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    1. Naturvetenskap och teknik
    2. Matematik och naturvetenskap
    3. Biologi
    4. Biovetenskap

    Epigenetics in Human Disease

    AvTrygve O. Tollefsbol

    Inbunden, Engelska, 2018

    Del i serien Translational Epigenetics

    1 709 kr

    Beställningsvara. Skickas inom 10-15 vardagar. Fri frakt över 249 kr.

    Beskrivning

    Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, and epigenetic mechanisms of imprinting disorders.

    Further sections explore online epigenetic tools and datasets, early-life programming of epigenetics in age-related diseases, the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer's disease, respiratory diseases, and many other human maladies.



    • Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applications
    • Integrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughs
    • Presents side-by-side coverage of the basis of epigenetic diseases and treatment pathways
    • Provides a fully revised resource covering current developments, including stem cell epigenetic therapy, the bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, online epigenetic tools and datasets, and more

    Produktinformation

    • Utgivningsdatum:2018-05-18
    • Mått:191 x 235 x 57 mm
    • Vikt:2 450 g
    • Format:Inbunden
    • Språk:Engelska
    • Serie:Translational Epigenetics
    • Antal sidor:1 110
    • Upplaga:2
    • Förlag:Elsevier Science
    • ISBN:9780128122150

    Utforska kategorier

    • Biovetenskap inom Naturvetenskap och teknik

    Mer om författaren

    Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist in the Spotlight by ScienceNow. He is an Associate Editor for Frontiers in Genetics, a contributor to Lewin’s GENES classic textbook and Lead Editor for Elsevier’s Translational Epigenetics Series. Dr. Tollefsbol has been named a “Highly Ranked Scholar” worldwide (ScholarGPS). He has been invited for numerous endowed keynote presentations, his research has been highlighted in eScience News and ScienceDaily and he has published 20 scholarly books on topics related to his research.

    Innehållsförteckning

    • Section I: Introduction1. Epigenetics in Human DiseaseSection II: Methodology2. Methods and Strategies to Determine Epigenetic Variation in Human Disease3. Age Estimates Using DNA Methylation Patterns4.Bioinformatics of Epigenetic Data Generated from Next-generation SequencingSection III: Human Cancer5. DNA Methylation Alterations in Human Cancers6. Alterations of Histone Modifications in Cancer7. MicroRNA in Cancer8. Epigenetic Approaches to Cancer TherapySection lV: Neurological Disease9. Epigenomics in Neurobehavioral Disease10. Emerging Role of Epigenetics in Human Neurodevelopmental Disorders11. The Epigenetics of Alzheimer’s and Other Neurodegenerative Disease12. Epigenetic Modulation of Human Neurobiological DisorderSection V: Autoimmune Disease13. Epigenetic Basis of Autoimmune Disorders in Humans14. Approaches to Autoimmune Diseases Using Epigenetic TherapySection VI: Metabolic Disorders15. Epigenomic Factors in Human Obesity16. Epigenetic Approaches to Control Obesity17. Epigenetics of Diabetes in Humans18. The Potential of Epigenetic Compounds in Treating DiabetesSection VII: Other Disorders/Diseases19. Epigenetic Aberrations in Human Allergic Diseases20. Therapy of Airway Disease: Epigenetic Potential21. The Role of Epigenetics in Cardiovascular Disease22. Epigenetic Treatment Approaches to Cardiovascular Disease23. Epigenetics and Human Infectious Diseases24. Therapy of Infectious Diseases Using Epigenetic Approaches25. The Epigenetics of Endometriosis26. Epigenetic DNA Methylation in Endometrial Cancer27. Epigenetic Treatment Prospects of Gynecological and Reproductive DiseasesSection VIII: Development, Aging and Transgenerational Effects28. Epigenetics of Transgenerational Inheritance in Disease29. Epigenetic Mechanisms of Human Imprinting Disorders30. Therapeutic Approaches to Imprinting Diseases31. Stem Cell Epigenetics and Human Disease32. Non-coding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation: Implications for Stem Cell Therapy33. Aging and Disease: The Epigenetic Bridge34. Epigenetic Programming of Human Disease and AgingSection lV: Future Research35. Future Directions in the Epigenetics of Human Disease