Ralph A. Bradshaw: University of California, San Francisco Professor of Chemistry and Pharmaceutical Chemistry and Deputy Director of the Mass Spectrometry Facility; also Professor Emeritus of the Dept of Physiology & Biophysics, UC Irvine Bradshaw is an emeritus member of the Board of Directors of the Keystone Symposia on Molecular and Cellular Biology and Co-editor of Molecular and Cellular Proteomics. His research interests are in the area of polypeptide growth factors and their receptors, cell signaling, N-terminal processing of proteins and proteomics. He has published over 300 articles in these and related areas. Edward A. Dennis: University of California, San Diego Distinguished Professor of Chemistry and Biochemistry and former Department Chair and Professor of Pharmacology in the School of Medicine, Dennis is currently Editor-in-Chief of the Journal of Lipid Research and Director of the LIPID MAPS initiative. He also served as Chair of the Board of Directors of the Keystone Symposia on Molecular and Cellular Biology and current as an Emeritus member of the Board of Directors. His current research focus is on phospholipases, cell signaling and lipidomics on which he has published over 300 papers, most related to signal transduction by lipid messengers