Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience. Aitziber Buqué (born 1980) is currently Post-Doctoral Fellow in the laboratory of Dr. Lorenzo Galluzzi with the Department of Radiation Oncology of the Weill Cornell Medical College (New York, NY, USA). Prior to joining the Galluzzi lab (2018), Aitziber Buqué was a Post-Doctoral Fellow in the Research Team “Apoptosis, Cancer and Immunity” at the Cordeliers Research Center (Paris, France; 2014-2018), under the direction of Dr. Guido Kroemer, after receiving her PhD from the University of the Basque Country (Leioa, Spain; 2013). Aitziber Buqué is interested in the molecular, cellular and immunological mechanisms whereby breast cancer evades immunosurveillance and resists to immunotherapy, and she is the author of more than 30 scientific articles in international peer-reviewed journals.

• Preface - Autophagy: An old mechanism with new challenges aheadAitziber Buqué and Lorenzo Galluzzi1. Nucleophagy mediators and mechanismsMargarita-Elena Papandreou and Nektarios Tavernarakis2. Scaffold proteins in bulk and selective autophagyChristopher Eickhorst, Mariya Licheva and Claudine Kraft3. A global view of the miRNA-mitophagy connexionFlavie Strappazzon4. Crosstalk between autophagy and apoptosis: Mechanisms and therapeutic implicationsAndrew Thorburn5. Autophagy in immunityChristian Münz6. Autophagy in cardiovascular health and disease  Mahmoud Abdellatif, Senka Ljubojevic-Holzer, Frank Madeo and Simon Sedej7. Autophagy in kidney disease: Advances and therapeutic potentialDivya Bhatia and Mary E. Choi8. Autophagy in chronic lung diseaseAlexandra C. Racanelli, Augustine M.K. Choi and Mary E. Choi9. Autophagy contribution to motor neuron disease pathologyNatalia Rodríguez-Muela10. Strategies employed by viruses to manipulate autophagyNilima Dinesh Kumar, Jolanda M. Smit and Fulvio Reggiori11. Crinophagy mechanisms and its potential role in human health and diseaseTamás Csizmadia and Gábor Juhász12. Autophagy role in environmental pollutants exposureGemma G. Martínez-García and Guillermo Mariño13. Genetic defects of autophagy linked to diseaseMilana Fraiberg and Zvulun Elazar14. C. elegans to model autophagy-related human disordersShi Q. Wong, Anita V. Kumar, Joslyn Mills and Louis R. Lapierre15. Drosophila as a model to understand autophagy deregulation in human disordersDonna Denton, Louise O'Keefe and Sharad Kumar

Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience. Aitziber Buqué (born 1980) is currently Post-Doctoral Fellow in the laboratory of Dr. Lorenzo Galluzzi with the Department of Radiation Oncology of the Weill Cornell Medical College (New York, NY, USA). Prior to joining the Galluzzi lab (2018), Aitziber Buqué was a Post-Doctoral Fellow in the Research Team “Apoptosis, Cancer and Immunity” at the Cordeliers Research Center (Paris, France; 2014-2018), under the direction of Dr. Guido Kroemer, after receiving her PhD from the University of the Basque Country (Leioa, Spain; 2013). Aitziber Buqué is interested in the molecular, cellular and immunological mechanisms whereby breast cancer evades immunosurveillance and resists to immunotherapy, and she is the author of more than 30 scientific articles in international peer-reviewed journals.

• Preface - Autophagy: An old mechanism with new challenges aheadAitziber Buqué and Lorenzo Galluzzi1. Nucleophagy mediators and mechanismsMargarita-Elena Papandreou and Nektarios Tavernarakis2. Scaffold proteins in bulk and selective autophagyChristopher Eickhorst, Mariya Licheva and Claudine Kraft3. A global view of the miRNA-mitophagy connexionFlavie Strappazzon4. Crosstalk between autophagy and apoptosis: Mechanisms and therapeutic implicationsAndrew Thorburn5. Autophagy in immunityChristian Münz6. Autophagy in cardiovascular health and disease  Mahmoud Abdellatif, Senka Ljubojevic-Holzer, Frank Madeo and Simon Sedej7. Autophagy in kidney disease: Advances and therapeutic potentialDivya Bhatia and Mary E. Choi8. Autophagy in chronic lung diseaseAlexandra C. Racanelli, Augustine M.K. Choi and Mary E. Choi9. Autophagy contribution to motor neuron disease pathologyNatalia Rodríguez-Muela10. Strategies employed by viruses to manipulate autophagyNilima Dinesh Kumar, Jolanda M. Smit and Fulvio Reggiori11. Crinophagy mechanisms and its potential role in human health and diseaseTamás Csizmadia and Gábor Juhász12. Autophagy role in environmental pollutants exposureGemma G. Martínez-García and Guillermo Mariño13. Genetic defects of autophagy linked to diseaseMilana Fraiberg and Zvulun Elazar14. C. elegans to model autophagy-related human disordersShi Q. Wong, Anita V. Kumar, Joslyn Mills and Louis R. Lapierre15. Drosophila as a model to understand autophagy deregulation in human disordersDonna Denton, Louise O'Keefe and Sharad Kumar