The Mouse in Biomedical Research

Prof. James G. Fox obtained his Doctor of Veterinary Medicine at Colorado State University, Fort Collins, and, as an NIH postdoctoral fellow, received a Master of Science in Medical Microbiology at Stanford University. Dr. Fox is an adjunct professor at Tufts University School of Veterinary Medicine. He is a diplomate and a past president of the American College of Laboratory Animal Medicine, as well as a past president of the Massachusetts Society for Medical Research and the American Association of Veterinary Medical Colleges. Additionally, he has served as past chairman of the AAALAC Council and the NCCR/NIH Comparative Medicine Study Section. He is also an elected fellow of the Infectious Disease Society of America and the American Gastroenterological Association. He was recruited to MIT and created the Division of Comparative Medicine, which he directed from 1974 until 2021. As a faculty member in the MIT Department of Biological Engineering, Professor Fox received numerous scientific awards and was elected to the National Academy of Medicine in 2004. Dr. Fox has been the principal investigator of an NIH postdoctoral training grant for veterinarians for 30 years and has trained 90 veterinarians for careers in biomedical research. The NIH has continuously funded him to study infectious diseases of the gastrointestinal tract, where he has studied the gastrointestinal microbiome and how it interfaces with and influences the host’s immune response to gastrointestinal pathogens, particularly oncogenic Helicobacter species. He has authored over 600 papers, 84 chapters, holds 4 patents and has authored or edited 18 comparative medicine texts.

• 1. The Molecular Basis of Lymphoid Architecture in the Mouse2. The Biology of Toll-like Receptors in Mice3. Genomic Organization of the Mouse Major Histocompatibility Complex4. Some Biological Features of Dendritic Cells in the Mouse5. Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch Recombination of Immunoglobulin Genes6. Mouse Natural Killer Cells: Function and Activation7. Cytokine-activated JAK-STAT Signaling in the Mouse Immune System8. Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse9. Mouse Models of Negative Selection10. Peripheral Tolerance of T Cells in the Mouse11. The Genetics of Mouse Models of Systemic Lupus12. Inhibitory Receptors and Autoimmunity in the Mouse13. Mouse Models of Immunodeficiency14. Mouse Models to Study the Pathogenesis of Allergic Asthma15. The Mouse Trap: How Well Do Mice Model Human Immunology?