicine in 2004. Dr. Fox has been the principal investigator of an NIH postdoctoral training grant for veterinarians for 30 years and has trained 90 veterinarians for careers in biomedical research. The NIH has continuously funded him to study infectious diseases of the gastrointestinal tract, where he has studied the gastrointestinal microbiome and how it interfaces with and influences the host’s immune response to gastrointestinal pathogens, particularly oncogenic Helicobacter species. He has authored over 600 papers, 84 chapters, holds 4 patents and has authored or edited 18 comparative medicine texts.

• Viral DiseasesDNA Viruses1. Mouse Cytomegalovirus and other Herpesviruses2. Mouse Adenoviruses3. Mousepox4. Parvoviruses5. Polyoma VirusesRNA Viruses6. Mouse Hepatitis Virus7. Lymphocytic Choriomeningitis Virus8. Lactate Dehydrogenase-Elevating Virus9. Reoviridae10. Retroelements in the Mouse11. Sendai Virus and Pneumonia Virus of Mice (PVM)12. Cardioviruses: Encephalomyocarditis Virus and Theiler's Mouse Encephalomyelitis VirusBacterial Diseases13. Chlamydial Diseases14. Clostridial Species15. Enterobacteriaceae, Pseudomonas aeruginosa, and Streptobacillus moniliformis16. Aerobic Gram-positive Organisms17. Helicobacter Infections in Mice18. Mycoplasma pulmonis, Other Mouse Mycoplasmas, and Cilia-Associated Respiratory Bacillus19. PasteurellaceaeMycotic and Parasitic Diseases20. Fungal Diseases in Laboratory Mice21. Protozoa22. Helminth Parasites of Laboratory Mice23. ArthropodsMiscellaneous Diseases24. The Tumor Pathology of Genetically Engineered Mice: A New Approach to Molecular Pathology25. Spontaneous Diseases in Commonly Used Mouse Strains26. Zoonoses and Other Human Health Hazards