Emerging Concepts in Ribosome Structure, Biogenesis, and Function

Dr. Vijay Kumar is currently Professor and J.C. Bose National Fellow in the Department of Molecular and Cellular Medicine at the Institute of Liver and Biliary Sciences (ILBS) in New Delhi, India. He received his PhD in Medical Sciences at All India Institute of Medical Sciences in New Delhi, India and pursued his post-doctoral studies in Molecular Biology at the Université Louis-Pasteur in Strasbourg, France. He has been working in the area of cancer biology for over three decades. His work has focused on signaling mechanisms, cell cycle, DNA replication, ribosomal RNA, and protein synthesis, and he has extensive knowledge of ribosome biogenesis and its involvement in cell transformation and cancerous growth. He has done pioneering work in the area of steroid hormone receptors, regulation of RNA polymerase I-dependent transcription and ribosome biogenesis, cell cycle regulation, hepatitis B virus and hepatocellular carcinoma, and hepatoprotective mechanisms of medicinal plants. His current research interest includes the role of microRNA in health and disease. Dr. Kumar is a recipient of several national awards and is a fellow of National Academy of Sciences, National Academy of Medical Sciences, and the National Academy of Agricultural Sciences of India.

• 1. Introduction to ribosome factory, origin and evolution of translation2. Ribosome structure3. rDNA gene structure, transcription and their co-regulation4. Ribosomal proteins - their balanced production5. Ribosome diversity6. Ribosome cycle - Assembly, degradation, and recycling7. Ribosomal biogenesis in eukaryotes8. Protein biogenesis in prokaryotes9. Translation - Process and control10. Inhibitores of ribosome biogenesis in prokaryotes and eukaryotes11. Ribosomopathies - A tree of pathologies with many roots and branches!12. Ribosomal profiling - Diversity and applications