Nutritional Epigenomics

Bradley S. Ferguson is an Associate Professor of Nutrition at the University of Nevada, Reno, Nevada. His lab adopts integrative, translational research approaches that encompass bioinformatics, in vitro cell culture, and in vivo animal models to elucidate dietary food components that act as epigenetic modifiers, as well as the role of dietary epigenetic modifiers on pathological cardiac signaling, gene expression, and remodeling. He also seeks to understand how sarcomere protein acetylation links metabolic disease (obesity and diabetes) to pathological cardiac remodeling and skeletal muscle dysfunction. Dr. Ferguson has published his findings across a wide range of peer-reviewed journals, including Scientific Reports, Journal of Animal Science, American Journal of Physiology, Cell Reports, PNAS, and the Journal of Molecular and Cellular Cardiology.

• SECTION I Introduction1. Introduction to nutritional epigenomicsSECTION II Epigenetic regulators2. DNA methylation and chromatin modifications3. Small non-coding RNAs as epigenetic regulatorsSECTION III Epigenomic regulation of disease4. The impact of race and ethnicity in the social epigenomic regulation of disease5. The epigenomic impact of methylation in metabolic dysfunction and cancer6. The role for DNA/RNA methylation on neurocognitive dysfunctions7. Histone acylation in the epigenomic regulation of insulin action and metabolic disease8. Cancer and non-coding RNAs9. Race in the social-epigenomic regulation of pre- and perinatal development10. Maternal nutrition, epigenetic programming and metabolic syndrome11. Epigenetic inheritance of metabolic signals12. The paternal diet regulates the offspring epigenome and healthSECTION V Nutritional epigenomics and the circadian clock13. The interplay between diet, epigenetics and the circadian clock14. Epigenetic regulation of the fetal circadian clock: implications for nutritional programming of circadian and metabolic function15. The role for the microbiome in the regulation of the circadian clock and metabolismSECTION VI Carloric restriction and exercise in the epigenomic regulation of aging and disease16. Epigenomic reprogramming of caloric restriction on aging17. Dietary restriction in the epigenomic regulation of cardiovascular diseases18. Epigenomic adaptations of exercise in the control of metabolic disease and cancerSECTION VII Macro- and micronutrients as epigenomic regulators of health and disease19. B-vitamins and one-carbon metabolism: impacts on the epigenome during development20. Food bioactives in the epigenomic regulation of metabolic disease21. Stilbenoids as dietary regulators of the cancer epigenome22. Regulation of non-coding RNAs by phytochemicals for cancer therapy23. Short chain fatty acids as epigenetic and metabolic regulators of neurocognitive health and diseaseSECTION VIII Diet, epigenetics and the microbiome24. Diet-microbiome interactions and the regulation of the epigenome25. Gut dysbiosis and its epigenomic impact on disease26. Microbiota, the brain and epigenetics