Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies.

This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease.

Provides a comprehensive introduction to collagen and structural proteins
Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation
Includes a chapter dedicated to the biomarkers of structural proteins
Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states

Produktinformation

Utgivningsdatum:2016-08-26
Mått:152 x 229 x 15 mm
Vikt:430 g
Format:Häftad
Språk:Engelska
Antal sidor:272
Förlag:Elsevier Science
ISBN:9780128098479

Utforska kategorier

Biovetenskap inom Naturvetenskap och teknik
Biologi inom Naturvetenskap och teknik

Mer om författaren

Morten Karsdal has been CEO of Nordic Bioscience A/S since June 2010. Since 2002, Morten Karsdal has focused his research on the discovery and development of novel biochemical markers. This has resulted in the development of more than 15 ELISA assays for detecting biomarkers that have been used for research in the fields of fibrosis, osteoporosis and osteoarthritis. One of these assays has been 510(k) approved by the Food and Drug Administration (FDA) in the USA.

Innehållsförteckning

Chapter 1. Type I CollagenChapter 2. Type II CollagenChapter 3. Type III CollagenChapter 4. Type IV CollagenChapter 5. Type V CollagenChapter 6. Type VI CollagenChapter 7. Type VII CollagenChapter 8. Type VIII CollagenChapter 9. Type IX CollagenChapter 10. Type X CollagenChapter 11. Type XI CollagenChapter 12. Type XII CollagenChapter 13. Type XIII CollagenChapter 14. Type XIV CollagenChapter 15. Type XV CollagenChapter 16. Type XVI CollagenChapter 17. Type XVII CollagenChapter 18. Type XVIII CollagenChapter 19. Type XIX CollagenChapter 20. Type XX CollagenChapter 21. Type XXI CollagenChapter 22. Type XXII CollagenChapter 23. Type XXIII CollagenChapter 24. Type XXIV CollagenChapter 25. Type XXV CollagenChapter 26. Type XXVI CollagenChapter 27. Type XXVII CollagenChapter 28. Type XXVIII CollagenChapter 29. LamininsChapter 30. ElastinChapter 31. Structural Biomarkers

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