Molecular Basis of Nutrition and Aging

Dr. Marco Malavolta started his career as a chemist with a PhD in Nutrition and Health at the University of Ancona, but then focused his research activity specifically in biogerontology research. He has been working in this field for the last 10 years with a particular focus on the role of trace elements and other micronutrients in aging. Currently, Dr. Malavolta is involved in the identification of nutritional factors that are able to modulate cellular senescence or that can be used to selectively remove accumulating senescent cells in aged organisms. He is convinced of the existence of a causal relationship between aging and age-related diseases, and that the key to develop effective interventions for these diseases lies in the deep understanding of the biological aging process. Dr. Malavolta is author or co-author of more than 100 peer-reviewed articles in the field of nutrition and biogerontology. Additionally, he is also a member of the editorial boards of several journals dedicated to these thematic areas. Most of his research activity has been carried out and is currently conducted in the Centre of Nutrition and Ageing at INRCA, The Italian National Institute of Health and Science on Aging. Dr. Eugenio Mocchegiani has 40 years expertise as researcher at INRCA, The Italian National Institute of Health and Science on Aging. For the past 10 years, he has been the Head of the Centre of Nutrition and Aging at INRCA. His field of research concerns the role of endocrine and nutritional factors in immunosenescence, tumurs, infectious diseases, metabolic diseases and dementia. More specifically, he has contributed to advance knowledge on zinc binding proteins as genetic and biological markers of aging. Dr. Mocchegiani has received several grants from the Italian Ministry of Health for studies around micronutrients and aging. Additionally, he was coordinator of the EU Project ZINCAGE in the FP6 program, and as Operative Unit in the EU project MARK-AGE in the FP7 program. Dr. Mocchegiani has authored or co-authored more than 200 peer-reviewed articles in the field of nutrition and gerontology and is a member of the editorial board of several journals dedicated to these thematic areas.

• Part 1: Introductory aspects on aging and nutrition1. Molecular and Cellular Basis of Aging2. Unraveling stochastic aging processes in mouse liver: dissecting biological from chronological age 3. Nutrigenomics and Nutrigenetics: the basis of molecular nutrition4. Diet and Longevity Phenotype5. Nutrition in the elderly: general aspects6. Nutrition in the hospitalized elderly7. Drug-nutrient interactions in the elderly8. Nutritional Biomarkers of Aging9. Food preferences in aging: molecular basisPart 2: Molecular and cellular targets10. Telomeres, Nutrition and Aging11. MTOR, Nutrition and Aging12. Lipid Peroxidation, Diet and Aging13. Accumulation of Damage Due to Lifelong Exposure to Environmental Pollution as Dietary Target in Ageing14. Nutritional impact on anabolic and catabolic signaling15. Aging and dietary modulation of FoxO1 phosphorylation/acetylation16. Epigenetic responses to diet in ageing17. The controversy around sirtuins and their functions in aging18. DNA damage, DNA repair and Nutrition in Aging19. Neuroprotective Mechanisms of Dietary Phytochemicals: Implications For Successful Brain Aging20. Nutritional modulation of Advanced Glycation End-Products21. miRNAs as Nutritional Targets in Aging22. Nutritional modulators of cellular senescencePart 3: System and organ targets 23. Nutrition, diet quality and cardiovascular health24. Nutrition and the Basis of Cognitive Aging and Dementia25. Dietary factors affecting osteoporosis and bone health in elderly26. The aging muscle and Sarcopenia: interaction with diet and nutrition27. Nutritional status and gastrointestinal health in elderly28. How nutritional status can affect the immune system in the elderly29. Glucose Metabolism, Insulin and Aging: Role of Nutrition30. Nutritional status in ageing and lung disease31. How nutrition affects kidney function in aging32. Role of nutrition in visual function in agingPart 4: Health effects of dietary compounds and dietary interventions 33. Vitamin D-gene interaction and healthful aging34. Carotenoid supplements and consumption: implications for healthy aging35. Curcumin mechanisms and applications in aging36. One-carbon metabolism: an unsung hero for healthy aging37. Iron Metabolism in Aging38. Dietary Mineral Intake (potassium, calcium and magnesium) and the biological processes of aging39. Zinc: an essential trace element for the elderly40. Selenium deficiency, interventions and the risk of diseases of aging41. Iodine intake and healthy aging42. Vitamin B status and health in aging43. Vitamin C intake and antioxidant status and the diseases of aging44. Omega 3 fatty acids in aging45. Vitamin E, inflammatory/immune response and the elderly 46. Mechanisms and effects of Polyphenols in aging47. Potential of Asian natural products for health in aging48. Caloric restriction in humans: impact on health 49. Prebiotics and Probiotics in aging population: Effects on the immune-gut microbiota axis50. Vegetables and fruit in the prevention of chronic age-related diseases51. Current Nutritional Recommendations: elderly versus earlier stage of life