Metalloenzymes

Dr. Claudiu T. Supuran received his BSc in chemistry from the Polytechnic University of Bucharest, Romania (1987) and PhD in chemistry at the same university in 1991. In 1990, he became Assistant and then Associate Professor of Chemistry at the University of Bucharest. He was Visiting Scholar at the University of Florida, Gainesville, United States, at Griffith University, Brisbane, Australia, and Visiting Professor at University of La Plata, Argentina. In 1995 he moved to the University of Florence, Italy, where he is currently Full Professor in the Department of Neuroscience, Psychology, Medicine and Child Health. His main research interests include design of enzyme inhibitors and activators, heterocyclic chemistry, chemistry of sulfonamides, sulfamates, and sulfamides, biologically active organo-element derivatives, QSAR studies, X-ray crystallography of metallo-enzymes, metal complexes with biologically active ligands (metal-based drugs), carbonic anhydrases, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives among others. He has published more than 1900 papers in these fields. Dr. William Alexander Donald is an academic and research group leader in the School of Chemistry at the University of New South Wales, Australia. His research interests include carbonic anhydrases, coordination chemistry, and the development of bioanalytical methodologies for improving drug discovery and development. He has published more than 120 papers in these fields.

• 1. Introduction to metalloenzymesSection II2. Magnesium and calcium-containing enzymesSection III3. Zinc enzymesSection IV. Other metalloenzymes4. Manganese enzymes5. Nickel enzymes6. Iron enzymes (heme-containing)7. Iron enzymes (non-heme containing, Fe(II) or Fe(III) proteins)8. Copper enzymes9. Cadmium enzymes10. Molybdenum enzymes11. Tungsten-containing enzymes