Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

"The series which all immunologists need."--THE PHARMACEUTICAL JOURNAL"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --SCIENCE"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --JOURNAL OF IMMUNOLOGICAL METHODS

• 1. IntroductionHugh McDevitt and Emil R. Unanue 2. TBCHarald von Boehmer and Elmar Jaeckel3. TBCLucienne Chatenoud4. TBCAke Lernmark5. UntitledDianne Mathis6. CD8+ T cells in Type 1 DiabetesPere Santamaria 7. Dysregulation of T cell Peripheral Tolerance in Type 1 DiabetesRoland Tisch8. Genetic Basis for Protection from Type 1 DiabetesLinda Wicker