Structural and Mechanistic Enzymology

Dr. Christo Z. Christov teaches at Northumbria University, Ellison Building, Newcastle-upon-Tyne, UK Dr. Tatyana Karabencheva-Christova works at the Department of Applied Sciences, University of Northumbria, UK.

• Structural and Computational Enzymology: Bringing Experiments and Computations TogetherTatyana Karabencheva and Christo ChristovStructural and Functional Analysis of Proteins by High-Speed Atomic Force MicroscopyArivazhagan Rajendran, Masayuki Endo and Hiroshi SugiyamaReaction Intermediates Discovered in Crystal Structures of EnzymesIrene T. Weber, Johnson Agniswamy, Guoxing Fu, Chen-Hsiang Shen and Robert W. HarrisonStructural, Functional and Mutagenesis Studies of UDP-GlycosyltransferasesVatsala Malik and Gary W BlackVipoxin and its Components: Structure – Function RelationshipS. D. Petrova, V. N. Atanasov and K. BalashevExperimental and Theoretical Studies of Enzyme-Catalyzed Hydrogen Transfer ReactionsZhen Wang, Daniel Roston and Amnon KohenProtein Flexibility and Enzymatic CatalysisM. Kokkinidis, N. M. Glykos and V. E. FadouloglouMolecular Modeling of Inhibitors of Human DNA Methyltransferase with a Crystal Structure: Discovery of a Novel DNMT1 InhibitorJakyung Yoo, Joo Hee Kim, Keith D. Robertson and José L. Medina-FrancoIn Silico Strategies Towards Enzyme Function and DynamicsSílvia G. EstácioDynamic Simulations as a Complement to Experimental Studies of Enzyme MechanismsAndrew Christofferon, Lifeng Zhao and Qiang PeiThe Increasing Role of QM/MM in Drug DiscoveryAlessio Lodola and Marco De VivoProbing Allostery and Binding Cooperativity of the Catalytic Subunit of Protein Kinase A by NMR Spectroscopy and Molecular Dynamics SimulationsLarry R. Masterson, Alessandro Cembran, Lei Shi and Gianluigi VegliaUsing a Combination of Computational and Experimental Techniques to Understand the Molecular Basis for Protein AllosteryWanting Jiao and Emily J. Parker