Structural and Mechanistic Enzymology

Bringing Together Experiments and Computing

Inbunden, Engelska, 2012

Del 87 i serien Advances in Protein Chemistry and Structural Biology

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Beskrivning

Both strategies for investigation (computational and experimental) in structural and mechanistic Enzymology have developed to some extent independently. However, over the last few years a trend has emerged for strengthening their integration. This combination not only brings together computations and experiments focused on the same enzymatic problems, but also provides complementary insights into the investigated properties and has a powerful synergy effect. This thematic volume of Advances in Protein Chemistry and Structural Biology focuses on the recent success in structural and mechanistic enzymology and has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches. The selected contributions demonstrate how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design.

Focuses on the recent success in structural and mechanistic enzymology
Has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches
Demonstrates how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design

Produktinformation

Utgivningsdatum:2012-07-07
Mått:152 x 229 x 25 mm
Vikt:900 g
Format:Inbunden
Språk:Engelska
Serie:Advances in Protein Chemistry and Structural Biology
Antal sidor:472
Förlag:Elsevier Science
ISBN:9780123983121

Utforska kategorier

Biokemi inom Naturvetenskap och teknik
Biologi inom Naturvetenskap och teknik

Mer om författaren

Dr. Christo Z. Christov teaches at Northumbria University, Ellison Building, Newcastle-upon-Tyne, UK Dr. Tatyana Karabencheva-Christova works at the Department of Applied Sciences, University of Northumbria, UK.

Innehållsförteckning

Structural and Computational Enzymology: Bringing Experiments and Computations TogetherTatyana Karabencheva and Christo ChristovStructural and Functional Analysis of Proteins by High-Speed Atomic Force MicroscopyArivazhagan Rajendran, Masayuki Endo and Hiroshi SugiyamaReaction Intermediates Discovered in Crystal Structures of EnzymesIrene T. Weber, Johnson Agniswamy, Guoxing Fu, Chen-Hsiang Shen and Robert W. HarrisonStructural, Functional and Mutagenesis Studies of UDP-GlycosyltransferasesVatsala Malik and Gary W BlackVipoxin and its Components: Structure – Function RelationshipS. D. Petrova, V. N. Atanasov and K. BalashevExperimental and Theoretical Studies of Enzyme-Catalyzed Hydrogen Transfer ReactionsZhen Wang, Daniel Roston and Amnon KohenProtein Flexibility and Enzymatic CatalysisM. Kokkinidis, N. M. Glykos and V. E. FadouloglouMolecular Modeling of Inhibitors of Human DNA Methyltransferase with a Crystal Structure: Discovery of a Novel DNMT1 InhibitorJakyung Yoo, Joo Hee Kim, Keith D. Robertson and José L. Medina-FrancoIn Silico Strategies Towards Enzyme Function and DynamicsSílvia G. EstácioDynamic Simulations as a Complement to Experimental Studies of Enzyme MechanismsAndrew Christofferon, Lifeng Zhao and Qiang PeiThe Increasing Role of QM/MM in Drug DiscoveryAlessio Lodola and Marco De VivoProbing Allostery and Binding Cooperativity of the Catalytic Subunit of Protein Kinase A by NMR Spectroscopy and Molecular Dynamics SimulationsLarry R. Masterson, Alessandro Cembran, Lei Shi and Gianluigi VegliaUsing a Combination of Computational and Experimental Techniques to Understand the Molecular Basis for Protein AllosteryWanting Jiao and Emily J. Parker