Neurobiology of Depression

João L. de Quevedo, MD, Ph.D., obtained his Medical Degree and completed residency training in Psychiatry, a fellowship in Psychopharmacology, and a Ph.D. in Biological Sciences (Biochemistry), all from the Federal University of Rio Grande do Sul, Porto Alegre, Brazil. He is the John S. Dunn Distinguished Professor at the Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth Houston). He also serves as Professor, Vice-Chair for Faculty Development and Outreach, Executive Director of the Center for Interventional Psychiatry, Chief of the Division of Interventional Psychiatry, Director of the Treatment-Resistant Depression Program, and Program Director of the Interventional Psychiatry Fellowship. Dr. Joao L. de Quevedo is an Associate Editor for Molecular Psychiatry, a Springer Nature journal.Research profiles:ResearcherID: E-5491-2013Scopus Author ID: 56971689500https://orcid.org/0000-0003-3114-6611André F Carvalho is associate professor at the Department of Psychiatry at the University of Toronto and a clinician scientist at the Centre for Addiction and Mental Health (CAMH). He was elected member of the board of councilors of the International Society of Bipolar Disorders (2016-2017) and the vice-chair of the section of private practice psychiatry of the World Psychiatric Association (2015-2017). He sits on the editorial board of several international peer-reviewed journals, including Psychotherapy and Psychosomatics, and has served as a peer reviewer for several leading journals and funding agencies. He is an expert in mood disorders, psychiatric epidemiology, and evidence-based mental health. Dr. Carvalho is a sought after speaker in several national and international meetings, and is the author of over 300 publications. Dr. Zarate completed his residency training in psychiatry at the Massachusetts Mental Health Center/Brockton VAMC division. He later completed a fellowship in Clinical Psychopharmacology at McLean Hospital of the Consolidated Department of Psychiatry, Harvard Medical School and remained on staff at McLean Hospital as the Director of the Bipolar and Psychotic Disorders Outpatient Services. From 1998 to 2000 Dr. Zarate was the Chief of the Bipolar and Psychotic Disorders Program at the University of Massachusetts Medical School. In 2001, he joined the Mood and Anxiety Disorders Program at NIMH. His achievements and awards include the Ethel-DuPont Warren Award and Livingston Awards, Consolidated Department of Psychiatry, Harvard Medical School; Outstanding Psychiatrist Research Award, Massachusetts Psychiatric Association; Program for Minority Research Training in Psychiatry, APA; the National Alliance for Research on Schizophrenia and Depression Young Investigator Award; National Alliance for Research on Schizophrenia and Depression Independent Investigator Award; the National Institutes of Health Director’s Award Scientific/Medical, the 2011 Brain & Behavior Research Foundation Award for Bipolar Mood Disorder Research, the 2013 National Institute of Health Director’s Award—Scientific/Medical Achievement and Mogens Schou Research Award: Bipolar Disorder and the Simon-Bolivar Award American Psychiatric Association; 2015 Ruth L. Kirschtein Mentoring Award NIH and the Astute Clinician Lecture Award, NIH; the 2019 ACNP Dolores Shockley Minority Mentoring Award; and in 2019 was promoted to NIH Distinguished Investigator, NIMH, NIH. Dr. Zarate is a fellow of the American College of Neuropsychopharmacology and member of the Society of Biological Psychiatry and the Society for Neuroscience. Dr. Zarate’s research focuses on the pathophysiology and development of novel therapeutics for treatment-resistant mood disorders as well as the study of biomarkers and neural correlates of treatment response.

• 1. The Classification of Depression: Embracing Phenotypic Heterogeneity in the Era of the RDoCElizabeth D. Ballard, Ioline D. Henter and Carlos A. Zarate, Jr.2. The Role of Environmental and Psychosocial Factors in DepressionGordon Parker3. Gene-Environment Interactions and Epigenetic Mechanisms in DepressionMagdalene C. Jawahar, Catherine G. Toben and Bernhard T. Baune4. Pathophysiology of Cognitive Impairment in DepressionChristopher R. Bowie, Melissa Milanovic and Tanya Tran5. Anhedonia in Depression: Mechanisms, Assessment, and TherapeuticsTheodore P. Beauchaine, Daniel N. Klein, Erin Knapton and Aimee Zisner6. The Neurotrophic Hypothesis of Depression Revisited: New Insights and Therapeutic ImplicationsMinal Jaggar, Sashaina E. Fanibunda, Shreya Ghosh, Ronald S. Duman and Vidita A. Vaidya8. Neuro-Immune Interactions in Depression: Mechanisms and Translational ImplicationsHelena M. Abelaira, Ritele H. Silva, Anelise S. Carlessi, João Quevedo and Gislaine Z. Réus9. The Hypothalamic-Pituitary-Adrenal Axis in Depression: Molecular Regulation, Pathophysiological Role, and Translational ImplicationsTheo Rein, Oliver Ambrée, Gabriel R. Fries, Virginie Rappeneau, Ulrike Schmidt and Chadi Touma10. Intracellular Signaling Pathways Implicated in the Pathophysiology of DepressionGislaine Z. Réus, Jaqueline S. Generoso, Ana Lúcia S. Rodrigues and João Quevedo11. The Long-Lasting Neurobiological Scars of Early-Life Stress: Implications for the Neurobiology of DepressionMousa Botros, Gabrielle Hodgins and Charles B. Nemeroff12. Molecular, Cellular, and Circuit Basis of Depression Susceptibility and ResilienceMing-Hu Han, Scott J. Russo and Eric J. Nestler13. More Than a Gut Feeling: Emerging Roles of the Microbiome in the Pathophysiology and Treatment of DepressionJane A. Foster14. Optogenetics: Illuminating the Neural Circuits of DepressionMuir J. and Bagot R.C.15. Mitochondrial Dysfunction and Oxidative Stress: Relevance to the Pathophysiology and Treatment of DepressionAdrian L. Lopresti16. Obesity and Depression: Shared Pathophysiology and Translational ImplicationsLison Huet, Ines Delgado, Bruno Aouizerate, Nathalie Castanon and Lucile Capuron17. Depression and Cardiovascular Risk: Epidemiology, Mechanisms, and ImplicationsJessica Hatch and Benjamin I. Goldstein18. Poststroke Depression: Pathophysiology and Treatment StrategiesYun-Ju Lai and Louise D. McCullough19. Is Depression Associated With Accelerated Aging? Mechanisms and ImplicationsDaniel Lindqvist, Naomi M. Simon and Owen M. Wolkowitz20. Relationship Between Complicated Grief and Depression: Relevance, Etiological Mechanisms, and ImplicationsNicole J. LeBlanc, Naomi M. Simon, Charles F. Reynolds, III, M. Katherine Shear, Natalia Skritskaya and Sidney Zisook21. A Neural Circuit-Based Model for Depression Anchored in a Synthesisof Insights From Functional NeuroimagingAndrea N. Goldstein-Piekarski and Leanne M. Williams22. Could Depression be Preventable? Evidence and PerspectivesScott B. Patten23. Treating Depression in the Era of Precision Medicine: Challenges and PerspectivesMichael Musker and Ma-Li Wong24. Neurobiological Aspects of Functional Recovery in Major Depressive DisorderTrisha Chakrabarty, David Sarfati and Raymond W. Lam25. Diet and Depression: From Epidemiology to Novel TherapeuticsWolfgang Marx, Erin Hoare and Felice Jacka26. Physical Activity and Exercise as a Treatment of Depression: Evidence and Neurobiological MechanismBrendon Stubbs and Felipe Schuch27. Antidepressants and Suicidality—Controversies and Possible MechanismsJosef Witt-Doerring and Sanjay Mathew28. Altered GABAergic Function, Cortical Microcircuitry, and Information Processing in DepressionDwight F. Newton, Corey Fee, Yuliya S. Nikolova and Etienne Sibille29. Biomarker-Based Treatment Selection: A Precision Medicine Approach for DepressionJennifer L. Furman and Madhukar H. Trivedi30. Implications of Pharmacogenomics in Depression Pathophysiology and TreatmentForbes M.P., Jaksa P., Eyre H.A. and Bousman C.31. Novel Neuromodulatory Approaches for Depression: Neurobiological MechanismsLucia Bulubas, Eva Mezger, Daniel Keeser, Frank Padberg and Andre R. Brunoni32. Electroconvulsive Therapy for Depression: Neurobiological MechanismsPeter Mulders, Stevie Jaarsveld, Indira Tendolkar and Philip van Eijndhoven33. Deep Brain Stimulation: Mechanisms Underpinning Antidepressant EffectsSonia Torres-Sanchez, Laura Perez-Caballero and Esther Berrocoso34. Novel Therapeutic Targets for Major Depressive DisorderMax A. Lazar and Roger S. McIntyre35. The Search for Rapid Acting Antidepressants: Research Synthesis and PerspectivesGerard Sanacora, Brandon M. Kitay and Samuel T. Wilkinson36. Pediatric DepressionFrances Rice and Naomi Warne37. Depression in WomenMolly M. Hyer and Gretchen N. Neigh38. Advances in the Neurobiology of Late-Life DepressionBreno Satler Diniz and Antonio Lucio Teixeira