Carbonic Anhydrases

Dr. Claudiu T. Supuran received his BSc in chemistry from the Polytechnic University of Bucharest, Romania (1987) and PhD in chemistry at the same university in 1991. In 1990, he became Assistant and then Associate Professor of Chemistry at the University of Bucharest. He was Visiting Scholar at the University of Florida, Gainesville, United States, at Griffith University, Brisbane, Australia, and Visiting Professor at University of La Plata, Argentina. In 1995 he moved to the University of Florence, Italy, where he is currently Full Professor in the Department of Neuroscience, Psychology, Medicine and Child Health. His main research interests include design of enzyme inhibitors and activators, heterocyclic chemistry, chemistry of sulfonamides, sulfamates, and sulfamides, biologically active organo-element derivatives, QSAR studies, X-ray crystallography of metallo-enzymes, metal complexes with biologically active ligands (metal-based drugs), carbonic anhydrases, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives among others. He has published more than 1900 papers in these fields. Dr. Alessio Nocentini currently works at the Department of Neuroscience, University of Florence, Italy. He recently concluded his PhD thesis, which dealt with several aspects of carbonic anhydrase, spanning from drug-design, synthesis of inhibitors, and molecular modeling to biological evaluations of carbonic anhydrase modulators. He is now a post-doctoral researcher in Professor Supuran’s research team.

• 1. Carbonic Anhydrases: An Overview2. α-Carbonic Anhydrases3. β-Carbonic Anhydrases4. γ-Carbonic Anhydrases5. δ-Carbonic Anhydrases6. ζ-Carbonic Anhydrases7. η and θ-Carbonic Anhydrases8. Human Carbonic Anhydrases: Tissue Distribution, Physiological Role and Druggability9. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Zinc Binders10. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds That Anchor to The Zinc-Bound Nucleophile11. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds Occluding the Entrance of The Active Site12. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds That Bind “Out of The Binding Site” And Compounds with An Unknown Mechanism of Action13. Carbonic Anhydrase Inhibitors as Ophthalmologic Drugs for The Treatment of Glaucoma14. Carbonic Anhydrase Inhibitors as Diuretics15. Carbonic Anhydrase Inhibitors for The Treatment of Epilepsy and Obesity16. Carbonic Anhydrase Inhibitors for The Treatment of Tumors: Therapeutic, Immunologic, And Diagnostic Tools Targeting Isoforms IX And XII17. Carbonic Anhydrase Inhibitors for The Treatment of Neuropathic Pain and Arthritis18. Carbonic Anhydrases from Pathogens: Bacterial Cas And Their Inhibitors as Potential Anti-Infectives 19. Carbonic Anhydrases from Pathogens: Fungal Cas And Their Inhibitors as Potential Antifungal Agents20. Carbonic Anhydrases from Pathogens: Protozoan Cas And Related Inhibitors as Potential Anti-Protozoal Agents21. Carbonic Anhydrase Activators and Their Potential in The Pharmaceutical Field22. Biotechnological Applications of Carbonic Anhydrases from Extremophiles23. CO2 Capture by Engineered Mammalian Carbonic Anhydrases