Principles of Behavioral Genetics

Robert R.H. Anholt works in the W.M. Keck Center for Behavioral Biology at North Carolina State University, Raleigh, NC, USA

• PrefaceChapter 1: Introduction and Historical PerspectiveOverviewThe Rise of the Modern Field of Behavioral GeneticsThe Modern Evolutionary SynthesisThe Rise of Molecular GeneticsA Brief History of NeuroscienceThe Emergence of Behavioral GeneticsSummaryStudy QuestionsRecommended ReadingChapter 2: Mechanisms of Neural CommunicationOverviewTransmission of Information in the Nervous SystemThe Resting Membrane PotentialThe Mechanism of the Action PotentialIon Channels, G-protein-coupled Receptors, and Signal TransductionSummaryStudy QuestionsRecommended ReadingChapter 3: Functional Organization of the Nervous SystemOverviewThe Organization of the Mammalian Nervous SystemCommunication between the Brain and the PeripheryOrganization of the Nervous System in InsectsNeurotransmittersSummaryStudy QuestionsRecommended ReadingChapter 4: Measuring Behavior: Sources of Genetic and Environmental VariationOverviewBehavioral AssaysControlling Experimental VariationSources of Variation in BehaviorEffects of Mutations on Behavioral PhenotypesEnvironmental VariationGene – Environment Correlation and InteractionSummaryStudy QuestionsRecommended ReadingChapter 5: Mapping Genotype to Phenotype in PopulationsOverviewGenes in Populations: Random MatingGenes in Populations: InbreedingQuantitative Genetic ModelSummaryStudy QuestionsRecommended ReadingChapter 6: Partitioning Phenotypic Variance and HeritabilityOverviewComponents of Variance in Random Mating PopulationsGenotype–Environment Correlation and InteractionPartitioning Phenotypic VarianceHeritability : The ConceptControlling and Estimating Environmental Components of VariationSummaryStudy QuestionsRecommended ReadingChapter 7: Estimating HeritabilityOverviewPhenotypic Resemblance between RelativesGenetic Causes of Covariance between RelativesEnvironmental Causes of the Relationship between RelativesHeritability Estimates in HumansHeritability in Other PopulationsEstimates of Heritability for Behavioral TraitsSummaryStudy QuestionsRecommended ReadingChapter 8: Quantitative Trait Locus MappingOverviewLinkage MappingInterval MappingStatistical AnalysisAssociation MappingQuantitative Trait Locus End GameSummaryStudy QuestionsRecommended ReadingChapter 9: Mutagenesis and TransgenesisOverviewThe Occurrence or Induction of MutationsHomologous RecombinationTransposon -mediated MutagenesisThe GAL4-UAS Binary Expression System in DrosophilaRNA InterferenceSummaryStudy QuestionsRecommended ReadingChapter 10: Genomics Approaches in Behavioral GeneticsOverviewDetecting Large-scale Gene ExpressionParallel Sequencing and Transcriptional AnalysisPlasticity of Transcriptional ProfilesAnalysis of Whole-genome Expression MicroarrayDefining Statistical Signifi cance ThresholdIdentifying Genetic NetworksSummaryStudy QuestionsRecommended ReadingChapter 11: Neurogenetics of Activity and SleepOverviewLocomotionGenetics of Human Locomotion DisordersCircadian RhythmsSleepSummaryStudy QuestionsRecommended ReadingChapter 12: Genetics of Social InteractionsOverviewSocial Environment and the Genes–Brain–Behavior ParadigmSocial Cooperation and FitnessCourtship and Mate SelectionAffiliative BehaviorAggression and the Establishment of Social HierarchiesDivision of Labor: The Genetics of Social StructureAggregation BehaviorSummaryStudy QuestionsRecommended ReadingChapter 13: Genetics of Olfaction and TasteOverviewThe Study of OlfactionThe Discovery of Odorant ReceptorsTransgenic Approaches to Determine Odorant Receptor Response ProfilesTransgenic Approaches to Map Projection Patterns of Olfactory Sensory NeuronsThe Use of Transgenic Reporter Genes to Visualize Odor CodingTaste and Gustatory ReceptorsSummaryStudy QuestionsRecommended ReadingChapter 14: Learning and MemoryOverviewForming MemoriesMemory Formation: Cellular MechanismsHarnessing the Power of Genetics: Learning in DrosophilaIdentifying Genetic Networks for Learning and MemoryLearning DisabilitiesNeurodegeneration and Memory Impairment: Alzheimer’s DiseaseSummaryStudy QuestionsRecommended ReadingChapter 15: Genetics of AddictionOverviewHallmarks of AddictionAlcoholismLinkage and Association StudiesAlcohol Sensitivity in Model OrganismsAlcohol-related Phenotypes in Rodent ModelsSmokingDrug AddictionSummaryStudy QuestionsRecommended ReadingChapter 16: Evolution of BehaviorOverviewPopulation Genetics and EvolutionModels of EvolutionSelection ModelsAssessing Deviations from NeutralityBehavior as a Vehicle for EvolutionInsect–Host Plant Interactions: An Example of Evolutionary AdaptationCo-evolution of Sexual Communication SystemsStudy QuestionsRecommended ReadingChapter 16: Evolution of BehaviorOverviewPopulation Genetics and EvolutionModels of EvolutionSelection ModelsAssessing Deviations from NeutralityBehavior as a Vehicle for EvolutionInsect–Host Plant Interactions: An Example of Evolutionary AdaptationCo-evolution of Sexual Communication SystemsThe Evolutionary Genetics of Burrowing and Nest BuildingThe Astounding Diversity of Cichlids and SticklebacksUnderstanding the Evolution of Behavior: How Much Do We Really Know?SummaryStudy QuestionsRecommended ReadingGlossaryIndex