Lahita's Systemic Lupus Erythematosus

Inbunden, Engelska, 2021

2 981 kr

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Beskrivning

Lahita's Systemic Lupus Erythematosus, Seventh Edition is a current, authoritative reference on systemic lupus erythematosus (SLE), one of the most heterogeneous and mechanistically complex of autoimmune diseases. The field has undergone rapid transformation since the previous edition, with regulatory approval of targeted biologics, clarification of molecular mechanisms driving immune dysregulation, and the emergence of precision medicine approaches to patient stratification. This volume addresses the demand for a comprehensive, integrated resource reflecting these advances for specialists in SLE research and clinical care.

The reference spans the full breadth of SLE biology and clinical management. Content covers the genetic and epigenetic determinants of susceptibility, B and T cell dysregulation, innate immune mechanisms including interferon signaling and neutrophil biology, complement activation, microbiome contributions, and metabolic dysfunction in immune cells. Clinical content addresses the presentation and management of SLE across organ systems-including renal, neuropsychiatric, cardiovascular, pulmonary, cutaneous, musculoskeletal, and hematologic manifestations-alongside antiphospholipid syndrome and malignancy surveillance. Therapeutic chapters span antimalarials and glucocorticoids through approved targeted biologics and investigational CAR-T cell approaches, with attention to pregnancy management, global health disparities, and precision treatment strategies.

Lahita's Systemic Lupus Erythematosus equips rheumatologists, clinical immunologists, and multidisciplinary specialists with the scientific foundation and clinical guidance required for contemporary SLE practice. Contributions from international experts spanning five continents provide a global perspective on disease heterogeneity and outcomes. Integrated coverage of AI-assisted monitoring, molecular biomarkers, and precision stratification frameworks positions this reference as essential reading for clinicians and translational researchers in autoimmunity.

. Synthesizes advances in SLE pathogenesis, from genetics and epigenetics to innate and adaptive immunopathogenesis
. Covers approved and investigational therapies including type I interferon blockade and CAR-T cell approaches
. Addresses precision medicine frameworks incorporating AI-driven monitoring and molecular patient stratification
. Provides international perspectives on SLE epidemiology, health disparities, and outcomes

Produktinformation

Utgivningsdatum:2021-07-27
Mått:216 x 276 x undefined mm
Vikt:2 200 g
Format:Inbunden
Språk:Engelska
Antal sidor:730
Upplaga:6
Förlag:Elsevier Science
ISBN:9780128205839

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Mer om författaren

Robert G. Lahita, MD, PhD, is Clinical Professor of Medicine at Hackensack Meridian School of Medicine and Director of the Institute for Autoimmune and Rheumatic Diseases at St. Joseph's Health, Wayne, New Jersey. A Fellow of the American College of Physicians and the Royal College of Physicians, and a Master of the American College of Rheumatology, he serves as Associate Editor of Lupus: An International Journal. His research focuses on the immunopathogenesis of systemic lupus erythematosus, immune endocrinology, and the hormonal regulation of autoimmunity. He has served as editor of Systemic Lupus Erythematosus across multiple editions and as Senior Editor of the Textbook of Autoimmune Diseases.

Recensioner i media

"This sixth edition offers up-to-date information pertaining to various aspects of systemic lupus erythematosus (SLE).... The book focuses on updating rheumatology specialists with recent discoveries in genetics, immunology, microbiology, and microbiome, and expands on how these discoveries pertain to the pathogenesis of SLE.... The second part focuses on clinical SLE and later explores the potential of new treatments based on these findings. This book is definitely needed given the significant findings that help to explain SLE. The chapters are well written and meet the objectives of updating specialists about SLE. This book is targeted to specialists in rheumatology given the complexity and detail of each chapter.... Each chapter is well written and supported by up-to-date references.... Diagrams are well visualized and interpreted for readers. Overall, this is an excellent book and very much needed given the recent discoveries. This book is a must-read for rheumatologists." --Joseph S Yusin, MD(VA Greater Los Angeles Healthcare System)

Innehållsförteckning

Part I: Basis of the DiseaseSection A: Genetics and epigenetics1. Major histocompatibility complex and SLE2. Lupus Susceptibility genes3. Epigenetics in systemic lupus erythematosus and the integration of molecular pathwaysSection B: Immunopathogenesis4. Autoantigens, antigenic mimicry, and immune complexes5. B-cell Biology, tolerance and autoantibodies6. T-Cell Biology, tolerance and regulation7. Polymorphonuclear cells8. Metabolic and mitochondrial dysfunction in SLE9. Immunopathogenesis: the role of mucosal and skin microbiota in SLESection C: Disease effectors and modifiers10. Complement and SLE11. Interferons and cytokines in SLE pathogenesis and therapy12. Innate immunity in SLE pathogenesis13. Sex bias in SLESection D: Tissue injury—the Biology14. Mechanisms of tissue injury in lupus nephritis15. The skin16. The brain in SLE: mechanisms and detection of injury and therapeutic strategies17. The role of infections in SLE pathogenesis18. Tissue injurydthe biology: SLE-associated vascular disease and antiphospholipid syndromePart II: Clinical presentation of diseaseSection A: Clinical presentation19. Epidemiology of SLE and related diseases: incidence, prevalence, and mortality20. The clinical presentation of systemic lupus erythematosus and laboratory diagnosis21. Passively acquired lupus in the fetus and neonate22. Systemic lupus erythematosus in children23. Environmental and drug-induced lupus24. Reproductive health25. Monitoring disease activity26. Overlap syndromesSection B: Specific organ involvement and clinical presentation27. Nervous system28. Skin29. Kidney disease30. Cardiovascular disease in lupus31. Pulmonary manifestations of systemic lupus erythematosus32. GI hepatic and nonhepatic diseases33. Musculoskeletal system: articular disease, myositis, and bone metabolism34. Clinical presentation of antiphospholipid syndrome35. Hematology: cytopenias36. Malignancy risk and screeningSection C: Treatment of systemic llupus erythematosus37. Antimalarial drugs (and lupus)38. Glucocorticoids39. Immunosuppressive therapy in SLE40. Pipeline therapies and future drug development41. Challenges of systemic lupus clinical trials

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