The Zebrafish: Disease Models and Chemical Screens

Professor of Biochemistry and Marine Biology at Northeastern University, promoted 1996. Joined Northeastern faculty in 1987. Previously a faculty member in Dept. of Biochemistry at the University of Mississippi Medical Center, 1983-1987.Principal Investigator in the U.S. Antarctic Program since 1984. Twelve field seasons "on the ice" since 1981. Research conducted at Palmer Station, Antarctica, and McMurdo Station, Antarctica.Research areas: Biochemical, cellular, and physiological adaptation to low and high temperatures. Structure and function of cytoplasmic microtubules and microtubule-dependent motors from cold-adapted Antarctic fishes. Regulation of tubulin and globin gene expression in zebrafish and Antarctic fishes. Role of microtubules in morphogenesis of the zebrafish embryo. Developmental hemapoiesis in zebrafish and Antarctic fishes. UV-induced DNA damage and repair in Antarctic marine organisms.

• Part I: Disease Models1. Germ Cell Tumors in Zebrafish2. Schwann Cell Myelination Mutants as Models of Multiple Sclerosis3. In Vivo Analysis of Zebrafish Adipogenesis4. Host-Microbe Interactions in the Zebrafish5. Hematopoietic Stem Cell Development and Blood Flow6. Zebrafish as a Model for Hemorrhagic Stroke7. Zebrafish Adaptive Immunity: Structure and Function of Physiologic Development and Malignant Transformation8. Zebrafish VHL Disease Model9. Muscle Diseases10. Basement Membrane Diseases11. Lymphangiogenesi12. Osteogenesis13. Zebrafish Assays of Ciliopathies14. Infectious Disease: Innate Immunity15. Tuberculosis16. Cancer17. Melanoma18. Pancreatic Cancer19. Rhabdomyosarcoma20. Transplantation in Zebrafish21. Modeling Human Disease by Gene Targeting 22. Fluorescent Imaging of Cancer23. Zebrafish as a Model for Fanconi’s AnemiaPart II: Chemical Screens24. Chemical Screens for Potential Therapeutics25. Psychotropic Drug Discovery by Automated Behavioral Phenotyping26. Discovery and Use of Small Molecules for Probing Biological Processes