Prions and Neurodegenerative Diseases

Giuseppe Legname carried undergraduate and postgraduate studies in biochemistry and molecular biology at the Università degli Studi of Milan, Italy. He gained his Doctor of Philosophy (D.Phil.) degree in Biological Sciences at the University of Warwick in 1997. After a long spell in Industry where he coauthored many scientific papers and patents in the field of immunotherapy, he moved to academia at the National Institute for Medical Research (NIMR), Medical Research Council in London, UK.In 1999 he joined the faculty of the Department of Neurology at the University of California at San Francisco (UCSF), California, USA.During the seven-and-half years at UCSF he was involved in basic research projects in the field of Prion Biology and Disease at the Institute for Neurodegenerative Diseases (IND), under the direction of 1997 Nobel Laureate Professor Stanley B. Prusiner.Since December 2006, he has joined the faculty of the Scuola Internazionale Superiore di Studi Avanzati (SISSA), in Trieste, where he is currently managing a new Prion Biology Laboratory.At IND he was responsible for several Projects and Science Cores of funded National Health Institute (NIH) grants on prions. During his scientific experience in the USA he has coauthored several seminal papers, book chapters and patents. At SISSA, Giuseppe Legname has joined the Neuroscience Department and the main focus of his research program is in the field of mammalian Prion Biology (physiological function of the prion protein in mammals) and Prion Disease (mechanisms of prion replication and structural characterization of molecular determinants for prion infectivity).

• Chapters to include:Cell-free amplification of prions: where do we stand?Fabio ModaTransgenic mouse models for the study of prion diseasesJuan Maria Torres