Modifications of Nuclear DNA and its Regulatory Proteins

PRAISE FOR THE SERIES "Full of interest not only for the molecular biologist--for whom the numerous references will be invaluable--but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal

• 1. Introduction – Epiphanies in EpigeneticsXiaodong Cheng and Robert M. BlumenthalSection I. EVOLUTION OF DNA METHYLATION2. The natural history of eukaryotic DNA methylation systemsLakshminarayan M. Iyer, Saraswathi Abhiman, L. Aravind3. Evolution of histone methyltransferases and demethylasesL. Aravind4. DNA methylation in Drosophila – A critical evaluationVeiko Krauss and Gunter Reuter5. DNA Methylation in ZebrafishMary G Goll and Marnie E HalpernSeciton II. MAMMALIAN DNA METHYLTRANSFERASES – STRUCTURE AND FUNCTION6. Dnmt1 - structure and functionŽeljko M. Svedružić7. The DNMT3 family of MAMMALIAN de novo DNA methyltransferasesFrédéric ChédinSeciton III. DNA METHYLATION AND DEMETHYLATION8. Recruitment of Dnmt1: Roles of the SRA protein Np95 (Uhrf1) and other factorsJafar Sharif & Haruhiko Koseki9. Regulation of Expression and Activity of DNA (cytosine-5) methyltransferases in mammalian cellsShannon R. Morey Kinney and Sriharsa Pradhan10. Mechanistic and functional links between histone methylation and DNA methylationTaiping ChenSection IV. DNA METHYLATION IN MEDICINE11. RNA mediated silencing mechanisms in mammalian cellsAnton Wutz12. Biological functions of methyl-CpG binding proteinsPierre-Antoine Defossez and Irina StanchevaSection V. DNA METHYLATION IN MEDICINE13. Diseases associated with imprintingJ.F. Wilkins and F. Úbeda14. DNA methylation changes in cancerMinoru Toyota and Eiichiro Yamamoto15. Epigenetic biomarkersJ. Tost16. Distribution of methylation at the single-nucleotide levelE.