The HDL Handbook

Biological Functions and Clinical Implications

Inbunden, Engelska, 2017

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Beskrivning

The HDL Handbook: Biological Functions and Clinical Implications, Third Edition, brings laboratory research in HDL from bench to bedside in a reference format for both researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular medicine, and pathophysiology of cardiovascular diseases. Information presented is valuable for the development of clinical trials with the aim of improvement of HDL-C levels and the prevention of cardiovascular events. Highlights of this new edition include the science underpinning HDL metabolism including information on HDL-C metabolism, gene expression, gene-bioactive compounds interaction, and post-translational modifications of gene expression of apo-lipoproteins.

Includes bench-to-bedside coverage of HDL with thorough coverage of basic science, genetics, epidemiology, and treatment
Updated to include information on oxidated HDL found in the capillary vessels of patients with diabetes mellitus and/or atherosclerosis
Presents the latest advances in HDL cholesterol research with international perspectives

Produktinformation

Utgivningsdatum:2017-02-22
Mått:152 x 229 x 21 mm
Vikt:660 g
Format:Inbunden
Språk:Engelska
Antal sidor:320
Upplaga:3
Förlag:Elsevier Science
ISBN:9780128125137

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Mer om författaren

Dr. Komoda is a visiting professor at Toho University School of Medicine in Japan. He has extensive expertise with research in alkaline phosphatase, amylase, and oxidized HDL. He co-operated the intestinal alkaline phosphatase at Washington University School of Medicine in St. Louis, Missouri. He is the recipient of the Kodama Memorial Award from Japanese Society of Electrophoresis.

Recensioner i media

"This book accomplishes its goal of bringing laboratory research from the bench to the bedside in a format that can be used by researchers and clinicians alike who are studying HDL cholesterol."--Doody's

Innehållsförteckning

1. Molecular Mechanisms of Hyperalphalipoproteinemia2. CETP Deficiency and Concerns in CETP Inhibitor Development3. Degenerated HDL and Its Clinical Implications4. HDL Apoprotein Mimetic Peptides as Antiinflammatory Molecules5. Reverse Cholesterol Transport in HDL Metabolism: Relevance to Atherosclerosis Progression and Cardiovascular Diseases6. Role of ATP-Binding Cassette Transporters A1 and G1 in Reverse Cholesterol Transport and Atherosclerosis7. Sphingosine-1-Phosphate and HDL Metabolism8. Role of SR-BI in HDL Metabolism9. Paraoxonase 1 and Its Clinical Relevance10. MicroRNA Regulation of HDL Homeostasis11. The Application of Proteomic Techniques in the Study of HDL Particle Characterization and Biomarker Discovery12. Therapies Targeting HDLc Levels and HDL Function