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    1. Naturvetenskap och teknik
    2. Matematik och naturvetenskap
    3. Biologi
    4. Biovetenskap

    Epigenetics and Reproductive Health

    Häftad, Engelska, 2020

    Del 21 i serien Translational Epigenetics

    1 714 kr

    Beställningsvara. Skickas inom 10-15 vardagar. Fri frakt över 249 kr.

    Beskrivning

    Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted reproductive technologies. Emphasis is placed on identifying biomarkers for early detection of aberrant epigenetic mechanisms.

    Later chapters examine the possibility of correcting these epigenetic dysfunctions, as well as current challenges and next steps in research, enabling new translational discoveries and efforts towards developing therapeutics.



    • Thoroughly examines the influence of aberrant epigenetics during gametogenesis and embryogenesis, affecting parents, gametes and embryos, offspring and future generations
    • Explores health outcomes for reproductive senescence, endocrine disruption, testicular cancer, prostrate cancer, breast cancer, ovarian, cancer, endometrial cancer and cervical cancers
    • Features chapter contributions from international researchers in the field

    Produktinformation

    • Utgivningsdatum:2020-09-18
    • Mått:191 x 235 x undefined mm
    • Vikt:860 g
    • Format:Häftad
    • Språk:Engelska
    • Serie:Translational Epigenetics
    • Antal sidor:444
    • Förlag:Elsevier Science
    • ISBN:9780128197530

    Utforska kategorier

    • Biovetenskap inom Naturvetenskap och teknik

    Mer om författaren

    Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources. Dr. Nafisa Balisinor received her B.Sc. and M.Sc. at the Sophia College University of Mumbai, and her Ph.D. at the Institute for Research in Reproduction, University of Bombay (Biochemistry, 1989). She has published widely on topics in reproductive neuroendocrinology and epigenetics, in such peer reviewed journals as the International Journal of Biological Macromolecules, Epigenetics, Endocrinology, Andrologia, and the Journal of Steroid Biochemistry and Molecular Biology. Currently Dr. Nafisa Balasinor is a Scientist and Head of the Department of Neuroendocrinology, at the National Institute for Research in Reproductive Health India, Mumbai, India. Dr. Priyanka Parte received her first M.Sc. at the University of Mumbai (Applied Biology, 1992), and her second M.Sc at the University of Edinburgh , Scotland , U.K. (Reproductive Biology; 1996). She received her Ph.D. at the University of Mumbai, (Biochemistry, 2000), followed by a Post-Doctoral fellowship at the University of Massachusetts, Worcester (Biochemistry & Mol. Pharmacology.; 2003-2004). Currently, she is a Scientist and Head of the Department of Gamete Immunobiology at the National Institute for Research in Reproductive Health India, Mumbai, India. She has published articles in such peer reviewed journals as Fertility and Sterility, Cell and Tissue Research, Molecular Reproduction and Development, and the Journal of Proteomics. Dr. Dipty Singh received her Ph.D at the University of Mumbai (Life Sciences, 2010), and her M.Sc at the University of Allahabad (Biotechnology, 2004). Her research interests include reproductive biology, endocrine disruptors, and bacterial cell division proteins and their small molecule inhibitors. In her previous role she was a Research Associate at the Department of Biosciences & Bioengineering, IIT Mumbai, and is now a Scientist at the National Institute for Research in Reproductive Health India, Mumbai, India. She has published a range of peer journals, including Biochemistry, Chemosphere, the Journal of Pharmacopuncture, and the Journal of Nanobiotechnology.

    Recensioner i media

    "I believe this to be the first of many textbooks on this topic. It is a much-needed summary of important advancements in the field of epigenetics and reproductive health. It is a very detailed review intended for expects in the field and those devoted to continued research in this area." --Doody

    Innehållsförteckning

    • SECTION I Spermatogenesis, oogenesis and fertility1. Epigenome reprogramming in the male and female germ line2. Genomic imprinting3. Chromatin remodeling of the male genome during spermiogenesis and embryo development4. Epigenetic regulation in stem cells5. Aberrant epigenetics and reproductive disordersSECTION II Pregnancy/developmental/placental epigenetics6. Epigenetic reprogramming in the embryo7. Epigenetic regulation during placentation8. Epigenetic modulation during pregnancy and pregnancy related disorders9. Epigenetic involvement in fetal and neonatal origins of late-onset diseaseSECTION III Epigenetic – lifestyle, aging and environmental influence10. Impact of environmental chemicals and endocrine disruptors on mammalian germ cell epigenome11. Influence of nutrition on reproductive health through epigenetic mechanisms12. Influence of stress and lifestyle on epigenetic modifications13. Aging of male and female gametesSECTION IV Reproductive cancer and epigenetics14. Testicular and prostate cancers15. Emerging patterns and implications of breast cancer epigenetics: An update of the current knowledge16. Ovarian and endometrial cancers17. Epigenetic aberrations in cervical cancerSECTION V Epigenetics in diagnosis, prognosis and therapy18. Natural molecules as epigenetic modifiers in reproduction