Contemporary Practice in Clinical Chemistry

Dr. William Clarke is a Professor of Pathology at the Johns Hopkins University School of Medicine. His research focuses on the development of analytical methods for drug analysis, clinical mass spectrometry, and devices for point-of-care testing. He serves as the director of Clinical Toxicology for Johns Hopkins Hospital, as well as the Point-of-Care Testing Program for Johns Hopkins Medicine. Dr. Mark Marzinke is Associate Professor of Pathology and Medicine at the Johns Hopkins University School of Medicine.Dr. Marzinke serves as the Director of General Chemistry in the Johns Hopkins Hospital Core Laboratories, and is the Director of the Clinical Pharmacology Analytical Laboratory within the Division of Clinical Pharmacology. He is also Co-Director of the HIV Prevention Trials Network Laboratory Center.

• 1. Preanalytical Variation 2. Statistical Methods in Laboratory Medicine3. Reference Intervals: Theory and Practice4. Method Validation: Finding (and Fixing) the Error of Our Testing Ways5. Quality Control6. Laboratory Calculations7. Spectrophotometry8. Chromatography and Electrophoresis9. Electrochemistry10. Mass Spectrometry11. Nuclear Magnetic Resonance Technology and Clinical Applications12. Immunoassays13. Nucleic Acid Probes Used in the Analysis of DNA14. The Polymerase Chain Reaction15. Laboratory Automation16. Regulatory Issues17. Principles of Laboratory Management18. Evidence-Based Laboratory Medicine19. Harmonization of Results Among Laboratories20. Laboratory Information Systems21. Point-of-Care Testing22. Proteins: Analysis and Interpretation in Serum, Urine, and Cerebrospinal Fluid23. Hemoglobin Variant Detection24. Hemostasis: The View from the Clinical Chemistry Laboratory25. Laboratory Diagnosis of Lipid and Lipoprotein Disorders26. Biomarkers for Acute Cardiovascular Diseases and Heart Failure27. Laboratory Diagnosis of Liver Disease28. Clinical Chemistry of the Gastrointestinal Disorders29. Evaluation of Exocrine Pancreatic Function30. Carbohydrate Disorders31. Laboratory Evaluation of Kidney Function32. Blood Gas and Critical Care Testing33. Water and Electrolyte Balance34. Urinalysis35. Disorders of the Anterior and Posterior Pituitary36. Laboratory Evaluation of Thyroid Function37. Disorders of the Adrenal Cortex and Medulla38. Laboratory Testing in Pregnancy and Reproductive Disorders39. Tumor Markers40. Calcium Biology and Disorders41. Vitamins and Trace Elements: Functions and Assessment of Status through Laboratory Testing 42. Inborn Errors of Metabolism43. The Porphyrias: Fundamentals and Laboratory Assessment44. Pharmacokinetics for the Practicing Clinical Chemist45. Therapeutic Drug Monitoring46. Toxicology and the Clinical Laboratory47. Pharmacogenetics48. Applications of Molecular Techniques in the Clinical Laboratory49. Infectious Disease50. Pediatric Laboratory Medicine51. Diagnostic Body Fluid Testing