The Exposome

Gary W. Miller, PhD is the Vice Dean for Research Strategy and Innovation and Professor of Environmental Health Sciences at the Mailman School of Public Health at Columbia University. He was founding director of the HERCULES Exposome Research Center at Emory University, the first exposome-based center in the U.S. In addition to his work on the exposome, his research interests include the role of environmental factors in neurodegenerative disorders, such as Parkinson’s disease and Alzheimer’s disease, and the regulation of dopamine signaling in the brain. He served as Editor-in-Chief of Toxicological Sciences, the official journal of the Society of Toxicology, from 2013-2019.

"In chapter 5, Dean Miller provides a comparison of "-omes and citations" from 2013 to 2019. Given the genealogy of the genome (first noted in 1920), the proteome (1994), the transcriptome (1997), epigenomics (1950s), toxigenomics (1999), and the exposome (2005), the latter is certainly the newcomer, making its 10,000-fold citation expansion (2005-2015) astonishing. Exposome-related research and applications are not only relevant to environmental health sciences but factors that will define environmental health sciences and likely public health as well." --Doody

• 1. The Exposome: Purpose, Definitions, and Scope2. Genes, genomes, genomics-advances and limitations3. Nurturing science4. The Environment: The Good, the Bad and the Ugly5. Measuring exposures and their impacts: practical and analytical6. Innovation and the exposome7. Pathways and networks8. Data science and the exposome9. The Exposome in the Community10. The Exposome in the Future