Principles of Developmental Genetics

Sally A. Moody is Professor of Anatomy and Cell Biology at the George Washington University Medical Center, and a member of both the Neuroscience and Genetics programs. Prior to this appointment she was on the faculty of the Anatomy and Cell Biology Department, the Department of Neuroscience, and the Developmental Biology program at the University of Virginia. She trained in developmental neurobiology at the University of Florida’s Department of Neuroscience and the University of Utah’s Department of Neurobiology and Anatomy. Dr. Moody’s current research focuses on the cascade of interactions that instruct lineages to give rise to the frog nervous system. She has taught developmental neurobiology in the MBL "Neurobiology" course and was co-director of the "Early Development of Xenopus Laevis" course at the Cold Spring Harbor Laboratory. She has also served on many National Institute of Health advisory committees dealing with issues in developmental biology and developmental neurobiology, and served on the Board of Trustees of the Society for Developmental Biology.

"...expert coverage of all major events in early embryogenesis and the organogenesis of specific systems, supplemented with representative clinical syndromes." --Anticancer Research

• Section I: Emerging Technologies and Systems Biology1. Untangling the Gordian knot: Cell signaling events that instruct development2. RNA-seq and deep sequencing3. Using mutagenesis in mice and zebrafish for developmental gene discovery4. Chemical approaches to control stem cell fate5. BMP signaling and stem cell self-renewal in the Drosophila ovary6. Genomic Analyses of Neural Stem Cells7. Chordate origins, stem cells and regenerationSection II: Early Embryology and Morphogenesis8. Dorsal-ventral axis patterning in insects 9. Building dimorphic forms: an examination of the genetic pathways that intersect embryonic patterning and sex determination10. Anterior-Posterior patterning in mammals11. Early development of epidermis and neural tissue12. Taking the middle road: mesoderm induction and the blastula-gastrula transition13. Endoderm induction14. Epithelial branching: mechanisms of patterning and self-organization15. Lateral line migrationSection III: Organogenesis16. Neural cell fate determination17. Retinal development18. Neural crest determination19. Determination of preplacodal ectoderm and sensory placodes20. Olfactory development21. Inner ear development22. Molecular genetics of tooth development23. Induction of the cardiac lineages 24. Blood vessel formation25. Blood induction and embryonic formation26. Vertebrate kidney formation: a comparative perspective27. Development of the genital system28. Skeletal  development29. Formation of vertebrate limbs30. Patterning the embryonic endoderm into presumptive organ domains31. Pancreas Development and RegenerationSection IV: Selected Clinical Problems32. Diaphragmatic embryogenesis and human congenital diaphragmatic defects33. Genetic and developmental basis of congenital cardiovascular malformations34. Multiple Roles of T-box genes35. Craniofacial syndromes: etiology, impact and treatment36. DeGeorge and related syndromes37. Neural tube defects