Häftad, Engelska, 2020

RNA-Based Regulation in Human Health and Disease

2022 kr

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Beskrivning

RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics.

Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease
Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies
Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic
Features contributions from leading experts in the field

Produktinformation

Utgivningsdatum: 2020-08-19
Mått: 191 x 235 x 26 mm
Vikt: 910 g
Format: Häftad
Språk: Engelska
Serie: Translational Epigenetics
Antal sidor: 444
Förlag: Elsevier Science
Medarbetare: Rajesh Pandey
ISBN: 9780128171936

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Mer om författaren

In earning his PhD, Dr. Rajesh Pandey used a combination of functional genomics and computational tools to elucidate the role of noncoding RNA during stress response. This convinced him of the potential of the RNA regulatory repertoire and its role in shaping human evolution, health, disease states, diagnosis, prognosis, and therapeutics. Subsequently, he has employed diverse genomic toolkits to understand and explore RNA-level regulation at different hierarchies, encompassing human, mouse, plant, fungi, bacteria genomics, and metagenomics. In addition to his research work, Dr. Pandey has been a tutor at many workshops on applications of NGS technologies, and has published peer reviewed papers in such journals as Genome Biology; Genome Biology and Evolution; Nucleic Acids Research; Journal of Cell Science; PLOS Genetics; Frontiers in Microbiology; Scientific Reports; Molecular Cell; and Clinical Genetics. His future interest lies in investigating the role of noncoding RNA in modulating human phenotypic variation and its impact on health and disease spectrum.

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