Annual Reports in Medicinal Chemistry

Häftad, Engelska, 2009

Del 44 i serien Annual Reports in Medicinal Chemistry

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Beskrivning

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

Covers findings related to cardiovascular, inflammation, and pulmonary diseases
Examines issues in oncology, from mTor inhibitors to drug targets
Incorporates up-to-date information on drug design and discovery, including delivery to market

Produktinformation

Utgivningsdatum:2009-12-21
Mått:152 x 229 x undefined mm
Vikt:1 200 g
Format:Häftad
Språk:Engelska
Serie:Annual Reports in Medicinal Chemistry
Antal sidor:736
Förlag:Elsevier Science
ISBN:9780123747662

Utforska kategorier

Innehållsförteckning

1 Recent advances in the discovery of GSK-3 inhibitors and aperspective on their utility for the treatment of Alzheimer’sdiseaseRobert G. Gentles, Shuanghua Hu,and. Gene Dubowchik2 Advances in the Development of Nitric Oxide Synthase InhibitorsShawn Maddaford, SubhashAnnendi, Jailall Remnauth, andSuman Rakhit3 Small Molecule Protein–Protein Interaction Inhibitors asTherapeutic Agents for Neurodegenerative Diseases: CurrentProgress and Future HurdlesSimon Haydar and Warren Hirst 4 Case History: Chantix (varenicline tartrate) a Nicotinic PartialAgonist Aid to Smoking CessationJotham W. Coe, Hans Rollema andBrian T. O’Neill 5 Case History on Tekturna® /Rasilez® (Aliskiren), a HighlyEfficacious Direct Oral Renin Inhibitor as a New Therapy forHypertensionJuergen Maibaum and David Feldman6 Advances in Vasopressin Receptor Agonists and Antagonists Thomas Ryckmans 7 The Emergence of GPR119 Agonists as Anti-diabetic Agents Robert Jones 8 Non-peptide Ligands for the Gonadotropin Receptors Nicole van Straten, Marco Timmers9 Recent Advances in Coagulation Serine Protease InhibitorsMimi Quan and Joanne Smallheer10 Advances in the Discovery of Anti-Inflammatory FMS Inhibitors Mark Player and Carl Manthey11 Recent Advances in the Discovery of CB2 Selective Agonists Jayant Thatte, Sangdon Han, and Rob Jones 12 Advances in the Discovery of Small Molecule JAK3 Inhibitors Stephen Wrobleski 13 Recent Advances in Adenosine Receptor (AR) Ligands inPulmonary DiseasesJeff Zablocki and Rao Kalla 14 Recent Progress in the Development of Small Molecule Inhibitorsof Insulin-like Growth Factor Receptor (IGF-1R) Kinase Dinesh Vyas and Mark Wittman 15 Case History: Discovery of Ixabepilone (IXEMPRA[TM]), a First-inclassEpothilone Analogue for Treatment of Metastatic Breast CancerRobert M. Borzilleri and Gregory D.16 Hedgehog Signaling Pathway Inhibitors as Cancer Therapeutics Stefan Peuker and Karen Miller-Moslin 17 Emerging Therapies Based on Inhibitors of Phosphatidyl-Inositol-3-Kinases (PI3Ks)John M. Nuss, Amy Lew Tsuhakoand Neel K. Anand Exelixis18 Anti-infective Activity of Artemisinin and its Semi-syntheticDerivatives John G. D'Angelo19 Recent Advances in the Inhibition of Bacterial Type IITopoisomerasesGreg Bisacchi & Jacques Dumas20 Progress Towards the Discovery and Development of SpecificallyTargeted Inhibitors of Hepatitis C VirusNicholas A. Meanwell John F.Kadow and Paul M. Scol 21 Inhibitors of Nuclear Hormone Receptor/Steroid ReceptorCoactivator InteractionsTerry Moore, John Katzenellenbogen 22 Safety Testing of Drug Metabolites Tom Thompson 23 A Path to Innovation: Gene Knockouts Model New Drug Action Brian Zambrowicz 24 Discovery of Novel Positron Emission Tomography (PET) Tracers Dennis McCarthy 25 The Use of Isotopically Labeled Compounds in Drug Discovery (Chad) Charles S. Elmore26 Mechanism based inhibition of CYP3A4 and other cytochromes P450 Bernard Murray 27 Nonclinical Toxicogenomics in the Pharmaceutical Environment Bruce D. Car 28 To Market, To Market 2008 Shridhar Hegde and Michelle Schmidt