Robert Lahita – författare

Systemic Lupus Erythematosus, Fourth Edition, provides an understanding of the basic mechanisms as well as the diagnostic and therapeutic aspects of lupus. This book is attractive to both the investigative community and clinicians. As lupus has become a paradigm for the study of autoimmune disease, immunologists investigating autoimmunity are becoming more interested in lupus. Basic immunology of phospholipid antibodies, clotting abnormailities, issues concerning pathogenetic fit with SLE, and newest methods of therapy of APLS are given in this newest edition of a classic reference.- Comprehensive current coverage of basic models of etiology and pathogenesis- Complete catalog of autoantibodies produced- Includes an outstanding review of imaging techniques for the diagnosis of lupus and its complications for each organ system- Includes CD-ROM of images excellent for teaching purposes and downloading into presentations

Systemic lupus erythematosus (S.L.E.), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body''s immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission.Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness.To date, lupus has no known cause or cure. Early detection and treatment is the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, anti-malarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, similar to those used in the treatment of cancer, are also used to suppress the immune system in lupus patients.A new edition of this established and well regarded reference which combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.- Highly illustrated and in full color throughout- Basic science section expanded to allow the reader to focus on the newest techniques in molecular medicine and its effects on disease expression and treatment- Clinical aspects and new drugs will be covered in great detail providing a useful reference to both experienced clinicians and physicians with an interest in lupus in their clinical practice

Systemic lupus erythematosus (S.L.E.), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission.

Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness.

To date, lupus has no known cause or cure. Early detection and treatment is the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, anti-malarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, similar to those used in the treatment of cancer, are also used to suppress the immune system in lupus patients.

A new edition of this established and well regarded reference which combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.

Highly illustrated and in full color throughout Basic science section expanded to allow the reader to focus on the newest techniques in molecular medicine and its effects on disease expression and treatment Clinical aspects and new drugs will be covered in great detail providing a useful reference to both experienced clinicians and physicians with an interest in lupus in their clinical practice

Lahita's Systemic Lupus Erythematosus, Seventh Edition is a current, authoritative reference on systemic lupus erythematosus (SLE), one of the most heterogeneous and mechanistically complex of autoimmune diseases. The field has undergone rapid transformation since the previous edition, with regulatory approval of targeted biologics, clarification of molecular mechanisms driving immune dysregulation, and the emergence of precision medicine approaches to patient stratification. This volume addresses the demand for a comprehensive, integrated resource reflecting these advances for specialists in SLE research and clinical care.The reference spans the full breadth of SLE biology and clinical management. Content covers the genetic and epigenetic determinants of susceptibility, B and T cell dysregulation, innate immune mechanisms including interferon signaling and neutrophil biology, complement activation, microbiome contributions, and metabolic dysfunction in immune cells. Clinical content addresses the presentation and management of SLE across organ systems-including renal, neuropsychiatric, cardiovascular, pulmonary, cutaneous, musculoskeletal, and hematologic manifestations-alongside antiphospholipid syndrome and malignancy surveillance. Therapeutic chapters span antimalarials and glucocorticoids through approved targeted biologics and investigational CAR-T cell approaches, with attention to pregnancy management, global health disparities, and precision treatment strategies.Lahita's Systemic Lupus Erythematosus equips rheumatologists, clinical immunologists, and multidisciplinary specialists with the scientific foundation and clinical guidance required for contemporary SLE practice. Contributions from international experts spanning five continents provide a global perspective on disease heterogeneity and outcomes. Integrated coverage of AI-assisted monitoring, molecular biomarkers, and precision stratification frameworks positions this reference as essential reading for clinicians and translational researchers in autoimmunity.. Synthesizes advances in SLE pathogenesis, from genetics and epigenetics to innate and adaptive immunopathogenesis. Covers approved and investigational therapies including type I interferon blockade and CAR-T cell approaches. Addresses precision medicine frameworks incorporating AI-driven monitoring and molecular patient stratification. Provides international perspectives on SLE epidemiology, health disparities, and outcomes